The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 93: NSFL1 (P97) cofactor (P47)

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 O35987 (/IPI) Q9CZ44 (/IPI) Q9UNZ2 (/IPI) Q9UNZ2 (/IPI) Q9UNZ2 (/IPI) Q9UNZ2 (/IPI) Q9UNZ2 (/IPI) Q9UNZ2 (/IPI)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
1 O35987 (/IDA)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
1 Q9CZ44 (/ISO)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 O35987 (/IPI)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 Q9CZ44 (/ISO)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
6 Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI)
Positive regulation of mitotic centrosome separation GO:0046604
Any process that activates or increases the frequency, rate or extent of centrosome separation.
6 Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI)
Negative regulation of protein localization to centrosome GO:1904780
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome.
6 Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI)
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
1 Q9CZ44 (/ISO)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
1 O35987 (/IDA)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
1 Q9CZ44 (/ISO)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
1 Q5ZK10 (/ISS)
Positive regulation of mitotic centrosome separation GO:0046604
Any process that activates or increases the frequency, rate or extent of centrosome separation.
1 Q9CZ44 (/ISO)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 O35987 (/IDA)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 Q9CZ44 (/ISO)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 Q5ZK10 (/ISS)
Negative regulation of protein localization to centrosome GO:1904780
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome.
1 Q9CZ44 (/ISO)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 O35987 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
6 Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA)
VCP-NSFL1C complex GO:1990730
A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.
6 Q9UNZ2 (/ISS) Q9UNZ2 (/ISS) Q9UNZ2 (/ISS) Q9UNZ2 (/ISS) Q9UNZ2 (/ISS) Q9UNZ2 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9CZ44 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9CZ44 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9CZ44 (/ISO)
Spindle pole centrosome GO:0031616
A centrosome from which one pole of a mitotic or meiotic spindle is organized.
1 O35987 (/IDA)
Spindle pole centrosome GO:0031616
A centrosome from which one pole of a mitotic or meiotic spindle is organized.
1 Q9CZ44 (/ISO)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
1 Q9CZ44 (/ISO)
VCP-NSFL1C complex GO:1990730
A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.
1 O35987 (/IPI)
VCP-NSFL1C complex GO:1990730
A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.
1 Q9CZ44 (/ISO)
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