The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: recombining binding protein suppressor of hairless

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 35 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
7 O08674 (/IDA) O08674 (/IDA) P28159 (/IDA) P28159 (/IDA) P31266 (/IDA) Q06330 (/IDA) Q06330 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P28159 (/IPI) P28159 (/IPI) P31266 (/IPI) Q06330 (/IPI) Q06330 (/IPI) Q91880 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
6 Q3SZ41 (/ISS) Q3SZ41 (/ISS) Q3SZ41 (/ISS) Q5RFK6 (/ISS) Q5RFK6 (/ISS) Q91880 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
5 O08674 (/IDA) O08674 (/IDA) P28159 (/IDA) P28159 (/IDA) P31266 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
5 Q3SZ41 (/ISS) Q3SZ41 (/ISS) Q3SZ41 (/ISS) Q5RFK6 (/ISS) Q5RFK6 (/ISS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
5 G5EDU7 (/IDA) P31266 (/IDA) Q06330 (/IDA) Q06330 (/IDA) Q8MXE7 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
4 O08674 (/IDA) O08674 (/IDA) P28159 (/IDA) P28159 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
3 P31266 (/IDA) Q06330 (/IDA) Q06330 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 Q06330 (/ISA) Q06330 (/ISA) Q9UBG7 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 Q06330 (/ISM) Q06330 (/ISM) Q9UBG7 (/ISM)
Showing 1 to 10 of 35 entries

There are 160 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
7 A4FTT3 (/IMP) P28159 (/IMP) P28159 (/IMP) P31266 (/IMP) Q06330 (/IMP) Q06330 (/IMP) Q6YLA3 (/IMP)
Positive regulation of transcription of Notch receptor target GO:0007221
The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain.
7 P31266 (/ISS) Q3SZ41 (/ISS) Q3SZ41 (/ISS) Q3SZ41 (/ISS) Q5RFK6 (/ISS) Q5RFK6 (/ISS) Q91880 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
7 G5EDU7 (/IMP) P28159 (/IMP) P28159 (/IMP) P31266 (/IMP) Q06330 (/IMP) Q06330 (/IMP) Q8MXE7 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
7 P31266 (/ISS) Q3SZ41 (/ISS) Q3SZ41 (/ISS) Q3SZ41 (/ISS) Q5RFK6 (/ISS) Q5RFK6 (/ISS) Q91880 (/ISS)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
5 A3QQ82 (/IMP) A4FTT3 (/IMP) A4FTT4 (/IMP) P31266 (/IMP) Q6YLA3 (/IMP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
5 A3QQ82 (/IMP) A4FTT3 (/IMP) A4FTT4 (/IMP) P31266 (/IMP) Q6YLA3 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
5 O08674 (/IDA) O08674 (/IDA) P28159 (/IDA) P28159 (/IDA) P31266 (/IDA)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
4 A3QQ82 (/IGI) A4FTT3 (/IGI) A4FTT4 (/IGI) Q6YLA3 (/IGI)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
4 A3QQ82 (/IGI) A4FTT3 (/IGI) A4FTT4 (/IGI) Q6YLA3 (/IGI)
Determination of left/right asymmetry in lateral mesoderm GO:0003140
The establishment of the lateral mesoderm with respect to the left and right halves.
4 A3QQ82 (/IGI) A4FTT3 (/IGI) A4FTT4 (/IGI) Q6YLA3 (/IGI)
Showing 1 to 10 of 160 entries

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 G5EDU7 (/IDA) M0R7Q3 (/IDA) O08674 (/IDA) O08674 (/IDA) P28159 (/IDA) P28159 (/IDA) P31266 (/IDA) Q06330 (/IDA) Q06330 (/IDA) Q8MXE7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 P31266 (/ISS) Q3SZ41 (/ISS) Q3SZ41 (/ISS) Q3SZ41 (/ISS) Q5RFK6 (/ISS) Q5RFK6 (/ISS) Q91880 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P31266 (/ISS) Q3SZ41 (/ISS) Q3SZ41 (/ISS) Q3SZ41 (/ISS) Q5RFK6 (/ISS) Q5RFK6 (/ISS) Q91880 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P28159 (/IDA) P28159 (/IDA) Q06330 (/IDA) Q06330 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O08674 (/IC) O08674 (/IC) P31266 (/IC)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 P31266 (/TAS) Q06330 (/TAS) Q06330 (/TAS)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
3 O08674 (/IDA) O08674 (/IDA) P31266 (/IDA)
MAML1-RBP-Jkappa- ICN1 complex GO:0002193
A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
2 Q06330 (/IDA) Q06330 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q06330 (/IDA) Q06330 (/IDA)
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
2 P28159 (/IDA) P28159 (/IDA)
Showing 1 to 10 of 28 entries
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