The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Collagenase (Catalytic Domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: A disintegrin and metalloproteinase with thrombosp...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
ADAMTS-4 endopeptidase. [EC: 3.4.24.82]
Glutamyl endopeptidase. Bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala- Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan.
  • Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix.
  • Belongs to peptidase family M12.
8 A0A0B4J1L2 A0A0B4J1L2 O75173 Q5RFQ8 Q8BNJ2 Q8BNJ2 Q9ESP7 Q9TT93
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