The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"DYRK
".
FunFam 1: Dual specificity tyrosine-phosphorylation-regulate...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 22 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
6 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) Q5U4C9 (/ISS) Q5ZIU3 (/ISS) Q922Y0 (/ISS) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
4 | O43781 (/IDA) Q922Y0 (/IDA) Q92630 (/IDA) Q92630 (/IDA) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
4 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q5U4C9 (/ISS) Q5ZIU3 (/ISS) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
4 | O43781 (/IDA) Q922Y0 (/IDA) Q92630 (/IDA) Q92630 (/IDA) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
4 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q5U4C9 (/ISS) Q5ZIU3 (/ISS) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
3 | O43781 (/IDA) Q92630 (/IDA) Q92630 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q922Y0 (/IPI) Q92630 (/IPI) Q92630 (/IPI) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
2 | Q5U4C9 (/ISO) Q922Y0 (/ISO) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
2 | O43781 (/IDA) Q922Y0 (/IDA) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
2 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
2 | O43781 (/IMP) Q922Y0 (/IMP) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
2 | Q5U4C9 (/ISO) Q922Y0 (/ISO) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
2 | Q92630 (/TAS) Q92630 (/TAS) |
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
2 | Q92630 (/IDA) Q92630 (/IDA) |
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
2 | Q5U4C9 (/ISO) Q922Y0 (/ISO) |
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
2 | Q5U4C9 (/ISS) Q5ZIU3 (/ISS) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
2 | Q5U4C9 (/ISO) Q922Y0 (/ISO) |
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
|
2 | Q92630 (/IDA) Q92630 (/IDA) |
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
|
2 | Q5U4C9 (/ISS) Q5ZIU3 (/ISS) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | Q922Y0 (/ISO) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | O43781 (/TAS) |
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
|
1 | Q5U4C9 (/ISO) |
There are 42 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
5 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) Q5U4C9 (/ISS) Q5ZIU3 (/ISS) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
4 | O43781 (/IDA) Q922Y0 (/IDA) Q92630 (/IDA) Q92630 (/IDA) |
Nuclear speck organization GO:0035063
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized.
|
4 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) Q922Y0 (/ISS) |
Stress granule disassembly GO:0035617
The disaggregation of a stress granule into its constituent protein and RNA parts.
|
4 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) Q922Y0 (/ISS) |
Regulation of cellular response to stress GO:0080135
Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
4 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) Q922Y0 (/ISS) |
Positive regulation of cell cycle G2/M phase transition GO:1902751
Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.
|
4 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) Q922Y0 (/ISS) |
Organelle disassembly GO:1903008
The disaggregation of an organelle into its constituent components.
|
4 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) Q922Y0 (/ISS) |
Regulation of TORC1 signaling GO:1903432
Any process that modulates the frequency, rate or extent of TORC1 signaling.
|
4 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) Q922Y0 (/ISS) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
3 | O43781 (/TAS) Q92630 (/TAS) Q92630 (/TAS) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
3 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
2 | Q5U4C9 (/ISO) Q922Y0 (/ISO) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
2 | Q92630 (/IEP) Q92630 (/IEP) |
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
|
2 | Q92630 (/IMP) Q92630 (/IMP) |
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
|
2 | Q5U4C9 (/ISO) Q922Y0 (/ISO) |
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
2 | O43781 (/IDA) Q922Y0 (/IDA) |
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
2 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) |
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
2 | Q92630 (/IDA) Q92630 (/IDA) |
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
2 | Q5U4C9 (/ISS) Q5ZIU3 (/ISS) |
Positive regulation of glycogen biosynthetic process GO:0045725
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
|
2 | Q92630 (/IDA) Q92630 (/IDA) |
Positive regulation of glycogen biosynthetic process GO:0045725
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
|
2 | Q5U4C9 (/ISS) Q5ZIU3 (/ISS) |
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
|
2 | Q92630 (/IMP) Q92630 (/IMP) |
Regulation of signal transduction by p53 class mediator GO:1901796
Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
|
2 | Q92630 (/TAS) Q92630 (/TAS) |
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
|
1 | Q5U4C9 (/ISO) |
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
1 | Q922Y0 (/ISO) |
Nuclear speck organization GO:0035063
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized.
