The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 105: B-cell CLL/lymphoma 6, member B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 A8KA13 (/IPI) O88282 (/IPI) O88282 (/IPI) P41182 (/IPI) P41182 (/IPI) P41183 (/IPI) P41183 (/IPI) P41183 (/IPI) P41183 (/IPI)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
6 O88282 (/IDA) O88282 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 O88282 (/IDA) O88282 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
6 O88282 (/IDA) O88282 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
6 P41182 (/IDA) P41182 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
6 E1B8E6 (/ISS) E1B8E6 (/ISS) Q5RB65 (/ISS) Q5RB65 (/ISS) Q5ZM39 (/ISS) Q5ZM39 (/ISS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
6 P41182 (/IDA) P41182 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
6 E1B8E6 (/ISS) E1B8E6 (/ISS) Q5RB65 (/ISS) Q5RB65 (/ISS) Q5ZM39 (/ISS) Q5ZM39 (/ISS)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 P41182 (/ISA) P41182 (/ISA) Q8N143 (/ISA) Q8N143 (/ISA) Q8N143 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 P41182 (/NAS) P41182 (/NAS) Q8N143 (/NAS) Q8N143 (/NAS) Q8N143 (/NAS)
Showing 1 to 10 of 19 entries

There are 83 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Retina morphogenesis in camera-type eye GO:0060042
The process in which the anatomical structure of the retina is generated and organized.
10 A0A2R8Q3C5 (/IGI) A0A2R8Q3C5 (/IGI) A0A2R8QM88 (/IGI) A0A2R8QM88 (/IGI) A0A2R8RQ09 (/IGI) A0A2R8RQ09 (/IGI) F1R5N6 (/IGI) F1R5N6 (/IGI) Q6PC08 (/IGI) Q6PC08 (/IGI)
Retina morphogenesis in camera-type eye GO:0060042
The process in which the anatomical structure of the retina is generated and organized.
10 A0A2R8Q3C5 (/IMP) A0A2R8Q3C5 (/IMP) A0A2R8QM88 (/IMP) A0A2R8QM88 (/IMP) A0A2R8RQ09 (/IMP) A0A2R8RQ09 (/IMP) F1R5N6 (/IMP) F1R5N6 (/IMP) Q6PC08 (/IMP) Q6PC08 (/IMP)
Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator.
10 A0A2R8Q3C5 (/IMP) A0A2R8Q3C5 (/IMP) A0A2R8QM88 (/IMP) A0A2R8QM88 (/IMP) A0A2R8RQ09 (/IMP) A0A2R8RQ09 (/IMP) F1R5N6 (/IMP) F1R5N6 (/IMP) Q6PC08 (/IMP) Q6PC08 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
8 O88282 (/IDA) O88282 (/IDA) P41182 (/IDA) P41182 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
6 E1B8E6 (/ISS) E1B8E6 (/ISS) Q5RB65 (/ISS) Q5RB65 (/ISS) Q5ZM39 (/ISS) Q5ZM39 (/ISS)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
6 E1B8E6 (/ISS) E1B8E6 (/ISS) Q5RB65 (/ISS) Q5RB65 (/ISS) Q5ZM39 (/ISS) Q5ZM39 (/ISS)
Negative regulation of cell-matrix adhesion GO:0001953
Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.
6 E1B8E6 (/ISS) E1B8E6 (/ISS) Q5RB65 (/ISS) Q5RB65 (/ISS) Q5ZM39 (/ISS) Q5ZM39 (/ISS)
Germinal center formation GO:0002467
The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.
6 E1B8E6 (/ISS) E1B8E6 (/ISS) Q5RB65 (/ISS) Q5RB65 (/ISS) Q5ZM39 (/ISS) Q5ZM39 (/ISS)
Negative regulation of type 2 immune response GO:0002829
Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.
6 E1B8E6 (/ISS) E1B8E6 (/ISS) Q5RB65 (/ISS) Q5RB65 (/ISS) Q5ZM39 (/ISS) Q5ZM39 (/ISS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
6 E1B8E6 (/ISS) E1B8E6 (/ISS) Q5RB65 (/ISS) Q5RB65 (/ISS) Q5ZM39 (/ISS) Q5ZM39 (/ISS)
Showing 1 to 10 of 83 entries

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 O88282 (/IDA) O88282 (/IDA) P41182 (/IDA) P41182 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA) P41183 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 E1B8E6 (/ISS) E1B8E6 (/ISS) Q5RB65 (/ISS) Q5RB65 (/ISS) Q5ZM39 (/ISS) Q5ZM39 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P41183 (/ISO) P41183 (/ISO) P41183 (/ISO) P41183 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 P41183 (/ISO) P41183 (/ISO) P41183 (/ISO) P41183 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
4 P41183 (/ISO) P41183 (/ISO) P41183 (/ISO) P41183 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P41182 (/IDA) P41182 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P41182 (/TAS) P41182 (/TAS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 P41182 (/IDA) P41182 (/IDA)
Showing 1 to 8 of 8 entries
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