×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
C2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1463
3D
2q3xB00 - 88.5
2
1177
3D
6nytA00 - 93.4
3
986
3D
1v27A00 - 92.7
4
853
3D
4kitB06 - 96.1
5
836
3D
3hn8C02 - 85.7
7
835
3D
5vfgA00 - 89.5
6
830
3D
3fdwB00 - 98.4
8
809
3D
4qj5B04 - 95.1
9
784 - - 86.4
10
759 - - 81.1
12
739
3D
4dnlA00 - 84.0
11
739
3D
3hn8C01 - 92.7
13
698 - - 85.4
14
624 - - 93.5
16
598
3D
5vfeB00 - 90.4
15
590 - - 75.4
17
517 - - 79.0
18
514 - - 90.3
19
492
3D
2ep6A01 - 87.2
20
485 - - 28.6
21
454 - - 70.9
22
444 - - 80.3
23
442
3D
2k3hA00 - 84.8
24
416
3D
3pycA00 - 85.1
25
415
3D
4p42A02 - 93.6
26
393 - - 87.9
27
393
3D
2d8kA00 - 73.3
28
389
3D
3n5aA00 - 84.3
29
381
3D
3jzyA00 - 78.2
30
371
3D
1rlwA00 - 94.9
31
360
3D
2cjtD00 - 79.9
32
359
3D
5lowJ00 - 89.5
33
333 - - 70.6
34
332 - - 90.0
36
325
3D
6bu0C00 - 84.8
35
325 - - 67.1
37
309 - - 74.6
38
308 - - 71.7
41
303
3D
4yknA05 - 85.1
39
302
3D
1w16A00 - 94.4
40
298 - - 84.2
46
288
3D
5dxuA02 - 92.9
43
275 - - 81.0
42
275 - - 94.2
44
265
3D
3l4cB00 - 78.7
45
260 - - 91.3
47
257
3D
2nsqA00 - 76.0
48
256
3D
4kitB12 - 86.8
49
249
3D
1yrkA00 - 90.7
50
245 - - 92.6
51
242
3D
1ugkA00 - 87.1
52
237 - - 54.4
87
236
3D
6c1sA02 - 91.9
53
215
3D
2enpA00 - 85.3
54
209 - - 82.9
61
207
3D
4iqhC00 - 55.7
56
206
3D
2fk9A00 - 89.2
59
205
3D
2qz5B00 - 93.3
55
205 - - 88.0
57
203 - - 53.1
58
202 - - 91.7
60
200 - - 86.3
62
198 - - 87.5
64
190 - - 82.2
63
190 - - 72.0
65
189 - - 96.7
66
189 - - 89.3
68
188 - - 76.4
67
188 - - 84.4
69
182 - - 83.8
70
181 - - 87.3
71
171 - - 71.8
73
170
3D
2yrbA01 - 84.3
72
169 - - 62.2
74
166 - - 73.9
75
163 - - 74.5
76
161 - - 83.8
78
160
3D
2dmgA00 - 74.1
77
160 - - 74.8
84
156
3D
6fjdB00 - 82.5
79
154 - - 75.2
80
151 - - 79.1
82
150 - - 77.3
81
150 - - 50.6
83
148 - - 83.8
85
146 - - 86.2
98
144
3D
2isdB04 - 75.6
86
144 - - 64.6
91
139
3D
4p42A03 - 79.2
89
137 - - 52.3
88
137 - - 84.2
90
135 - - 88.5
92
134
3D
2nq3A00 - 79.7
93
130 - - 95.3
95
129
3D
6eelC00 - 43.2
94
125 - - 74.6
96
124 - - 76.3
99
122 - - 88.1
97
122 - - 56.8
100
121 - - 98.6
101
119 - - 95.1
102
118 - - 92.4
103
116 - - 76.9
105
115
3D
2zkmX04 - 78.1
104
114 - - 72.8
106
113 - - 90.2
107
109 - - 77.4
111
106
3D
5h4zB00 - 78.4
108
106 - - 90.0
112
106
3D
6fljA00 - 58.9
109
105 - - 39.1
110
103 - - 52.2
113
101 - - 96.1
114
100 - - 89.1
115
97 - - 12.2
116
96 - - 70.3
118
94
3D
3l9bA00 - 54.0
117
93 - - 29.7
119
92 - - 86.9
120
91 - - 70.1
121
90 - - 71.7
122
89 - - 71.9
123
89 - - 46.1
133
88
3D
5lj5B12 - 98.2
124
86 - - 83.9
125
83 - - 73.1
126
82 - - 34.6
128
82 - - 81.9
127
82 - - 47.0
129
