CATH Superfamily 2.70.170.10
Neurotransmitter-gated ion-channel ligand-binding domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Neurotransmitter-gated ion-channel ligand-binding domain
".
FunFam 10: neuronal acetylcholine receptor subunit alpha-9
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | A0A0J9YUW0 (/IPI) G3X8Z7 (/IPI) Q9UGM1 (/IPI) |
|
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
|
2 | P43144 (/IDA) Q9UGM1 (/IDA) |
|
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
|
2 | A0A0J9YUW0 (/IMP) G3X8Z7 (/IMP) |
|
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
|
2 | A0A0J9YUW0 (/ISO) G3X8Z7 (/ISO) |
|
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
2 | A0A0J9YUW0 (/ISO) G3X8Z7 (/ISO) |
|
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
1 | P43144 (/EXP) |
|
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
1 | P43144 (/IDA) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cation transport GO:0006812
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | A0A0J9YUW0 (/IMP) G3X8Z7 (/IMP) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
2 | A0A0J9YUW0 (/ISO) G3X8Z7 (/ISO) |
|
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
|
2 | A0A0J9YUW0 (/IMP) G3X8Z7 (/IMP) |
|
Detection of mechanical stimulus involved in sensory perception of sound GO:0050910
The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.
|
2 | A0A0J9YUW0 (/IMP) G3X8Z7 (/IMP) |
|
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | A0A0J9YUW0 (/ISO) G3X8Z7 (/ISO) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | Q9UGM1 (/IGI) |
|
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
|
1 | P43144 (/IEP) |
|
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | P43144 (/IMP) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | A0A0J9YUW0 (/ISO) G3X8Z7 (/ISO) |
|
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
|
2 | P43144 (/IDA) Q9UGM1 (/IDA) |
|
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
|
2 | A0A0J9YUW0 (/ISO) G3X8Z7 (/ISO) |
|
Cholinergic synapse GO:0098981
A synapse that uses acetylcholine as a neurotransmitter.
|
2 | A0A0J9YUW0 (/ISO) G3X8Z7 (/ISO) |
|
Integral component of postsynaptic specialization membrane GO:0099060
The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | A0A0J9YUW0 (/ISO) G3X8Z7 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9UGM1 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q9UGM1 (/IDA) |
|
Cholinergic synapse GO:0098981
A synapse that uses acetylcholine as a neurotransmitter.
|
1 | P43144 (/EXP) |
|
Cholinergic synapse GO:0098981
A synapse that uses acetylcholine as a neurotransmitter.
|
1 | P43144 (/IDA) |
|
Integral component of postsynaptic specialization membrane GO:0099060
The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P43144 (/IDA) |
