The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Kinase associated domain 1, KA1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Non-specific serine/threonine protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 34 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
AMP-activated protein kinase activity GO:0004679
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
21 P54645 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA)
(11 more)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
20 P54645 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS)
(10 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
20 P54645 (/IPI) P54646 (/IPI) P54646 (/IPI) P54646 (/IPI) P54646 (/IPI) P54646 (/IPI) P54646 (/IPI) P54646 (/IPI) P54646 (/IPI) P54646 (/IPI)
(10 more)
Histone serine kinase activity GO:0035174
Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
20 P54645 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS)
(10 more)
AMP-activated protein kinase activity GO:0004679
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
18 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(8 more)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
16 P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) Q13131 (/TAS)
(6 more)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
10 Q09137 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q2LAI0 (/IDA) Q2PUH1 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
9 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS)
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
9 P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA)
AMP-activated protein kinase activity GO:0004679
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
8 Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q8BRK8 (/TAS)
CAMP-dependent protein kinase activity GO:0004691
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP.
7 Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS)
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
7 Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS)
Tau-protein kinase activity GO:0050321
Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.
7 Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS)
AMP-activated protein kinase activity GO:0004679
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
5 P54645 (/IMP) Q09137 (/IMP) Q5EG47 (/IMP) Q7KK41 (/IMP) Q8BRK8 (/IMP)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 Q5EG47 (/IDA) Q8BRK8 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 P54645 (/IDA) Q09137 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
AMP-activated protein kinase activity GO:0004679
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
AMP-activated protein kinase activity GO:0004679
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 P54645 (/IDA) Q09137 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q2LAI0 (/IPI) Q2PUH1 (/IPI)
Histone serine kinase activity GO:0035174
Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
2 Q5EG47 (/IDA) Q8BRK8 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q8BRK8 (/EXP)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q8BRK8 (/IMP)
G protein-coupled receptor kinase activity GO:0004703
Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate.
1 Q7KK41 (/ISS)
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 Q8BRK8 (/ISO)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P54645 (/IPI)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q5EG47 (/ISO)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 Q5EG47 (/ISO)
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 Q09137 (/IDA)
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 Q8BRK8 (/ISO)
Eukaryotic elongation factor-2 kinase activator activity GO:0042557
Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase.
1 P54645 (/NAS)

There are 142 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
22 P54645 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS)
(12 more)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
22 P54645 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS)
(12 more)
Lipid biosynthetic process GO:0008610
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
20 P54645 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS)
(10 more)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
20 P54645 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS)
(10 more)
Cellular response to nutrient levels GO:0031669
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
20 P54645 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS)
(10 more)
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
20 P54645 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS)
(10 more)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
20 P54645 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS)
(10 more)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
20 P54645 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS)
(10 more)
Positive regulation of glycolytic process GO:0045821
Any process that activates or increases the frequency, rate or extent of glycolysis.
20 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(10 more)
Fatty acid homeostasis GO:0055089
Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.
20 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(10 more)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
20 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(10 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
16 P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) Q13131 (/TAS)
(6 more)
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
16 P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) Q13131 (/TAS)
(6 more)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
16 P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) Q13131 (/TAS)
(6 more)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
16 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(6 more)
Macroautophagy GO:0016236
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
16 P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) Q13131 (/TAS)
(6 more)
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
16 P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) Q13131 (/TAS)
(6 more)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
16 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(6 more)
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
16 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(6 more)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
16 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(6 more)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
16 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(6 more)
Regulation of signal transduction by p53 class mediator GO:1901796
Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
16 P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) Q13131 (/TAS)
(6 more)
Positive regulation of cellular protein localization GO:1903829
Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
16 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(6 more)
Negative regulation of tubulin deacetylation GO:1904428
Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.
16 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(6 more)
Positive regulation of peptidyl-lysine acetylation GO:2000758
Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation.