|
1 | O43781 (/IDA) |
Nuclear speck organization GO:0035063
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized.
|
1 | Q922Y0 (/ISO) |
Stress granule disassembly GO:0035617
The disaggregation of a stress granule into its constituent protein and RNA parts.
|
1 | O43781 (/IDA) |
Stress granule disassembly GO:0035617
The disaggregation of a stress granule into its constituent protein and RNA parts.
|
1 | O43781 (/IMP) |
Stress granule disassembly GO:0035617
The disaggregation of a stress granule into its constituent protein and RNA parts.
|
1 | Q922Y0 (/ISO) |
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
1 | Q5U4C9 (/ISO) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q922Y0 (/IMP) |
Negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518
Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
|
1 | Q922Y0 (/IMP) |
Positive regulation of glycogen biosynthetic process GO:0045725
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
|
1 | Q5U4C9 (/ISO) |
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
|
1 | Q5U4C9 (/ISO) |
Regulation of cellular response to stress GO:0080135
Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
1 | O43781 (/IMP) |
Regulation of cellular response to stress GO:0080135
Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
1 | Q922Y0 (/ISO) |
Positive regulation of cell cycle G2/M phase transition GO:1902751
Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.
|
1 | O43781 (/IDA) |
Positive regulation of cell cycle G2/M phase transition GO:1902751
Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.
|
1 | Q922Y0 (/ISO) |
Organelle disassembly GO:1903008
The disaggregation of an organelle into its constituent components.
|
1 | O43781 (/IDA) |
Organelle disassembly GO:1903008
The disaggregation of an organelle into its constituent components.
|
1 | Q922Y0 (/ISO) |
Regulation of TORC1 signaling GO:1903432
Any process that modulates the frequency, rate or extent of TORC1 signaling.
|
1 | O43781 (/IMP) |
Regulation of TORC1 signaling GO:1903432
Any process that modulates the frequency, rate or extent of TORC1 signaling.
|
1 | Q922Y0 (/ISO) |
There are 26 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) Q5U4C9 (/ISS) Q5ZIU3 (/ISS) Q922Y0 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q5U4C9 (/ISS) Q5ZIU3 (/ISS) Q922Y0 (/ISS) |
Pericentriolar material GO:0000242
A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.
|
4 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) Q922Y0 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | O43781 (/IDA) Q5SY34 (/IDA) Q92630 (/IDA) Q92630 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | O43781 (/IDA) Q5SY34 (/IDA) Q92630 (/IDA) Q92630 (/IDA) |
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
4 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) Q922Y0 (/ISS) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
4 | Q4R6S5 (/ISS) Q4R6S5 (/ISS) Q4V8A3 (/ISS) Q922Y0 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O43781 (/IDA) Q92630 (/IDA) Q92630 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | O43781 (/IDA) Q92630 (/IDA) Q92630 (/IDA) |
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
2 | Q92630 (/IDA) Q92630 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q5U4C9 (/ISO) Q922Y0 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q5U4C9 (/ISO) Q922Y0 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q92630 (/TAS) Q92630 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q5U4C9 (/ISO) Q922Y0 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q92630 (/TAS) Q92630 (/TAS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q5U4C9 (/ISO) Q922Y0 (/ISO) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | O43781 (/IDA) Q5SY34 (/IDA) |
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
1 | Q5U4C9 (/ISO) |
Pericentriolar material GO:0000242
A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.
|
1 | O43781 (/IDA) |
Pericentriolar material GO:0000242
A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.
|
1 | Q922Y0 (/ISO) |
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
1 | O43781 (/IDA) |
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
1 | Q922Y0 (/ISO) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | O43781 (/IDA) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q922Y0 (/ISO) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | Q922Y0 (/ISO) |
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
1 | Q5U4C9 (/IDA) |