The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
TCP-1-like chaperonin intermediate domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: T-complex protein 1 subunit gamma

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P49368 (/IPI) P49368 (/IPI) P80318 (/IPI) P80318 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 P49368 (/HDA) P49368 (/HDA)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
2 P48605 (/ISS) P48605 (/ISS)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
2 P49368 (/TAS) P49368 (/TAS)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2 P48605 (/ISS) P48605 (/ISS)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2 P49368 (/TAS) P49368 (/TAS)
Binding of sperm to zona pellucida GO:0007339
The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.
2 P80318 (/IDA) P80318 (/IDA)
Terminal branching, open tracheal system GO:0007430
Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster.
2 P48605 (/HMP) P48605 (/HMP)
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
2 P49368 (/IMP) P49368 (/IMP)
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
2 P80318 (/ISO) P80318 (/ISO)
Lumen formation, open tracheal system GO:0035149
Creation of the central hole of a tube in an open tracheal system through which gases flow.
2 P48605 (/HMP) P48605 (/HMP)
Negative regulation of retinal cell programmed cell death GO:0046671
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina.
2 Q7T2P2 (/IMP) Q8JHI7 (/IMP)
Pore complex assembly GO:0046931
The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases.
2 P80318 (/IMP) P80318 (/IMP)
Embryonic eye morphogenesis GO:0048048
The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.
2 Q7T2P2 (/IMP) Q8JHI7 (/IMP)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
2 P49368 (/IMP) P49368 (/IMP)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
2 P80318 (/ISO) P80318 (/ISO)
Toxin transport GO:1901998
The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P80318 (/IMP) P80318 (/IMP)
Positive regulation of establishment of protein localization to telomere GO:1904851
Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere.
2 P49368 (/IMP) P49368 (/IMP)
Positive regulation of establishment of protein localization to telomere GO:1904851
Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere.
2 P80318 (/ISO) P80318 (/ISO)
Positive regulation of protein localization to Cajal body GO:1904871
Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body.
2 P49368 (/HMP) P49368 (/HMP)
Positive regulation of telomerase RNA localization to Cajal body GO:1904874
Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body.
2 P49368 (/HMP) P49368 (/HMP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
6 P49368 (/IDA) P49368 (/IDA) P80318 (/IDA) P80318 (/IDA) Q3T0K2 (/IDA) Q3T0K2 (/IDA)
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
5 P48605 (/ISS) P48605 (/ISS) Q4R963 (/ISS) Q5NVF9 (/ISS) Q6P502 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 B4DUR8 (/IDA) P49368 (/IDA) P49368 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 B4DUR8 (/IDA) P49368 (/IDA) P49368 (/IDA)
Zona pellucida receptor complex GO:0002199
A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.
2 P80318 (/IDA) P80318 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P80318 (/ISO) P80318 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P49368 (/TAS) P49368 (/TAS)
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
2 P80318 (/ISO) P80318 (/ISO)
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
2 P49368 (/TAS) P49368 (/TAS)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2 P49368 (/TAS) P49368 (/TAS)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
2 P49368 (/IDA) P49368 (/IDA)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
2 P80318 (/ISO) P80318 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P80318 (/ISO) P80318 (/ISO)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
2 P80318 (/HDA) P80318 (/HDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
2 P80318 (/IDA) P80318 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P49368 (/HDA) P49368 (/HDA)
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