The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Mitochondrial aldehyde dehydrogenase 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 41 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
30 P00352 (/IDA) P00352 (/IDA) P00352 (/IDA) P05091 (/IDA) P05091 (/IDA) P05091 (/IDA) P11884 (/IDA) P13601 (/IDA) P40047 (/IDA) P40047 (/IDA)
(20 more)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
23 A0A0B4K6I6 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) P15437 (/ISS) P24549 (/ISS)
(13 more)
Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030
Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
19 P40047 (/IDA) P40047 (/IDA) P40047 (/IDA) P40047 (/IDA) P40047 (/IDA) P40047 (/IDA) P40047 (/IDA) P40047 (/IDA) P46367 (/IDA) P46367 (/IDA)
(9 more)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
19 P00352 (/ISS) P00352 (/ISS) P00352 (/ISS) P05091 (/ISS) P05091 (/ISS) P05091 (/ISS) P12762 (/ISS) P13601 (/ISS) P15437 (/ISS) P20000 (/ISS)
(9 more)
Retinal dehydrogenase activity GO:0001758
Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.
17 O93344 (/ISS) O93344 (/ISS) O94788 (/ISS) P00352 (/ISS) P00352 (/ISS) P00352 (/ISS) P15437 (/ISS) P24549 (/ISS) P27463 (/ISS) P51977 (/ISS)
(7 more)
Retinal dehydrogenase activity GO:0001758
Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.
9 O94788 (/IDA) P47895 (/IDA) P47895 (/IDA) P48644 (/IDA) P51647 (/IDA) Q28399 (/IDA) Q62148 (/IDA) Q63639 (/IDA) Q8HYE4 (/IDA)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
8 P08157 (/IMP) P11884 (/IMP) P46367 (/IMP) P46367 (/IMP) P46367 (/IMP) P46367 (/IMP) P46367 (/IMP) P46367 (/IMP)
3-chloroallyl aldehyde dehydrogenase activity GO:0004028
Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
6 A2BGR9 (/IDA) P13601 (/IDA) P24549 (/IDA) Q62148 (/IDA) Q7SXU3 (/IDA) Q8QGQ2 (/IDA)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
6 P00352 (/TAS) P00352 (/TAS) P00352 (/TAS) P05091 (/TAS) P05091 (/TAS) P05091 (/TAS)
Retinal dehydrogenase activity GO:0001758
Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.
4 P24549 (/ISO) Q62148 (/ISO) Q9JHW9 (/ISO) Q9JHW9 (/ISO)
Showing 1 to 10 of 41 entries

There are 171 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
9 P00352 (/ISS) P00352 (/ISS) P00352 (/ISS) P15437 (/ISS) P27463 (/ISS) P51977 (/ISS) P86886 (/ISS) P86886 (/ISS) Q8MI17 (/ISS)
Acetate biosynthetic process GO:0019413
The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.
9 P08157 (/IMP) P40047 (/IMP) P40047 (/IMP) P40047 (/IMP) P40047 (/IMP) P40047 (/IMP) P40047 (/IMP) P40047 (/IMP) P40047 (/IMP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
8 O93344 (/ISS) O93344 (/ISS) Q62148 (/ISS) Q63639 (/ISS) Q8K4D8 (/ISS) Q9I8W8 (/ISS) Q9JHW9 (/ISS) Q9JHW9 (/ISS)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
8 P00352 (/IDA) P00352 (/IDA) P00352 (/IDA) P48644 (/IDA) P51647 (/IDA) P51977 (/IDA) Q8HYE4 (/IDA) Q8MI17 (/IDA)
Ethanol metabolic process GO:0006067
The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
7 P08157 (/IMP) P46367 (/IMP) P46367 (/IMP) P46367 (/IMP) P46367 (/IMP) P46367 (/IMP) P46367 (/IMP)
Ethanol oxidation GO:0006069
An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate.
7 P00352 (/TAS) P00352 (/TAS) P00352 (/TAS) P05091 (/TAS) P05091 (/TAS) P05091 (/TAS) P30837 (/TAS)
Fermentation GO:0006113
The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP).
7 A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
6 P46367 (/IMP) P46367 (/IMP) P46367 (/IMP) P46367 (/IMP) P46367 (/IMP) P46367 (/IMP)
NADPH regeneration GO:0006740
A metabolic process that generates a pool of NADPH by the reduction of NADP+.
6 P46367 (/IGI) P46367 (/IGI) P46367 (/IGI) P46367 (/IGI) P46367 (/IGI) P46367 (/IGI)
Acetate biosynthetic process GO:0019413
The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.
6 P46367 (/IGI) P46367 (/IGI) P46367 (/IGI) P46367 (/IGI) P46367 (/IGI) P46367 (/IGI)
Showing 1 to 10 of 171 entries

There are 31 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
18 P40047 (/HDA) P40047 (/HDA) P40047 (/HDA) P40047 (/HDA) P40047 (/HDA) P40047 (/HDA) P40047 (/HDA) P40047 (/HDA) P46367 (/HDA) P46367 (/HDA)
(8 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
14 A0A024RC95 (/IDA) A0A024RC95 (/IDA) H0Y2X5 (/IDA) P00352 (/IDA) P00352 (/IDA) P00352 (/IDA) P47895 (/IDA) P47895 (/IDA) P48644 (/IDA) Q63639 (/IDA)
(4 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 P00352 (/ISS) P00352 (/ISS) P00352 (/ISS) P15437 (/ISS) P24549 (/ISS) P27463 (/ISS) P51647 (/ISS) P51977 (/ISS) P86886 (/ISS) P86886 (/ISS)
(1 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 P11884 (/IDA) P30837 (/IDA) P46367 (/IDA) P46367 (/IDA) P46367 (/IDA) P46367 (/IDA) P46367 (/IDA) P46367 (/IDA) Q9SU63 (/IDA) Q9VLC5 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
8 P00352 (/HDA) P00352 (/HDA) P00352 (/HDA) P05091 (/HDA) P05091 (/HDA) P05091 (/HDA) P47895 (/HDA) P47895 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 O94788 (/IDA) P47895 (/IDA) P47895 (/IDA) P51647 (/IDA) Q9JHW9 (/IDA) Q9JHW9 (/IDA) Q9VLC5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 A0A024RC95 (/IDA) A0A024RC95 (/IDA) H0Y2X5 (/IDA) P47895 (/IDA) P47895 (/IDA) P51647 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 O94788 (/TAS) P00352 (/TAS) P00352 (/TAS) P00352 (/TAS) P47895 (/TAS) P47895 (/TAS)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
6 P46367 (/IDA) P46367 (/IDA) P46367 (/IDA) P46367 (/IDA) P46367 (/IDA) P46367 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 A0A024RC95 (/IDA) A0A024RC95 (/IDA) H0Y2X5 (/IDA) P47895 (/IDA) P47895 (/IDA)
Showing 1 to 10 of 31 entries
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