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CATH Superfamily 3.30.450.30

Dynein light chain 2a, cytoplasmic

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Dynein light chain 2a, cytoplasmic
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Profilin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 29 P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI)
(19 more)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
 11 P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI) P35080 (/IPI)
(1 more)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
 11 P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA)
(1 more)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
 11 P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA)
(1 more)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
 1 Q9EPC6 (/IDA)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of epithelial cell migration GO:0010633
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
 29 P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP)
(19 more)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
 29 P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP)
(19 more)
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
 29 P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP)
(19 more)
Negative regulation of ruffle assembly GO:1900028
Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.
 29 P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP)
(19 more)
Negative regulation of epithelial cell migration GO:0010633
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
 18 Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP)
(8 more)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
Positive regulation of actin filament bundle assembly GO:0032233
Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
Modification of postsynaptic actin cytoskeleton GO:0098885
Any process that modifies the structure of a postsynaptic actin cytoskeleton.
 18 Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA)
(8 more)
Modification of postsynaptic actin cytoskeleton GO:0098885
Any process that modifies the structure of a postsynaptic actin cytoskeleton.
 18 Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP)
(8 more)
Negative regulation of ruffle assembly GO:1900028
Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.
 18 Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO) Q9JJV2 (/ISO)
(8 more)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
 18 Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA)
(8 more)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
 18 Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP)
(8 more)
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
 11 P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA)
(1 more)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
 11 P35080 (/IGI) P35080 (/IGI) P35080 (/IGI) P35080 (/IGI) P35080 (/IGI) P35080 (/IGI) P35080 (/IGI) P35080 (/IGI) P35080 (/IGI) P35080 (/IGI)
(1 more)
Positive regulation of actin filament bundle assembly GO:0032233
Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.
 11 P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP) P35080 (/IMP)
(1 more)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
 11 P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA)
(1 more)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
 11 P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA) P35080 (/IDA)
(1 more)
Regulation of actin filament polymerization GO:0030833
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
 1 Q9EPC6 (/IDA)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 18 Q9JJV2 (/TAS) Q9JJV2 (/TAS) Q9JJV2 (/TAS) Q9JJV2 (/TAS) Q9JJV2 (/TAS) Q9JJV2 (/TAS) Q9JJV2 (/TAS) Q9JJV2 (/TAS) Q9JJV2 (/TAS) Q9JJV2 (/TAS)
(8 more)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
 18 Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA)
(8 more)
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
 18 Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA)
(8 more)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
 18 Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA)
(8 more)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
 18 Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA) Q9JJV2 (/IDA)
(8 more)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
 18 Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP) Q9JJV2 (/IMP)
(8 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
 11 P35080 (/HDA) P35080 (/HDA) P35080 (/HDA) P35080 (/HDA) P35080 (/HDA) P35080 (/HDA) P35080 (/HDA) P35080 (/HDA) P35080 (/HDA) P35080 (/HDA)
(1 more)
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