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CATH Superfamily 3.40.20.10

Severin

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Severin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Gelsolin
609
3D
 1nphA02 - 89.1
2
Gelsolin
585
3D
 4z94G01 - 85.1
4
Gelsolin
527
3D
 1nphA01 - 82.2
3
Protein transport protein SEC23
522
3D
 5vnoA05 - 85.6
5
Gelsolin
454
3D
 1nphA03 - 95.7
6
Protein transport protein SEC23
406
3D
 2qtvA05 - 82.8
7
Twinfilin-1 isoform 1
368
3D
 2w0iA00 - 96.8
8
gelsolin isoform X2
328
3D
 3ffnB03 - 73.0
9
gelsolin isoform X1
320
3D
 5fafA00 - 80.3
10
Putative destrin
315
3D
 5l6wC00 - 72.8
11
Drebrin-like protein B
257
3D
 1x67A01 - 91.9
12
Twinfilin-1 isoform 1
243
3D
 2vacA00 - 80.1
13
supervillin isoform X1
218 - - 33.3
14
Protein transport protein SEC23
217 - - 79.6
15
supervillin isoform X2
216 - - 43.5
16
supervillin isoform X2
215 - - 42.7
17
Supervillin
192 - - 45.5
18
Coactosin-like 1
189
3D
 1wnjA00 - 92.5
19
protein flightless-1 homolog isoform X1
177 - - 67.4
20
protein flightless-1 homolog isoform X1
173 - - 77.1
21
protein flightless-1 homolog isoform X2
170 - - 67.8
23
protein transport protein Sec24C isoform X1
164
3D
 5kyyB05 - 85.2
22
supervillin isoform X2
164 - - 31.3
24
Glia maturation factor
137
3D
 1v6fA00 - 76.8
29
SEC24 homolog B, COPII coat complex component
133
3D
 5vnoB05 - 62.3
25
Actin-depolymerizing factor 2
132
3D
 1f7sA00 - 86.7
26
Glia maturation factor
129
3D
 5ynrA00 - 96.2
27
Villin 1
123 - - 80.1
28
Villin-like 1
122 - - 76.5
30
protein flightless-1 homolog isoform X1
113 - - 59.1
31
protein flightless-1 homolog isoform X1
111 - - 87.5
32
Drebrin 1
105
3D
 5y1zB01 - 87.4
34
protein flightless-1 homolog isoform X1
99 - - 65.4
33
Villin-4
99 - - 87.3
35
Villin-1
88 - - 71.7
37
macrophage-capping protein-like isoform X2
85
3D
 1jhwA03 - 89.9
36
Protein transport protein SEC23
83 - - 56.0
39
Villin-4
77 - - 91.7
38
Villin-like 1
77 - - 86.9
40
macrophage-capping protein-like isoform X1
76
3D
 1jhwA02 - 74.2
41
Protein transport protein SEC23
72 - - 92.1
42
Actin depolymerizing protein
67 - - 97.9
43
macrophage-capping protein-like isoform X2
63 - - 88.5
44
Cofilin/actin-depolymerizing factor homolog
58
3D
 2mv2A00 - 70.6
45
Actin binding protein, putative
47 - - 75.0
52
Actin-binding protein
28
3D
 1hqz900 - 55.7
46
Cofilin/actin-depolymerizing factor like 1
27
3D
 3q2bA00 - 14.4
49
Vesicle coat component
27
3D
 1pd1A05 - 65.5
47
Villin like
25 - - 17.2
60
Cofilin
23
3D
 2i2qA00 - 52.0
48
Putative gmf family protein
23 - - 75.9
50
Villin like
21 - - 26.6
51
Actin-depolymerizing factor 2
20 - - 1.7
53
Villin like
18 - - 16.9
54
Protein transport protein SEC23
17 - - 79.8
57
Gelsolin, isoform A
16 - - 20.2
55
Quail, isoform C
16 - - 18.1
56
Quail, isoform C
16 - - 13.8
58
Quail, isoform C
15 - - 17.0
59
Villin-like 1
15 - - 45.3
62
Quail, isoform C
13 - - 16.1
61
Quail, isoform C
13 - - 16.2
63
YDR063W-like protein
11 - - 33.4
66
Secretory 24AB, isoform A
11 - - 11.1
64
Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence
11 - - 10.4
65
Quail, isoform C
11 - - 15.5
69
Sfb3p
10 - - 13.0
68
TWF1p Twinfilin
10 - - 1.9
67
TWF1p Twinfilin
10 - - 0.0
70
Protein transport protein SEC23
10 - - 32.3
72
Villin-1
9 - - 12.8
73
Protein transport protein Sec24C, putative
9 - - 46.7
71
Unplaced genomic scaffold supercont1.257, whole genome shotgun sequence
9 - - 11.6
74
Protein transport protein Sec24A
9 - - 3.4
76
Villin-1
8 - - 8.6
79
Secretory 24CD, isoform C
8 - - 7.5
78
Macrophage-capping protein
8 - - 11.3
75
DreBriN 1/DreBriN-like
Where Drebrin is from Developmentally REgulated BRaIN protein
8 - - 23.5
77
Gelsolin, isoform A
8 - - 15.8
83
Coronin
