The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Metalloenzyme, LuxS/M16 peptidase-like
".
FunFam 7: Insulin-degrading enzyme
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 40 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
|
3 | P35559 (/ISS) Q24K02 (/ISS) Q9JHR7 (/ISS) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
3 | P35559 (/ISS) Q24K02 (/ISS) Q9JHR7 (/ISS) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
3 | P35559 (/ISS) Q24K02 (/ISS) Q9JHR7 (/ISS) |
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
|
2 | Q24K02 (/ISS) Q9JHR7 (/ISS) |
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
|
2 | P14735 (/IDA) P35559 (/IDA) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | P14735 (/IDA) P35559 (/IDA) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q24K02 (/ISS) Q9JHR7 (/ISS) |
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
|
1 | P35559 (/IPI) |
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
|
1 | Q9JHR7 (/ISO) |
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
|
1 | P14735 (/IDA) |
Showing 1 to 10 of 40 entries
There are 63 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Type B pancreatic cell development GO:0003323
The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
|
3 | A0A0R4IL71 (/IMP) A4QP10 (/IMP) A5A8J7 (/IMP) |
Bradykinin catabolic process GO:0010815
The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin.
|
3 | P35559 (/ISS) Q24K02 (/ISS) Q9JHR7 (/ISS) |
Antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885
The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
|
3 | P35559 (/ISS) Q24K02 (/ISS) Q9JHR7 (/ISS) |
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
|
3 | A0A0R4IL71 (/IMP) A4QP10 (/IMP) A5A8J7 (/IMP) |
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
|
3 | P35559 (/ISS) Q24K02 (/ISS) Q9JHR7 (/ISS) |
Amyloid-beta metabolic process GO:0050435
The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP).
|
3 | P35559 (/ISS) Q24K02 (/ISS) Q9JHR7 (/ISS) |
Amyloid-beta clearance GO:0097242
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
|
3 | P14735 (/IMP) P35559 (/IMP) Q9JHR7 (/IMP) |
Insulin catabolic process GO:1901143
The chemical reactions and pathways resulting in the breakdown of insulin.
|
3 | P35559 (/ISS) Q24K02 (/ISS) Q9JHR7 (/ISS) |
Pancreas regeneration GO:1990798
The regrowth of a destroyed pancreas.
|
3 | A0A0R4IL71 (/IMP) A4QP10 (/IMP) A5A8J7 (/IMP) |
Hormone catabolic process GO:0042447
The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
|
2 | P14735 (/IDA) P35559 (/IDA) |
Showing 1 to 10 of 63 entries
There are 32 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | P14735 (/IDA) P35559 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P14735 (/IDA) P35559 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P14735 (/IDA) P35559 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q24K02 (/ISS) Q9JHR7 (/ISS) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | P14735 (/IDA) P35559 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q9JHR7 (/ISO) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P14735 (/ISS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P14735 (/TAS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9JHR7 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P14735 (/IDA) |
Showing 1 to 10 of 32 entries