The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 889: A-Raf proto-oncogene, serine/threonine kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
1 A0A0A1GUM7 (/IDA)

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pathway-restricted SMAD protein phosphorylation GO:0060389
The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor.
1 A0A0A1GUM7 (/IDA)
Negative regulation of nodal signaling pathway GO:1900108
Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway.
1 A0A0A1GUM7 (/IDA)
Negative regulation of nodal signaling pathway GO:1900108
Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway.
1 A0A0A1GUM7 (/IMP)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
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