The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"ntegrin, alpha v. Chain A, domain 3
".
FunFam 1: Integrin alpha V
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 34 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
13 |
A0A0G2JVZ6 (/IPI)
B3DIZ6 (/IPI)
B3DJQ3 (/IPI)
B8JLK8 (/IPI)
F1LZX9 (/IPI)
P06756 (/IPI)
P06756 (/IPI)
P08514 (/IPI)
P08648 (/IPI)
P11688 (/IPI)
(3 more) |
|
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
5 | A0A0G2K1E2 (/IPI) P06756 (/IPI) P06756 (/IPI) P11688 (/IPI) P43406 (/IPI) |
|
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
|
3 | G3HHR9 (/IDA) P06756 (/IDA) P06756 (/IDA) |
|
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
|
3 | B3DJJ0 (/IGI) Q5I2A9 (/IGI) Q6QAF3 (/IGI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
3 | B3DJJ0 (/IPI) Q5I2A9 (/IPI) Q6QAF3 (/IPI) |
|
Transforming growth factor beta binding GO:0050431
Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types.
|
3 | P06756 (/ISS) P06756 (/ISS) P43406 (/ISS) |
|
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
|
2 | P06756 (/IDA) P06756 (/IDA) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | A0A0G2JVZ6 (/IPI) F1LZX9 (/IPI) |
|
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
2 | P11688 (/ISO) P43406 (/ISO) |
|
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
2 | P06756 (/IDA) P06756 (/IDA) |
Showing 1 to 10 of 34 entries
There are 173 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Axis elongation involved in somitogenesis GO:0090245
The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis.
|
7 | B3DJJ0 (/IMP) B3DJQ3 (/IMP) B8JLK8 (/IMP) Q3LTM3 (/IMP) Q5I2A9 (/IMP) Q5RLN6 (/IMP) Q6QAF3 (/IMP) |
|
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
|
6 | P11688 (/ISS) P26008 (/ISS) P43406 (/ISS) P80746 (/ISS) Q06274 (/ISS) Q27977 (/ISS) |
|
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
|
6 | A0A023GU64 (/IMP) A0A023GU65 (/IMP) B3DJJ0 (/IMP) E7F7L7 (/IMP) Q5I2A9 (/IMP) Q6QAF3 (/IMP) |
|
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
|
5 | B3DJQ3 (/IMP) B8JLK8 (/IMP) P43406 (/IMP) Q3LTM3 (/IMP) Q5RLN6 (/IMP) |
|
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
|
5 | P06756 (/TAS) P06756 (/TAS) P08514 (/TAS) P08648 (/TAS) P53708 (/TAS) |
|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
4 | A0A0G2JVZ6 (/IEP) F1LZX9 (/IEP) P06756 (/IEP) P06756 (/IEP) |
|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
4 | B3DJQ3 (/IGI) B8JLK8 (/IGI) Q3LTM3 (/IGI) Q5RLN6 (/IGI) |
|
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
|
4 | B3DJQ3 (/IGI) B8JLK8 (/IGI) Q3LTM3 (/IGI) Q5RLN6 (/IGI) |
|
Endothelial cell proliferation GO:0001935
The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
|
4 | B3DJQ3 (/IGI) B8JLK8 (/IGI) Q3LTM3 (/IGI) Q5RLN6 (/IGI) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
4 | A0A0G2K1E2 (/IDA) P06756 (/IDA) P06756 (/IDA) P08648 (/IDA) |
Showing 1 to 10 of 173 entries
There are 77 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
10 | A2RQD8 (/IDA) A2RQD8 (/IDA) D3ZAC0 (/IDA) D3ZXC1 (/IDA) P06756 (/IDA) P06756 (/IDA) P08648 (/IDA) P11688 (/IDA) P53708 (/IDA) Q9QUM0 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
9 | A2ARA8 (/TAS) F1LZX9 (/TAS) P06756 (/TAS) P06756 (/TAS) P08514 (/TAS) P08648 (/TAS) P26008 (/TAS) P43406 (/TAS) P53708 (/TAS) |
|
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
|
9 | A0A0G2K1E2 (/IDA) B3DIZ6 (/IDA) B3DJQ3 (/IDA) B8JLK8 (/IDA) P06756 (/IDA) P06756 (/IDA) Q3LTM3 (/IDA) Q5RLN6 (/IDA) Q6EIY7 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
6 | L7RXH0 (/IDA) L7RXH0 (/IDA) P06756 (/IDA) P06756 (/IDA) P08648 (/IDA) Q9QUM0 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
6 | P11688 (/ISS) P26008 (/ISS) P43406 (/ISS) P80746 (/ISS) Q06274 (/ISS) Q27977 (/ISS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
6 | P06756 (/ISS) P06756 (/ISS) P11688 (/ISS) P43406 (/ISS) Q06274 (/ISS) Q27977 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | P06756 (/IDA) P06756 (/IDA) P08648 (/IDA) P11688 (/IDA) P43406 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | L7RXH0 (/IDA) L7RXH0 (/IDA) P06756 (/IDA) P06756 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
4 | P06756 (/HDA) P06756 (/HDA) P08648 (/HDA) P53708 (/HDA) |
|
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
|
4 | A2RQD8 (/NAS) A2RQD8 (/NAS) P06756 (/NAS) P06756 (/NAS) |
Showing 1 to 10 of 77 entries
