The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Protein Inhibitor Of Neuronal Nitric Oxide Synthase;
".
FunFam 1: Dynein light chain
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 22 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
506 |
O96860 (/IPI)
O96860 (/IPI)
O96860 (/IPI)
O96860 (/IPI)
O96860 (/IPI)
O96860 (/IPI)
O96860 (/IPI)
O96860 (/IPI)
O96860 (/IPI)
O96860 (/IPI)
(496 more) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
173 |
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
(163 more) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
151 |
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
(141 more) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
151 |
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
P63170 (/IDA)
(141 more) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
151 |
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
(141 more) |
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
|
151 |
P63170 (/IPI)
P63170 (/IPI)
P63170 (/IPI)
P63170 (/IPI)
P63170 (/IPI)
P63170 (/IPI)
P63170 (/IPI)
P63170 (/IPI)
P63170 (/IPI)
P63170 (/IPI)
(141 more) |
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
|
151 |
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
(141 more) |
Dynein intermediate chain binding GO:0045505
Interacting selectively and non-covalently with an intermediate chain of the dynein complex.
|
91 |
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
(81 more) |
Enzyme inhibitor activity GO:0004857
Binds to and stops, prevents or reduces the activity of an enzyme.
|
69 |
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
(59 more) |
Enzyme inhibitor activity GO:0004857
Binds to and stops, prevents or reduces the activity of an enzyme.
|
69 |
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
(59 more) |
Showing 1 to 10 of 22 entries
There are 43 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
|
151 |
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
(141 more) |
Macroautophagy GO:0016236
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
|
151 |
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
(141 more) |
Antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
|
151 |
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
(141 more) |
Intraciliary transport involved in cilium assembly GO:0035735
The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.
|
151 |
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
(141 more) |
Motile cilium assembly GO:0044458
The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
|
72 |
P63168 (/IMP)
P63168 (/IMP)
P63168 (/IMP)
P63168 (/IMP)
P63168 (/IMP)
P63168 (/IMP)
P63168 (/IMP)
P63168 (/IMP)
P63168 (/IMP)
P63168 (/IMP)
(62 more) |
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
|
69 |
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
(59 more) |
Nitric oxide biosynthetic process GO:0006809
The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
|
69 |
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
P63170 (/TAS)
(59 more) |
Spermatid development GO:0007286
The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
|
69 |
P63170 (/IEP)
P63170 (/IEP)
P63170 (/IEP)
P63170 (/IEP)
P63170 (/IEP)
P63170 (/IEP)
P63170 (/IEP)
P63170 (/IEP)
P63170 (/IEP)
P63170 (/IEP)
(59 more) |
Regulation of G2/M transition of mitotic cell cycle GO:0010389
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
|
69 |
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
P63167 (/TAS)
(59 more) |
Substantia nigra development GO:0021762
The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).
|
69 |
P63167 (/HEP)
P63167 (/HEP)
P63167 (/HEP)
P63167 (/HEP)
P63167 (/HEP)
P63167 (/HEP)
P63167 (/HEP)
P63167 (/HEP)
P63167 (/HEP)
P63167 (/HEP)
(59 more) |
Showing 1 to 10 of 43 entries
There are 57 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
|
379 |
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
(369 more) |
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
|
345 |
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
(335 more) |
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
|
345 |
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
P61273 (/ISS)
(335 more) |
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
|
314 |
O94111 (/IDA)
O94111 (/IDA)
O94111 (/IDA)
P61285 (/IDA)
P61285 (/IDA)
P61285 (/IDA)
P61285 (/IDA)
P61285 (/IDA)
P61285 (/IDA)
P61285 (/IDA)
(304 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
194 |
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
(184 more) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
164 |
Q78P75 (/IDA)
Q78P75 (/IDA)
Q78P75 (/IDA)
Q78P75 (/IDA)
Q78P75 (/IDA)
Q78P75 (/IDA)
Q78P75 (/IDA)
Q78P75 (/IDA)
Q78P75 (/IDA)
Q78P75 (/IDA)
(154 more) |
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
|
154 |
O94111 (/IPI)
O94111 (/IPI)
O94111 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
P63168 (/IPI)
(144 more) |
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
|
152 |
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
(142 more) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
151 |
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
P63167 (/IDA)
(141 more) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
151 |
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
P63168 (/ISO)
(141 more) |
Showing 1 to 10 of 57 entries