The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: 5-methyltetrahydropteroyltriglutamate--homocystein...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Methionine synthase activity GO:0008705
Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.
20 O50008 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA)
(10 more)
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GO:0003871
Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
18 P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA)
(8 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
17 O50008 (/IPI) P25665 (/IPI) P25665 (/IPI) P25665 (/IPI) P25665 (/IPI) P25665 (/IPI) P25665 (/IPI) P25665 (/IPI) P25665 (/IPI) P25665 (/IPI)
(7 more)
Protein methyltransferase activity GO:0008276
Catalysis of the transfer of a methyl group (CH3-) to a protein.
16 P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA)
(6 more)
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GO:0003871
Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
9 P82610 (/ISS) P82610 (/ISS) Q54X49 (/ISS) Q8EIM0 (/ISS) Q9KRD8 (/ISS) Q9KRD8 (/ISS) Q9KRD8 (/ISS) Q9KRD8 (/ISS) Q9KRD8 (/ISS)
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GO:0003871
Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
5 P05694 (/IMP) P05694 (/IMP) P05694 (/IMP) P05694 (/IMP) Q9UT19 (/IMP)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 O50008 (/IDA) P82610 (/IDA) P82610 (/IDA)
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GO:0003871
Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
2 P82610 (/IGI) P82610 (/IGI)
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GO:0003871
Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
2 C8V8J7 (/RCA) C8V8J7 (/RCA)
Methionine synthase activity GO:0008705
Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.
2 C8V8J7 (/IMP) C8V8J7 (/IMP)
Methionine synthase activity GO:0008705
Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.
2 C8V8J7 (/RCA) C8V8J7 (/RCA)
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GO:0003871
Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
1 Q57XC8 (/ISM)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
1 O50008 (/IDA)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
16 P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA)
(6 more)
Tetrahydrofolate interconversion GO:0035999
The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.
16 P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA)
(6 more)
Homocysteine metabolic process GO:0050667
The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.
16 P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA)
(6 more)
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
8 C8V8J7 (/IMP) C8V8J7 (/IMP) P05694 (/IMP) P05694 (/IMP) P05694 (/IMP) P05694 (/IMP) P82610 (/IMP) P82610 (/IMP)
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
7 Q54X49 (/ISS) Q8EIM0 (/ISS) Q9KRD8 (/ISS) Q9KRD8 (/ISS) Q9KRD8 (/ISS) Q9KRD8 (/ISS) Q9KRD8 (/ISS)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
3 O50008 (/IEP) Q9SRV5 (/IEP) Q9SRV5 (/IEP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
3 O50008 (/IEP) Q9SRV5 (/IEP) Q9SRV5 (/IEP)
Methionine metabolic process GO:0006555
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
2 P82610 (/IDA) P82610 (/IDA)
Methionine metabolic process GO:0006555
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
2 P82610 (/IGI) P82610 (/IGI)
Methionine metabolic process GO:0006555
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
2 C8V8J7 (/RCA) C8V8J7 (/RCA)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 P82610 (/IEP) P82610 (/IEP)
Induction by symbiont of host defense response GO:0044416
The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2 P82610 (/IDA) P82610 (/IDA)
Cysteine metabolic process GO:0006534
The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.
1 Q9UT19 (/NAS)
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
1 Q57XC8 (/ISM)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 O50008 (/IEP)
L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine GO:0019280
The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine.
1 Q9UT19 (/IMP)
Adenine biosynthetic process GO:0046084
The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.
1 Q9UT19 (/IMP)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
20 O50008 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA) P25665 (/IDA)
(10 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 P05694 (/HDA) P05694 (/HDA) P05694 (/HDA) P05694 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) Q9UT19 (/HDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
7 P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA) P9WK07 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P05694 (/HDA) P05694 (/HDA) P05694 (/HDA) P05694 (/HDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
4 O50008 (/IDA) Q0WNZ5 (/IDA) Q9SRV5 (/IDA) Q9SRV5 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O50008 (/IDA) Q9SRV5 (/IDA) Q9SRV5 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
3 O50008 (/IDA) Q9SRV5 (/IDA) Q9SRV5 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
3 O50008 (/IDA) Q9SRV5 (/IDA) Q9SRV5 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 C8V8J7 (/IDA) C8V8J7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P82610 (/IDA) P82610 (/IDA)
Fungal-type cell wall GO:0009277
A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure.
2 P82610 (/IDA) P82610 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
2 Q9SRV5 (/IDA) Q9SRV5 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P82610 (/IDA) P82610 (/IDA)
Hyphal cell wall GO:0030446
The cell wall surrounding a fungal hypha.
2 P82610 (/IDA) P82610 (/IDA)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
2 P82610 (/IDA) P82610 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9UT19 (/HDA)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
1 O50008 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 O50008 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 O50008 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O50008 (/IDA)
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