The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 129: Chloride intracellular channel protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
5 O00299 (/IDA) O00299 (/IDA) O00299 (/IDA) O00299 (/IDA) O00299 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O00299 (/IPI) O00299 (/IPI) O00299 (/IPI) O00299 (/IPI) O00299 (/IPI)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
5 O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA)
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2 Q9Z1Q5 (/ISO) Q9Z1Q5 (/ISO)
Voltage-gated chloride channel activity GO:0005247
Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 Q6MG61 (/TAS)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
5 O00299 (/IDA) O00299 (/IDA) O00299 (/IDA) O00299 (/IDA) O00299 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
5 O00299 (/TAS) O00299 (/TAS) O00299 (/TAS) O00299 (/TAS) O00299 (/TAS)
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
5 O00299 (/HMP) O00299 (/HMP) O00299 (/HMP) O00299 (/HMP) O00299 (/HMP)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9Z1Q5 (/ISO) Q9Z1Q5 (/ISO)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
2 Q9Z1Q5 (/IDA) Q9Z1Q5 (/IDA)
Regulation of mitochondrial membrane potential GO:0051881
Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
2 Q9Z1Q5 (/IDA) Q9Z1Q5 (/IDA)
Regulation of mitochondrial membrane potential GO:0051881
Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
2 Q9Z1Q5 (/IMP) Q9Z1Q5 (/IMP)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q6MG61 (/TAS)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 Q5E9B7 (/ISS) Q5E9B7 (/ISS) Q5E9B7 (/ISS) Q5E9B7 (/ISS) Q5E9B7 (/ISS) Q5E9B7 (/ISS) Q6MG61 (/ISS) Q95MF9 (/ISS) Q9Z1Q5 (/ISS) Q9Z1Q5 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 O00299 (/TAS) O00299 (/TAS) O00299 (/TAS) O00299 (/TAS) O00299 (/TAS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
5 O00299 (/IDA) O00299 (/IDA) O00299 (/IDA) O00299 (/IDA) O00299 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 O00299 (/IDA) O00299 (/IDA) O00299 (/IDA) O00299 (/IDA) O00299 (/IDA)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
5 O00299 (/TAS) O00299 (/TAS) O00299 (/TAS) O00299 (/TAS) O00299 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
5 O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
5 O00299 (/IDA) O00299 (/IDA) O00299 (/IDA) O00299 (/IDA) O00299 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 O00299 (/IDA) O00299 (/IDA) O00299 (/IDA) O00299 (/IDA) O00299 (/IDA)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
5 O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA) O00299 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9Z1Q5 (/IDA) Q9Z1Q5 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
2 Q9Z1Q5 (/ISO) Q9Z1Q5 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9Z1Q5 (/ISO) Q9Z1Q5 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q9Z1Q5 (/IDA) Q9Z1Q5 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 Q9Z1Q5 (/ISO) Q9Z1Q5 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q9Z1Q5 (/ISO) Q9Z1Q5 (/ISO)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q6MG61 (/TAS)
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