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CATH Superfamily 2.60.40.1930

Macroglobulin (MG2) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Macroglobulin (MG2) domain

This entry represents the MG2 (macroglobulin) domain of alpha-2-macroglobulin PMID:16177781. A2M-like proteins have been identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4 PMID:25221932,PMID:22290936. They consist of one three-stranded and one four-stranded anti-parallel beta-sheet stacked in an approximately parallel sandwich arrangement PMID:17608619.

PMID:16177781 PMID:25221932 PMID:22290936 PMID:17608619

GO Diversity

Unique GO annotations
154 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
4246 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 181
Domain clusters (>95% seq id): 19
Domain clusters (>35% seq id): 13
Unique PDBs: 38
Alignments
Structural Clusters (5A): 2
Structural Clusters (9A): 2
FunFam Clusters: 38
Function
Unique EC:
Unique GO: 154
Taxonomy
Unique Species: 4246
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