CATH Superfamily 3.10.20.770
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 1: Phosphatidylinositol 4,5-bisphosphate 3-kinase cat...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P48736 (/IPI) P48736 (/IPI) Q9JHG7 (/IPI) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
2 | P48736 (/IDA) P48736 (/IDA) |
1-phosphatidylinositol-3-kinase activity GO:0016303
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
|
2 | P48736 (/TAS) P48736 (/TAS) |
Phosphatidylinositol 3-kinase activity GO:0035004
Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | P48736 (/IPI) P48736 (/IPI) |
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
|
2 | P48736 (/IPI) P48736 (/IPI) |
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | Q9JHG7 (/ISO) |
1-phosphatidylinositol-3-kinase activity GO:0016303
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
|
1 | D3ZFJ0 (/IDA) |
1-phosphatidylinositol-3-kinase activity GO:0016303
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
|
1 | Q9JHG7 (/ISO) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q9JHG7 (/ISO) |
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
|
1 | Q9JHG7 (/ISO) |
There are 50 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Adaptive immune response GO:0002250
An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
|
2 | P48736 (/TAS) P48736 (/TAS) |
Dendritic cell chemotaxis GO:0002407
The movement of a dendritic cell in response to an external stimulus.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Respiratory burst involved in defense response GO:0002679
A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Phosphatidylinositol biosynthetic process GO:0006661
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
2 | P48736 (/TAS) P48736 (/TAS) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
2 | P48736 (/IDA) P48736 (/IDA) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
2 | P48736 (/TAS) P48736 (/TAS) |
T cell chemotaxis GO:0010818
The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Phosphatidylinositol 3-kinase signaling GO:0014065
A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
|
2 | P48736 (/IDA) P48736 (/IDA) |
Phosphatidylinositol 3-kinase signaling GO:0014065
A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
2 | P48736 (/IDA) P48736 (/IDA) |
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
2 | F1QVE6 (/IMP) Q6NTI2 (/IMP) |
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Natural killer cell chemotaxis GO:0035747
The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
2 | P48736 (/TAS) P48736 (/TAS) |
T cell proliferation GO:0042098
The expansion of a T cell population by cell division. Follows T cell activation.
|
2 | P48736 (/TAS) P48736 (/TAS) |
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Mast cell degranulation GO:0043303
The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
|
2 | P48736 (/IDA) P48736 (/IDA) |
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
2 | P48736 (/IDA) P48736 (/IDA) |
Negative regulation of cardiac muscle contraction GO:0055118
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Neutrophil extravasation GO:0072672
The migration of a neutrophil from the blood vessels into the surrounding tissue.
|
2 | P48736 (/TAS) P48736 (/TAS) |
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
|
1 | Q9JHG7 (/IMP) |
Positive regulation of acute inflammatory response GO:0002675
Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
|
1 | D3ZFJ0 (/IMP) |
Positive regulation of acute inflammatory response GO:0002675
Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
|
1 | Q9JHG7 (/ISO) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | Q9JHG7 (/IDA) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
1 | Q9JHG7 (/ISO) |
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | D3ZFJ0 (/IMP) |
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | Q9JHG7 (/ISO) |
Negative regulation of triglyceride catabolic process GO:0010897
Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
|
1 | D3ZFJ0 (/IMP) |
Negative regulation of triglyceride catabolic process GO:0010897
Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
|
1 | Q9JHG7 (/ISO) |
Phosphatidylinositol 3-kinase signaling GO:0014065
A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
|
1 | Q9JHG7 (/ISO) |
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
1 | Q9JHG7 (/ISO) |
Secretory granule localization GO:0032252
Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.
|
1 | D3ZFJ0 (/IMP) |
Secretory granule localization GO:0032252
Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.
|
1 | Q9JHG7 (/ISO) |
Positive regulation of catalytic activity GO:0043085
Any process that activates or increases the activity of an enzyme.
|
1 | Q9JHG7 (/IMP) |
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
|
1 | Q9JHG7 (/ISO) |
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
|
1 | D3ZFJ0 (/IDA) |
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
|
1 | Q9JHG7 (/ISO) |
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | Q9JHG7 (/ISO) |
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
|
1 | Q9JHG7 (/IMP) |
Hepatocyte apoptotic process GO:0097284
Any apoptotic process in a hepatocyte, the main structural component of the liver.
|
1 | D3ZFJ0 (/IMP) |
Hepatocyte apoptotic process GO:0097284
Any apoptotic process in a hepatocyte, the main structural component of the liver.
|
1 | Q9JHG7 (/ISO) |
Regulation of calcium ion transmembrane transport GO:1903169
Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport.
|
1 | Q9JHG7 (/IMP) |
Negative regulation of fibroblast apoptotic process GO:2000270
Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.
|
1 | Q9JHG7 (/IDA) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | A0A024R720 (/IDA) A0A024R720 (/IDA) P48736 (/IDA) P48736 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P48736 (/TAS) P48736 (/TAS) Q9JHG7 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P48736 (/IDA) P48736 (/IDA) |
Phosphatidylinositol 3-kinase complex, class IB GO:0005944
A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
|
2 | P48736 (/IDA) P48736 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | P48736 (/HDA) P48736 (/HDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | P48736 (/IDA) P48736 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9JHG7 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9JHG7 (/ISO) |
Phosphatidylinositol 3-kinase complex GO:0005942
A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
|
1 | D3ZFJ0 (/IDA) |
Phosphatidylinositol 3-kinase complex GO:0005942
A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
|
1 | Q9JHG7 (/ISO) |
Phosphatidylinositol 3-kinase complex, class IB GO:0005944
A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
|
1 | Q9JHG7 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q9JHG7 (/ISO) |