16 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(6 more)
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
13 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q09137 (/ISS)
(3 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
10 P54645 (/IDA) Q09137 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q8BRK8 (/IDA)
Carnitine shuttle GO:0006853
The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine.
9 P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS)
Response to gamma radiation GO:0010332
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
9 P54645 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q5RDH5 (/ISS)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
9 Q13131 (/IMP) Q13131 (/IMP) Q13131 (/IMP) Q13131 (/IMP) Q13131 (/IMP) Q13131 (/IMP) Q13131 (/IMP) Q5EG47 (/IMP) Q8BRK8 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
9 Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q2LAI0 (/IDA) Q2PUH1 (/IDA)
Positive regulation of macroautophagy GO:0016239
Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
9 P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS)
Heat generation GO:0031649
Any homeostatic process in which an organism produces heat, thereby raising its internal temperature.
9 A0A091G1U3 (/ISS) A1E4B7 (/ISS) A3RLM9 (/ISS) G1NG26 (/ISS) H0YVD1 (/ISS) H0YVD1 (/ISS) K7G581 (/ISS) R0JT95 (/ISS) U3JH39 (/ISS)
Regulation of fatty acid biosynthetic process GO:0042304
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.
9 P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS)
Negative regulation of lipid catabolic process GO:0050995
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
9 P54645 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q5RDH5 (/ISS)
Response to acadesine GO:1904101
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus.
9 A0A091G1U3 (/ISS) A1E4B7 (/ISS) A3RLM9 (/ISS) G1NG26 (/ISS) H0YVD1 (/ISS) H0YVD1 (/ISS) K7G581 (/ISS) R0JT95 (/ISS) U3JH39 (/ISS)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
7 Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
7 Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
7 Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA)
Positive regulation of cholesterol biosynthetic process GO:0045542
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
7 Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS)
Negative regulation of glucosylceramide biosynthetic process GO:0046318
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.
7 Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS) Q13131 (/NAS)
Motor behavior GO:0061744
The specific neuromuscular movement of a single organism in response to external or internal stimuli.
7 Q13131 (/IGI) Q13131 (/IGI) Q13131 (/IGI) Q13131 (/IGI) Q13131 (/IGI) Q13131 (/IGI) Q13131 (/IGI)
CAMKK-AMPK signaling cascade GO:0061762
A series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
7 Q13131 (/IC) Q13131 (/IC) Q13131 (/IC) Q13131 (/IC) Q13131 (/IC) Q13131 (/IC) Q13131 (/IC)
CAMKK-AMPK signaling cascade GO:0061762
A series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
7 Q13131 (/IMP) Q13131 (/IMP) Q13131 (/IMP) Q13131 (/IMP) Q13131 (/IMP) Q13131 (/IMP) Q13131 (/IMP)
CAMKK-AMPK signaling cascade GO:0061762
A series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
7 Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS)
Neuron cellular homeostasis GO:0070050
The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
7 Q13131 (/IGI) Q13131 (/IGI) Q13131 (/IGI) Q13131 (/IGI) Q13131 (/IGI) Q13131 (/IGI) Q13131 (/IGI)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
7 Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
4 Q28948 (/ISS) Q28948 (/ISS) Q5RD00 (/ISS) Q7KK41 (/ISS)
Cellular response to palmitoleic acid GO:1904927
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus.
4 W5PHS8 (/IDA) W5PHS9 (/IDA) W5PHS9 (/IDA) W5PHS9 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Lipid biosynthetic process GO:0008610
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
2 Q5EG47 (/IDA) Q8BRK8 (/IDA)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
2 Q2LAI0 (/IDA) Q2PUH1 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
2 P54645 (/IDA) Q09137 (/IDA)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Response to caffeine GO:0031000
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
2 P54645 (/IDA) Q09137 (/IDA)
Response to caffeine GO:0031000
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Heat generation GO:0031649
Any homeostatic process in which an organism produces heat, thereby raising its internal temperature.
