View in Gene3D

CATH Superfamily 3.10.20.90

Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 87: Inhibitor of nuclear factor kappa B kinase subunit...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
I-kappa-B kinase. [EC: 2.7.11.10]
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
  • Phosphorylates I-kappa-B proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway.
  • Subsequent degradation of the I-kappa-B complex (IKK) activates NF-kappa-B, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis.
  • If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
  • Formerly EC 2.7.1.37.
 7 L8I6C2 L8I6C2 O14920 O88351 Q95KV0 Q95KV0 Q9QY78
CATH-Gene3D is a Global Biodata Core Resource Learn more...