The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cytochrome b5-like heme/steroid binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: membrane-associated progesterone receptor componen...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 O00264 (/IPI) O00264 (/IPI) O00264 (/IPI) O00264 (/IPI) O13995 (/IPI) O15173 (/IPI) Q6IB11 (/IPI) Q6IB11 (/IPI) Q6IB11 (/IPI) Q6IB11 (/IPI)
(1 more)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
11 O13995 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA)
(1 more)
Steroid binding GO:0005496
Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
5 O00264 (/TAS) O00264 (/TAS) O00264 (/TAS) O00264 (/TAS) O15173 (/TAS)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
4 O00264 (/TAS) O00264 (/TAS) O00264 (/TAS) O00264 (/TAS)
Steroid hormone receptor activity GO:0003707
Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
1 O15173 (/TAS)
Steroid binding GO:0005496
Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
1 O13995 (/ISM)
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
1 O13995 (/IMP)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
1 P70580 (/TAS)
Ecdysone binding GO:0035100
Interacting selectively and non-covalently with 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting.
1 Q9VXM4 (/IDA)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of ergosterol biosynthetic process GO:0032443
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.
18 Q12091 (/IMP) Q12091 (/IMP) Q12091 (/IMP) Q12091 (/IMP) Q12091 (/IMP) Q12091 (/IMP) Q12091 (/IMP) Q12091 (/IMP) Q12091 (/IMP) Q4WNM2 (/IMP)
(8 more)
Regulation of ergosterol biosynthetic process GO:0032443
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.
9 Q12091 (/IGI) Q12091 (/IGI) Q12091 (/IGI) Q12091 (/IGI) Q12091 (/IGI) Q12091 (/IGI) Q12091 (/IGI) Q12091 (/IGI) Q12091 (/IGI)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
4 O00264 (/TAS) O00264 (/TAS) O00264 (/TAS) O00264 (/TAS)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
2 O55022 (/ISO) O55022 (/ISO)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
2 O55022 (/ISO) O55022 (/ISO)
Modification of synaptic structure GO:0099563
Any process that modifies the structure/morphology of a synapse.
2 O55022 (/ISO) O55022 (/ISO)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
2 O55022 (/ISO) O55022 (/ISO)
Meiotic cell cycle process involved in oocyte maturation GO:1903537
Any meiotic cell cycle process that is involved in oocyte maturation.
2 G5E5M5 (/IMP) Q17QC0 (/IMP)
Negative regulation of synapse organization GO:1905809
Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization.
2 O55022 (/ISO) O55022 (/ISO)
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
1 O13995 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 P70580 (/IEP)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 P70580 (/IGI)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
1 P70580 (/IGI)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
1 Q5SSH8 (/IMP)
Modification of synaptic structure GO:0099563
Any process that modifies the structure/morphology of a synapse.
1 P70580 (/IGI)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
1 P70580 (/IMP)
Regulation of meiotic cell cycle process involved in oocyte maturation GO:1903538
Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
1 Q5U3G0 (/IDA)
Negative regulation of synapse organization GO:1905809
Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization.
1 P70580 (/IGI)

There are 35 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
10 Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q12091 (/IDA) Q6FUH0 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 O00264 (/HDA) O00264 (/HDA) O00264 (/HDA) O00264 (/HDA) O15173 (/HDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
4 Q4WXS1 (/IDA) Q4WXS1 (/IDA) Q4WXS1 (/IDA) Q4WXS1 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
4 O00264 (/TAS) O00264 (/TAS) O00264 (/TAS) O00264 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 O00264 (/TAS) O00264 (/TAS) O00264 (/TAS) O00264 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 O00264 (/TAS) O00264 (/TAS) O00264 (/TAS) O00264 (/TAS)
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
4 O00264 (/TAS) O00264 (/TAS) O00264 (/TAS) O00264 (/TAS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
4 O00264 (/ISS) O00264 (/ISS) O00264 (/ISS) O00264 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
4 O00264 (/ISS) O00264 (/ISS) O00264 (/ISS) O00264 (/ISS)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
4 O00264 (/ISS) O00264 (/ISS) O00264 (/ISS) O00264 (/ISS)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
4 O00264 (/ISS) O00264 (/ISS) O00264 (/ISS) O00264 (/ISS)
Chromosome, centromeric region GO:0000775
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
2 G5E5M5 (/IDA) Q17QC0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9SK39 (/IDA) Q9SK39 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 G5E5M5 (/ISS) Q17QC0 (/ISS)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
2 G5E5M5 (/IDA) Q17QC0 (/IDA)
Germinal vesicle GO:0042585
The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity.
2 G5E5M5 (/IDA) Q17QC0 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 O55022 (/ISO) O55022 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 O55022 (/ISO) O55022 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
2 O55022 (/ISO) O55022 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
2 O55022 (/ISO) O55022 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 G5E5M5 (/ISS) Q17QC0 (/ISS)
Meiotic spindle midzone GO:1990385
The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap.
2 G5E5M5 (/IDA) Q17QC0 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q5SSH8 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 O15173 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q80UU9 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 O13995 (/HDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 O13995 (/IC)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9VXM4 (/IDA)
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
1 Q9VXM4 (/HDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 P70580 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O15173 (/TAS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P70580 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P70580 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 P70580 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 P70580 (/IDA)
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