2 Q2LAI0 (/IDA) Q2PUH1 (/IDA)
Cellular response to nutrient levels GO:0031669
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
2 Q5EG47 (/IDA) Q8BRK8 (/IDA)
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
2 Q5EG47 (/IMP) Q8BRK8 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
2 Q2LAI0 (/IDA) Q2PUH1 (/IDA)
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
2 Q5EG47 (/IDA) Q8BRK8 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 Q2LAI0 (/IDA) Q2PUH1 (/IDA)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
2 Q5EG47 (/IMP) Q8BRK8 (/IMP)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
2 Q5EG47 (/IMP) Q8BRK8 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q5EG47 (/IMP) Q8BRK8 (/IMP)
Positive regulation of glycolytic process GO:0045821
Any process that activates or increases the frequency, rate or extent of glycolysis.
2 P54645 (/IDA) Q09137 (/IDA)
Positive regulation of glycolytic process GO:0045821
Any process that activates or increases the frequency, rate or extent of glycolysis.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 P54645 (/IDA) Q09137 (/IDA)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Fatty acid homeostasis GO:0055089
Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.
2 P54645 (/IDA) Q09137 (/IDA)
Fatty acid homeostasis GO:0055089
Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Regulation of stress granule assembly GO:0062028
Any process that modulates the rate, frequency or extent of stress granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 P54645 (/IMP) Q09137 (/IMP)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
2 P54645 (/IMP) Q09137 (/IMP)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Cellular response to prostaglandin E stimulus GO:0071380
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Cellular response to organonitrogen compound GO:0071417
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
2 P54645 (/IEP) Q09137 (/IEP)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
2 P54645 (/IDA) Q09137 (/IDA)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Positive regulation of cellular protein localization GO:1903829
Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Response to acadesine GO:1904101
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus.
2 Q2LAI0 (/IDA) Q2PUH1 (/IDA)
Negative regulation of tubulin deacetylation GO:1904428
Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Positive regulation of peptidyl-lysine acetylation GO:2000758
Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 Q7KK41 (/IMP)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
1 Q7KK41 (/IMP)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
1 Q5EG47 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q7KK41 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P54645 (/NAS)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 Q7KK41 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q7KK41 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P54645 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q5EG47 (/ISO)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 Q7KK41 (/IMP)
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
1 Q5EG47 (/IMP)
Cold acclimation GO:0009631
Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.
1 P54645 (/IDA)
Cold acclimation GO:0009631
Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.
1 Q5EG47 (/ISO)
Response to gamma radiation GO:0010332
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
1 Q5EG47 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8BRK8 (/IMP)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q5EG47 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q5EG47 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q5EG47 (/ISO)
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
1 Q8BRK8 (/IMP)
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
1 Q8BRK8 (/IDA)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 P54645 (/NAS)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
1 Q09137 (/IDA)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
1 Q8BRK8 (/ISO)
Fatty acid oxidation GO:0019395
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
1 Q5EG47 (/IMP)
Sequestering of triglyceride GO:0030730
The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.
1 Q7KK41 (/IMP)
Regulation of peptidyl-serine phosphorylation GO:0033135
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.
1 Q5EG47 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q8BRK8 (/IMP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q5EG47 (/IMP)
Behavioral response to starvation GO:0042595
Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment.
1 Q7KK41 (/IMP)
Regulation of digestive system process GO:0044058
Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
1 Q7KK41 (/IMP)
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
1 Q7KK41 (/IMP)
Positive regulation of gluconeogenesis GO:0045722
Any process that activates or increases the frequency, rate or extent of gluconeogenesis.
1 P54645 (/NAS)
Negative regulation of cell size GO:0045792
Any process that reduces cell size.
1 Q7KK41 (/IMP)
Positive regulation of fatty acid oxidation GO:0046321
Any process that activates or increases the frequency, rate or extent of fatty acid oxidation.
1 P54645 (/NAS)
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
1 P54645 (/NAS)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
1 P54645 (/IMP)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
1 Q5EG47 (/ISO)
Positive regulation of skeletal muscle tissue development GO:0048643
Any process that activates, maintains or increases the rate of skeletal muscle tissue development.
