The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Classic Zinc Finger
".
FunFam 74: Tripartite motif containing 66
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 53 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
14 |
A0A0B4KGE5 (/IDA)
A0A0B4KH12 (/IDA)
A0A0B4KHG7 (/IDA)
A0A0B4KHT0 (/IDA)
A8WHL4 (/IDA)
O15164 (/IDA)
O15164 (/IDA)
O15164 (/IDA)
Q13263 (/IDA)
Q13263 (/IDA)
(4 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
12 |
O15164 (/IPI)
O15164 (/IPI)
O15164 (/IPI)
Q13263 (/IPI)
Q13263 (/IPI)
Q62318 (/IPI)
Q62318 (/IPI)
Q64127 (/IPI)
Q924W6 (/IPI)
Q99PP7 (/IPI)
(2 more) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
7 | A0A0B4KGE5 (/ISS) A0A0B4KH12 (/ISS) A0A0B4KHG7 (/ISS) A0A0B4KHT0 (/ISS) A8WHL4 (/ISS) Q9U3Y7 (/ISS) Q9VDK5 (/ISS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
7 | A0A0B4KGE5 (/ISM) A0A0B4KH12 (/ISM) A0A0B4KHG7 (/ISM) A0A0B4KHT0 (/ISM) A8WHL4 (/ISM) Q9U3Y7 (/ISM) Q9VDK5 (/ISM) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
6 | O15164 (/IDA) O15164 (/IDA) O15164 (/IDA) Q62318 (/IDA) Q62318 (/IDA) Q64127 (/IDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
6 | O15164 (/IDA) O15164 (/IDA) O15164 (/IDA) Q13263 (/IDA) Q13263 (/IDA) Q64127 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
5 | O15164 (/IDA) O15164 (/IDA) O15164 (/IDA) Q13263 (/IDA) Q13263 (/IDA) |
|
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
|
4 | O15164 (/IPI) O15164 (/IPI) O15164 (/IPI) Q64127 (/IPI) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | Q13263 (/IDA) Q13263 (/IDA) Q62318 (/IDA) Q62318 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
4 | O08629 (/ISS) Q13263 (/ISS) Q13263 (/ISS) Q64127 (/ISS) |
Showing 1 to 10 of 53 entries
There are 89 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
8 | A0A0B4KGE5 (/ISS) A0A0B4KH12 (/ISS) A0A0B4KHG7 (/ISS) A0A0B4KHT0 (/ISS) A8WHL4 (/ISS) Q99PP7 (/ISS) Q9U3Y7 (/ISS) Q9VDK5 (/ISS) |
|
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
|
7 | A0A0B4KGE5 (/IMP) A0A0B4KH12 (/IMP) A0A0B4KHG7 (/IMP) A0A0B4KHT0 (/IMP) A8WHL4 (/IMP) Q9U3Y7 (/IMP) Q9VDK5 (/IMP) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
7 | A0A0B4KGE5 (/IMP) A0A0B4KH12 (/IMP) A0A0B4KHG7 (/IMP) A0A0B4KHT0 (/IMP) A8WHL4 (/IMP) Q9U3Y7 (/IMP) Q9VDK5 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
6 | Q13263 (/IDA) Q13263 (/IDA) Q62318 (/IDA) Q62318 (/IDA) Q64127 (/IDA) Q924W6 (/IDA) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
5 | O15164 (/IDA) O15164 (/IDA) O15164 (/IDA) Q64127 (/IDA) Q9UPN9 (/IDA) |
|
Positive regulation of methylation-dependent chromatin silencing GO:0090309
Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin.
|
5 | O08629 (/ISS) Q13263 (/ISS) Q13263 (/ISS) Q62318 (/ISS) Q62318 (/ISS) |
|
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
4 | O15164 (/IMP) O15164 (/IMP) O15164 (/IMP) Q64127 (/IMP) |
|
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
|
4 | O15164 (/IMP) O15164 (/IMP) O15164 (/IMP) Q64127 (/IMP) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
4 | Q13263 (/IDA) Q13263 (/IDA) Q62318 (/IDA) Q62318 (/IDA) |
|
Positive regulation of methylation-dependent chromatin silencing GO:0090309
Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin.
|
4 | Q13263 (/IMP) Q13263 (/IMP) Q62318 (/IMP) Q62318 (/IMP) |
Showing 1 to 10 of 89 entries
There are 19 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
18 |
A0A0B4KGE5 (/IDA)
A0A0B4KH12 (/IDA)
A0A0B4KHG7 (/IDA)
A0A0B4KHT0 (/IDA)
A8WHL4 (/IDA)
O15164 (/IDA)
O15164 (/IDA)
O15164 (/IDA)
Q13263 (/IDA)
Q13263 (/IDA)
(8 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
11 |
A0A024R784 (/IDA)
A0A024R784 (/IDA)
B5MCJ9 (/IDA)
O15016 (/IDA)
O15164 (/IDA)
O15164 (/IDA)
O15164 (/IDA)
Q13263 (/IDA)
Q13263 (/IDA)
Q62318 (/IDA)
(1 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q62318 (/ISO) Q62318 (/ISO) Q64127 (/ISO) Q99PP7 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | Q62318 (/ISO) Q62318 (/ISO) Q64127 (/ISO) Q924W6 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O08629 (/ISS) Q13263 (/ISS) Q13263 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O15164 (/TAS) O15164 (/TAS) O15164 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q13263 (/TAS) Q13263 (/TAS) Q9UPN9 (/TAS) |
|
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
|
3 | Q62318 (/IDA) Q62318 (/IDA) Q64127 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | O15164 (/TAS) O15164 (/TAS) O15164 (/TAS) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
3 | O08629 (/ISS) Q13263 (/ISS) Q13263 (/ISS) |
Showing 1 to 10 of 19 entries
