The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Potassium Channel Kv1.1; Chain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 91: Lola, isoform F

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P17789 (/IPI) P17789 (/IPI) P42282 (/IPI) P42282 (/IPI) Q9V5M3 (/IPI) Q9V5M6 (/IPI)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
4 P17789 (/IDA) P17789 (/IDA) P42282 (/IDA) P42282 (/IDA)
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
4 P17789 (/IDA) P17789 (/IDA) P42282 (/IDA) P42282 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P17789 (/IDA) P17789 (/IDA) P42282 (/IDA) P42282 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
4 M9PJM9 (/IDA) P17789 (/IDA) P17789 (/IDA) Q0EEE4 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 P17789 (/IDA) P17789 (/IDA) P42282 (/IDA) P42282 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P42282 (/IDA) P42282 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 Q9V5M3 (/ISS) Q9V5M6 (/ISS)
POZ domain binding GO:0031208
Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.
2 P42282 (/IDA) P42282 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P17789 (/IPI) P17789 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 M9PJM9 (/IDA) Q0EEE4 (/IDA)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
2 P17789 (/IDA) P17789 (/IDA)

There are 48 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
4 P17789 (/TAS) P17789 (/TAS) P42282 (/TAS) P42282 (/TAS)
Tracheal outgrowth, open tracheal system GO:0007426
The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Regulation of embryonic cell shape GO:0016476
Any process that modulates the surface configuration of an embryonic cell.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Dorsal trunk growth, open tracheal system GO:0035001
Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Branch fusion, open tracheal system GO:0035147
Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Regulation of tube size, open tracheal system GO:0035151
Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Chitin-based cuticle development GO:0040003
Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Compound eye cone cell differentiation GO:0042675
The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Regulation of compound eye cone cell fate specification GO:0042682
Any process that mediates the specification of a cell into a compound eye cone cell.
4 P17789 (/IGI) P17789 (/IGI) P42282 (/IGI) P42282 (/IGI)
Regulation of compound eye cone cell fate specification GO:0042682
Any process that mediates the specification of a cell into a compound eye cone cell.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Positive regulation of DNA binding GO:0043388
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
4 P17789 (/IDA) P17789 (/IDA) P42282 (/IDA) P42282 (/IDA)
R7 cell development GO:0045467
The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium.
4 P17789 (/IMP) P17789 (/IMP) Q9V5M3 (/IMP) Q9V5M6 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
4 P17789 (/IDA) P17789 (/IDA) P42282 (/IDA) P42282 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
4 P17789 (/IGI) P17789 (/IGI) P42282 (/IGI) P42282 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 P17789 (/IDA) P17789 (/IDA) P42282 (/IDA) P42282 (/IDA)
Dorsal appendage formation GO:0046843
Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
R1/R6 development GO:0048053
The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Myoblast fate specification GO:0048626
The process in which a cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Compound eye corneal lens morphogenesis GO:0048750
The process in which the anatomical structures of the compound eye corneal lens are generated and organized.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Branching involved in open tracheal system development GO:0060446
The process in which the anatomical structures of branches in the open tracheal system are generated and organized.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Positive regulation of border follicle cell migration GO:1903688
Any process that activates or increases the frequency, rate or extent of border follicle cell migration.
4 P17789 (/IMP) P17789 (/IMP) P42282 (/IMP) P42282 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 Q9V5M3 (/IMP) Q9V5M6 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 M9PJM9 (/IMP) Q0EEE4 (/IMP)
Female meiotic nuclear division GO:0007143
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.
2 M9PJM9 (/IMP) Q0EEE4 (/IMP)
Gamete generation GO:0007276
The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
2 M9PJM9 (/IMP) Q0EEE4 (/IMP)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
2 Q9V5M3 (/IMP) Q9V5M6 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 Q9V5M3 (/IGI) Q9V5M6 (/IGI)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 Q9V5M3 (/IMP) Q9V5M6 (/IMP)
R3/R4 cell fate commitment GO:0007464
The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres.
2 Q9V5M3 (/IMP) Q9V5M6 (/IMP)
Larval somatic muscle development GO:0007526
The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.
2 Q9V5M3 (/IEP) Q9V5M6 (/IEP)
Larval somatic muscle development GO:0007526
The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.
2 Q9V5M3 (/IMP) Q9V5M6 (/IMP)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
2 Q9V5M3 (/IMP) Q9V5M6 (/IMP)
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
2 Q9V5M3 (/IGI) Q9V5M6 (/IGI)
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
2 Q9V5M3 (/IMP) Q9V5M6 (/IMP)
Antimicrobial humoral response GO:0019730
An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
2 Q9V5M3 (/IMP) Q9V5M6 (/IMP)
Sperm chromatin decondensation GO:0035041
Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus.
2 M9PJM9 (/IMP) Q0EEE4 (/IMP)
Larval lymph gland hemopoiesis GO:0035167
The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.
2 Q9V5M3 (/IMP) Q9V5M6 (/IMP)
Enteroendocrine cell differentiation GO:0035883
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.
2 P42282 (/IMP) P42282 (/IMP)
Regulation of imaginal disc-derived wing size GO:0044719
Any process that modulates the size of an imaginal disc-derived wing.
2 Q9V5M3 (/IMP) Q9V5M6 (/IMP)
Nurse cell apoptotic process GO:0045476
Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process.
2 Q9V5M3 (/IMP) Q9V5M6 (/IMP)
Sevenless signaling pathway GO:0045500
A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P42282 (/IPI) P42282 (/IPI)
Negative regulation of R7 cell differentiation GO:0045677
Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation.
2 P42282 (/IMP) P42282 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q9V5M3 (/ISS) Q9V5M6 (/ISS)
Negative regulation of photoreceptor cell differentiation GO:0046533
Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.
2 P42282 (/IMP) P42282 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
2 Q9V5M3 (/IMP) Q9V5M6 (/IMP)
Regulation of chromatin organization GO:1902275
Any process that modulates the frequency, rate or extent of chromatin organization.
2 M9PJM9 (/IMP) Q0EEE4 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 M9PJM9 (/IDA) P17789 (/IDA) P17789 (/IDA) P42282 (/IDA) P42282 (/IDA) Q0EEE4 (/IDA) Q9V5M3 (/IDA) Q9V5M6 (/IDA)
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
4 P17789 (/IDA) P17789 (/IDA) P42282 (/IDA) P42282 (/IDA)
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
4 P17789 (/IPI) P17789 (/IPI) P42282 (/IPI) P42282 (/IPI)
Nuclear chromosome GO:0000228
A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
2 M9PJM9 (/IDA) Q0EEE4 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q9V5M3 (/HDA) Q9V5M6 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 M9PJM9 (/IDA) Q0EEE4 (/IDA)
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