The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.

Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.

Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity.

Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production.

Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

The lipid bilayer surrounding the endoplasmic reticulum.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

Cytoplasm situated near, or occurring around, the nucleus.

A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.