The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Glutaredoxin
".
FunFam 11: Peroxiredoxin PRX1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 21 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Peroxidase activity GO:0004601
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
|
21 |
A1Z893 (/ISS)
O77834 (/ISS)
O77834 (/ISS)
O77834 (/ISS)
O77834 (/ISS)
O77834 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
(11 more) |
Antioxidant activity GO:0016209
Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
|
16 |
Q5LN29 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
(6 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
11 |
O08709 (/IPI)
O08709 (/IPI)
O35244 (/IPI)
P30041 (/IPI)
P30041 (/IPI)
P30041 (/IPI)
P30041 (/IPI)
P30041 (/IPI)
P73348 (/IPI)
P73348 (/IPI)
(1 more) |
Thioredoxin peroxidase activity GO:0008379
Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.
|
11 |
P34227 (/IDA)
P34227 (/IDA)
P34227 (/IDA)
P34227 (/IDA)
P34227 (/IDA)
P34227 (/IDA)
P34227 (/IDA)
P34227 (/IDA)
P34227 (/IDA)
Q5A5A0 (/IDA)
(1 more) |
Thioredoxin peroxidase activity GO:0008379
Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.
|
9 | P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) |
Peroxidase activity GO:0004601
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
|
7 | A1Z892 (/IDA) Q7JX87 (/IDA) Q95SB0 (/IDA) Q9GPQ0 (/IDA) Q9GPQ1 (/IDA) Q9GPQ2 (/IDA) Q9VQI7 (/IDA) |
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
|
5 | P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) |
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
5 | P30041 (/IPI) P30041 (/IPI) P30041 (/IPI) P30041 (/IPI) P30041 (/IPI) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
5 | P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) |
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
5 | P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) |
Showing 1 to 10 of 21 entries
There are 28 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
17 |
A1Z893 (/ISS)
Q5LN29 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
Q8IAM2 (/ISS)
(7 more) |
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
9 | P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) P34227 (/IGI) |
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
|
9 | P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) |
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
|
9 | P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) |
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
|
9 | P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) P34227 (/IMP) |
Hydrogen peroxide catabolic process GO:0042744
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
|
8 | A1Z892 (/IDA) O35244 (/IDA) Q7JX87 (/IDA) Q95SB0 (/IDA) Q9GPQ0 (/IDA) Q9GPQ1 (/IDA) Q9GPQ2 (/IDA) Q9VQI7 (/IDA) |
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
|
5 | O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) |
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
5 | P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) P30041 (/IMP) |
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
5 | P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) |
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
5 | P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) |
Showing 1 to 10 of 28 entries
There are 20 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
24 |
A1Z892 (/IDA)
O08709 (/IDA)
O08709 (/IDA)
Q7JX87 (/IDA)
Q8IAM2 (/IDA)
Q8IAM2 (/IDA)
Q8IAM2 (/IDA)
Q8IAM2 (/IDA)
Q8IAM2 (/IDA)
Q8IAM2 (/IDA)
(14 more) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
12 |
O08709 (/HDA)
O08709 (/HDA)
P34227 (/HDA)
P34227 (/HDA)
P34227 (/HDA)
P34227 (/HDA)
P34227 (/HDA)
P34227 (/HDA)
P34227 (/HDA)
P34227 (/HDA)
(2 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
10 | A1Z893 (/ISS) O35244 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) Q2PFL9 (/ISS) Q5R7E0 (/ISS) Q9TSX9 (/ISS) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
9 | P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) P34227 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) Q5A5A0 (/IDA) Q5A5A0 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
7 | P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) P30041 (/IDA) Q5A5A0 (/IDA) Q5A5A0 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
5 | P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) P30041 (/TAS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
5 | P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) P30041 (/HDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) O77834 (/ISS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | P30041 (/NAS) P30041 (/NAS) P30041 (/NAS) P30041 (/NAS) P30041 (/NAS) |
Showing 1 to 10 of 20 entries