1 Q5EG47 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
1 Q7KK41 (/IMP)
Negative regulation of lipid catabolic process GO:0050995
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
1 Q5EG47 (/IDA)
Regulation of vesicle-mediated transport GO:0060627
Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
1 P54645 (/IMP)
Regulation of vesicle-mediated transport GO:0060627
Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
1 Q5EG47 (/ISO)
Motor behavior GO:0061744
The specific neuromuscular movement of a single organism in response to external or internal stimuli.
1 Q5EG47 (/ISO)
CAMKK-AMPK signaling cascade GO:0061762
A series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
1 Q5EG47 (/ISO)
Neuron cellular homeostasis GO:0070050
The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
1 Q5EG47 (/ISO)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 P54645 (/IEP)
Cellular response to ethanol GO:0071361
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P54645 (/IEP)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P54645 (/IEP)
Response to camptothecin GO:1901563
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus.
1 Q5EG47 (/IMP)
Positive regulation of axon guidance GO:1902669
Any process that activates or increases the frequency, rate or extent of axon guidance.
1 Q7KK41 (/IGI)
Positive regulation of mitochondrial transcription GO:1903109
Any process that activates or increases the frequency, rate or extent of transcription occuring in the mitochondrion.
1 Q5EG47 (/IMP)
Positive regulation of protein targeting to mitochondrion GO:1903955
Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
1 Q5EG47 (/IMP)
Negative regulation of TORC1 signaling GO:1904262
Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
1 Q7KK41 (/IMP)

There are 38 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
19 A0A087WXX9 (/IDA) A0A087WXX9 (/IDA) A0A087WXX9 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA)
(9 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
18 P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) Q09137 (/TAS)
(8 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
18 P54645 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS)
(8 more)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
16 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(6 more)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
16 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(6 more)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
16 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) Q13131 (/ISS)
(6 more)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
12 A0A087WXX9 (/IDA) A0A087WXX9 (/IDA) A0A087WXX9 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA) P54646 (/IDA)
(2 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 P54645 (/IDA) Q09137 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q5EG47 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
9 A0A091G1U3 (/ISS) A1E4B7 (/ISS) A3RLM9 (/ISS) G1NG26 (/ISS) H0YVD1 (/ISS) H0YVD1 (/ISS) K7G581 (/ISS) R0JT95 (/ISS) U3JH39 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 P54645 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q5RDH5 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS) P54646 (/TAS)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
9 P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS) P54646 (/ISS)
Nucleotide-activated protein kinase complex GO:0031588
A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
9 Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q13131 (/ISS) Q5EG47 (/ISS) Q5RDH5 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA) Q13131 (/IDA)
Nucleotide-activated protein kinase complex GO:0031588
A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
7 Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS) Q13131 (/TAS)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
6 Q2LAI0 (/IDA) Q2PUH1 (/IDA) W5PHS8 (/IDA) W5PHS9 (/IDA) W5PHS9 (/IDA) W5PHS9 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q5EG47 (/IDA) Q7KK41 (/IDA) Q8BRK8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 P54645 (/IDA) Q09137 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 P54645 (/IMP) Q09137 (/IMP)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 P54645 (/IMP) Q09137 (/IMP)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Nucleotide-activated protein kinase complex GO:0031588
A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
2 P54645 (/IDA) Q09137 (/IDA)
Nucleotide-activated protein kinase complex GO:0031588
A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 P54645 (/IDA) Q09137 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 Q5EG47 (/IGI) Q8BRK8 (/IGI)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 P54645 (/IMP) Q09137 (/IMP)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 Q5EG47 (/ISO) Q8BRK8 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q8BRK8 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q5EG47 (/ISO)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
1 Q8BRK8 (/IDA)
Nucleotide-activated protein kinase complex GO:0031588
A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
1 Q7KK41 (/IC)
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