The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cupredoxins - blue copper proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: ephrin-A1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P20827 (/IPI) P20827 (/IPI) P20827 (/IPI) P20827 (/IPI) P52793 (/IPI)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
5 P20827 (/TAS) P20827 (/TAS) P20827 (/TAS) P20827 (/TAS) P97553 (/TAS)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
4 P20827 (/TAS) P20827 (/TAS) P20827 (/TAS) P20827 (/TAS)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
4 P20827 (/IPI) P20827 (/IPI) P20827 (/IPI) P20827 (/IPI)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
1 P52793 (/ISO)

There are 49 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
8 P20827 (/ISS) P20827 (/ISS) P20827 (/ISS) P20827 (/ISS) P52794 (/ISS) P97553 (/ISS) Q06AS9 (/ISS) Q3ZC64 (/ISS)
Negative regulation of dendritic spine morphogenesis GO:0061002
Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
8 P20827 (/ISS) P20827 (/ISS) P20827 (/ISS) P20827 (/ISS) P52794 (/ISS) P97553 (/ISS) Q06AS9 (/ISS) Q3ZC64 (/ISS)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
5 P20827 (/IDA) P20827 (/IDA) P20827 (/IDA) P20827 (/IDA) P52793 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
4 P20827 (/ISS) P20827 (/ISS) P20827 (/ISS) P20827 (/ISS)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
4 P20827 (/IGI) P20827 (/IGI) P20827 (/IGI) P20827 (/IGI)
Aortic valve morphogenesis GO:0003180
The process in which the structure of the aortic valve is generated and organized.
4 P20827 (/ISS) P20827 (/ISS) P20827 (/ISS) P20827 (/ISS)
Mitral valve morphogenesis GO:0003183
The process in which the structure of the mitral valve is generated and organized.
4 P20827 (/ISS) P20827 (/ISS) P20827 (/ISS) P20827 (/ISS)
Endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199
A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
4 P20827 (/ISS) P20827 (/ISS) P20827 (/ISS) P20827 (/ISS)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
4 P20827 (/TAS) P20827 (/TAS) P20827 (/TAS) P20827 (/TAS)
Negative regulation of epithelial to mesenchymal transition GO:0010719
Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
4 P20827 (/ISS) P20827 (/ISS) P20827 (/ISS) P20827 (/ISS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
4 P20827 (/IDA) P20827 (/IDA) P20827 (/IDA) P20827 (/IDA)
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
4 P20827 (/IDA) P20827 (/IDA) P20827 (/IDA) P20827 (/IDA)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
4 P20827 (/IDA) P20827 (/IDA) P20827 (/IDA) P20827 (/IDA)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
4 P20827 (/IGI) P20827 (/IGI) P20827 (/IGI) P20827 (/IGI)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
4 P52794 (/ISS) P97553 (/ISS) Q06AS9 (/ISS) Q3ZC64 (/ISS)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
4 P20827 (/TAS) P20827 (/TAS) P20827 (/TAS) P20827 (/TAS)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
4 P20827 (/IDA) P20827 (/IDA) P20827 (/IDA) P20827 (/IDA)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
4 P20827 (/IGI) P20827 (/IGI) P20827 (/IGI) P20827 (/IGI)
Positive regulation of protein tyrosine kinase activity GO:0061098
Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
4 P20827 (/IGI) P20827 (/IGI) P20827 (/IGI) P20827 (/IGI)
Positive regulation of amyloid-beta formation GO:1902004
Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.
4 P20827 (/IDA) P20827 (/IDA) P20827 (/IDA) P20827 (/IDA)
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961
Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
4 P20827 (/IGI) P20827 (/IGI) P20827 (/IGI) P20827 (/IGI)
Negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051
Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.
4 P20827 (/IGI) P20827 (/IGI) P20827 (/IGI) P20827 (/IGI)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P52793 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 P97553 (/NAS)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 P52793 (/ISO)
Aortic valve morphogenesis GO:0003180
The process in which the structure of the aortic valve is generated and organized.
1 P52793 (/IMP)
Mitral valve morphogenesis GO:0003183
The process in which the structure of the mitral valve is generated and organized.
1 P52793 (/IMP)
Endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199
A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
1 P52793 (/IMP)
Negative regulation of epithelial to mesenchymal transition GO:0010719
Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 P52793 (/IMP)
Notochord formation GO:0014028
The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.
1 P52793 (/IGI)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 P52793 (/ISO)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 P52793 (/IDA)
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
1 P52793 (/ISO)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
1 P52793 (/ISO)
Negative regulation of MAPK cascade GO:0043409
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
1 P52793 (/IDA)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 P52793 (/IDA)
Regulation of blood vessel endothelial cell migration GO:0043535
Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
1 P52793 (/IDA)
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
1 P52793 (/IDA)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
1 P52793 (/ISO)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 P52793 (/IDA)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 P52793 (/ISO)
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
1 P52793 (/IDA)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
1 P52793 (/ISO)
Negative regulation of dendritic spine morphogenesis GO:0061002
Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 P52793 (/IDA)
Positive regulation of protein tyrosine kinase activity GO:0061098
Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
1 P52793 (/ISO)
Negative regulation of thymocyte apoptotic process GO:0070244
Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptotic process.
1 P52793 (/IDA)
Positive regulation of amyloid-beta formation GO:1902004
Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.
1 P52793 (/ISO)
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961
Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
1 P52793 (/ISO)
Negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051
Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.
1 P52793 (/ISO)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P20827 (/NAS) P20827 (/NAS) P20827 (/NAS) P20827 (/NAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P20827 (/TAS) P20827 (/TAS) P20827 (/TAS) P20827 (/TAS)
Anchored component of plasma membrane GO:0046658
The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
1 P52793 (/IDA)
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