The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Kinase associated domain 1, KA1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: Non-specific serine/threonine protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
AMP-activated protein kinase activity GO:0004679
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
3 O18645 (/IDA) O18645 (/IDA) Q5U118 (/IDA)
AMP-activated protein kinase activity GO:0004679
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
G protein-coupled receptor kinase activity GO:0004703
Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate.
3 O18645 (/ISS) O18645 (/ISS) Q5U118 (/ISS)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
3 O18645 (/ISS) O18645 (/ISS) Q5U118 (/ISS)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
3 O18645 (/ISS) O18645 (/ISS) Q5U118 (/ISS)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
Sequestering of triglyceride GO:0030730
The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
Behavioral response to starvation GO:0042595
Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
Regulation of digestive system process GO:0044058
Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
Negative regulation of cell size GO:0045792
Any process that reduces cell size.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
Positive regulation of axon guidance GO:1902669
Any process that activates or increases the frequency, rate or extent of axon guidance.
3 O18645 (/IGI) O18645 (/IGI) Q5U118 (/IGI)
Negative regulation of TORC1 signaling GO:1904262
Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
3 O18645 (/IMP) O18645 (/IMP) Q5U118 (/IMP)
Positive regulation of lipophagy GO:1904504
Any process that activates or increases the frequency, rate or extent of lipophagy.
2 O18645 (/IMP) O18645 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O18645 (/IDA) O18645 (/IDA) Q5U118 (/IDA)
Nucleotide-activated protein kinase complex GO:0031588
A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
3 O18645 (/IC) O18645 (/IC) Q5U118 (/IC)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
2 O18645 (/IDA) O18645 (/IDA)
Basolateral part of cell GO:1990794
The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells.
2 O18645 (/IDA) O18645 (/IDA)
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