7 - - 11.3
88
Uncharacterized protein
7 - - 3.9
89
Villin-1
7 - - 5.3
82
Coronin
7 - - 6.6
86
Actin-binding protein, cofilin/tropomyosin family protein
7 - - 0.8
80
Kinase c and casein kinase substrate in neurons protein
7 - - 6.8
87
Actin-binding protein, cofilin/tropomyosin family protein
7 - - 5.0
84
Drebrin 1
7 - - 23.5
85
Uncharacterized protein
7 - - 0.0
81
Uncharacterized protein
7 - - 8.7
92
Uncharacterized protein
6 - - 88.7
101
Actin-depolymerizing factor 2, isoform c
6
3D
 2lxxA00 - 9.6
93
Villin-like 1
6 - - 13.4
96
Protein transport protein SEC23
6 - - 2.3
90
Variant sh3 domain containing protein
6 - - 8.7
91
Map kinase phosphatase
6 - - 14.7
94
Actin-binding protein, cofilin/tropomyosin family protein
6 - - 0.0
95
Twinfilin
6 - - 14.7
99
Putative G-actin binding protein
5 - - 10.6
98
Coronin
5 - - 1.0
100
Uncharacterized protein
5 - - 2.8
103
Gelsolin, isoform J
5 - - 8.5
97
Gelsolin-like protein 1
5 - - 21.6
104
Gelsolin, isoform J
5 - - 12.6
105
Protein flightless-1 homolog
5 - - 19.0
102
VILL isoform 1
5 - - 3.0
110
Scinderin like a
4 - - 2.0
109
Scinderin like a
4 - - 1.0
107
Villin-like 1
4 - - 7.9
111
Protein tyrosine kinase, putative
4 - - 4.8
108
Villin-1
4 - - 8.8
112
BnaC03g35080D protein
4 - - 10.2
106
Hypothetical_protein_-_conserved
4 - - 9.2
113
Si:dkey-40c11.2
3 - - 25.6
117
GMF family protein
3 - - 0.0
119
Protein transport protein Sec24-like CEF
3 - - 11.5
116
Coactosin like F-actin binding protein 1
3 - - 3.8
114
YALI0B14102p
3 - - 0.0
115
Twinfilin
3 - - 10.6
118
Uncharacterized protein
3 - - 9.9
128
SD03793p
2 - - 10.3
138
Uncharacterized protein
2 - - 0.9
140
Protein transport protein SEC23
2 - - 5.0
124
Uncharacterized protein
2 - - 2.4
132
Uncharacterized protein
2 - - 0.0
135
Twinfilin-2
2 - - 0.0
126
Uncharacterized protein
2 - - 36.1
122
Drebrin-like protein
2 - - 22.7
136
Actin depolymerizing protein
2 - - 0.0
125
Cofilin-2
2 - - 34.6
134
TWF1 isoform 4
2 - - 0.0
131
Uncharacterized protein
2 - - 0.0
137
Protein tyrosine kinase, putative
2 - - 0.0
139
YALI0E34687p
2 - - 0.0
129
Cofilin-1A
2 - - 0.0
127
YALI0E33693p
2 - - 0.0
121
Gelsolin-like protein 1
2 - - 0.0
123
Uncharacterized protein
2 - - 0.9
120
Gelsolin-related protein of 125 kDa
2 - - 0.0
130
Uncharacterized protein
2 - - 38.3
133
YALI0E34687p
2 - - 0.0
164
ABR105Cp
1 - - 0.0
166
Uncharacterized protein
1 - - 0.0
143
Protein app1
1 - - 0.0
165
Uncharacterized protein
1 - - 0.0
153
Cofilin-4
1 - - 0.0
162
Protovillin
1 - - 0.0
150
Uncharacterized protein
1 - - 0.0
171
Adseverin
1 - - 0.0
147
Uncharacterized protein
Fragment
1 - - 0.0
149
Predicted protein
1 - - 0.0
173
Uncharacterized protein
1 - - 0.0
157
Glia maturation factor
1 - - 0.0
159
G-actin binding protein, putative
1 - - 0.0
168
Actin-depolymerizing factor 1, isoforms a/b
1 - - 0.0
141
Gelsolin-related protein of 125 kDa
1 - - 0.0
170
Predicted protein
1 - - 0.0
151
Uncharacterized protein
1 - - 0.0
145
Villidin
1 - - 0.0
163
Twinfilin
1 - - 0.0
152
Uncharacterized protein
1 - - 0.0
155
Cofilin-5
1 - - 0.0
142
Gelsolin-related protein of 125 kDa
1 - - 0.0
160
Uncharacterized protein
1 - - 0.0
154
Uncharacterized protein
1 - - 0.0
144
Uncharacterized protein
1 - - 0.0
146
Villidin
1 - - 0.0
156
Actin binding protein
Eurofung
1 - - 0.0
174
ABR105Cp
1 - - 0.0
176
Protein transport protein Sec24A, putative
1 - - 0.0
167
Predicted protein
1 - - 0.0
169
Uncharacterized protein
1 - - 0.0
172
Actin-depolymerizing factor 1, isoforms a/b
1 - - 0.0
175
Uncharacterized protein C4.03c
1 - - 0.0
148
Chromosome 1, whole genome shotgun sequence
1 - - 0.0
161
Protovillin
1 - - 0.0
158
Uncharacterized protein
1 - - 0.0
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