81 - - 74.5
131
81 - - 95.4
130
81 - - 76.0
132
80 - - 67.6
134
76 - - 37.4
137
76
3D
1rh8A00 - 75.4
136
75 - - 71.5
135
75 - - 80.7
138
73 - - 88.6
139
71 - - 75.1
141
65 - - 37.3
140
65 - - 85.6
143
64 - - 59.1
142
64 - - 72.8
144
62 - - 43.1
145
62
3D
1wfmA00 - 77.8
146
60 - - 59.2
147
60 - - 72.3
148
58 - - 54.5
149
58 - - 95.8
151
57 - - 79.9
150
57 - - 67.6
152
55 - - 77.8
154
54 - - 40.4
153
54 - - 66.9
155
54 - - 88.0
156
53 - - 79.8
157
53 - - 36.8
158
53 - - 88.1
159
53 - - 34.8
160
52 - - 71.7
161
52 - - 67.5
162
51 - - 71.0
163
50 - - 73.8
164
50 - - 43.4
165
49 - - 21.6
166
48 - - 74.7
167
46 - - 77.4
168
45 - - 92.3
169
Npl1
42 - - 75.0
170
41 - - 61.8
173
40 - - 90.0
172
40 - - 55.4
171
40 - - 69.4
174
39 - - 93.4
175
38 - - 39.0
177
37 - - 59.0
176
37 - - 92.8
178
36 - - 25.7
179
36 - - 86.8
180
35 - - 75.4
182
35 - - 87.4
181
35 - - 86.3
183
32 - - 93.5
184
31 - - 73.7
185
31 - - 18.5
188
29 - - 79.0
187
29 - - 71.2
186
29 - - 82.1
189
29
3D
4qamB00 - 54.1
192
27 - - 60.8
190
27 - - 56.0
191
27 - - 70.3
193
26 - - 72.7
194
26 - - 75.8
195
26 - - 17.0
216
25
3D
5ug7A00 - 67.1
196
25 - - 70.6
202
24 - - 95.2
197
24 - - 73.6
198
24 - - 75.8
200
24 - - 17.0
201
24 - - 77.3
199
24 - - 85.3
203
CaLB domain
23 - - 21.1
204
22 - - 20.1
205
21 - - 62.9
209
21 - - 92.6
207
21 - - 80.6
210
21 - - 94.8
208
21 - - 85.2
206
21 - - 22.7
218
20 - - 77.6
220
20 - - 76.4
217
20 - - 89.4
222
20 - - 89.9
213
20 - - 45.1
214
20 - - 80.9
221
20 - - 87.3
219
20 - - 95.6
212
20 - - 69.2
215
20 - - 8.5
211
20 - - 78.5
225
19 - - 10.0
223
19 - - 76.0
224
19 - - 4.9
226
19 - - 79.5
229
18 - - 3.0
230
18 - - 74.2
228
18 - - 21.8
227
18 - - 4.1
231
18 - - 92.0
237
17 - - 96.1
233
17 - - 14.0
234
17 - - 19.5
236
17 - - 18.5
232
17 - - 0.0
235
17 - - 24.4
238
16 - - 74.3
240
16 - - 27.5
239
16 - - 32.7
243
15 - - 91.3
244
15 - - 60.5
242
CaLB domain
15 - - 30.3
241
15 - - 83.3
247
14 - - 0.0
248
14 - - 20.2
263
14
3D
3fbkB00 - 90.7
246
14 - - 41.8
245
14 - - 14.6
253
13 - - 12.0
257
13 - - 45.5
258
13 - - 7.3
256
13 - - 83.3
254
13 - - 12.2
255
13 - - 71.4
252
13 - - 51.7
249
13 - - 75.7
250
13 - - 10.3
251
13 - - 2.9
264
12 - - 84.9
261
12 - - 50.6
259
PIK-A
12 - - 18.4
265
12 - - 2.8
262
12 - - 31.4
260
12 - - 63.9
266
11 - - 65.1
365
11
3D
5lj5B06 - 7.1
273
11 - - 97.4
267
11 - - 11.3
268
11 - - 15.1
271
11 - - 4.6
269
11 - - 2.9
272
11 - - 76.6
270
11 - - 5.8
284
10 - - 8.0
276
10 - - 9.8
286
10 - - 20.8
274
10 - - 81.3
277
10 - - 65.5
278
10 - - 4.9
288
10 - - 75.5
283
10 - - 8.9
287
10 - - 66.5
291
10 - - 76.1
281
10 - - 70.3
280
10 - - 9.5
285
10 - - 50.3
279
10 - - 0.0
282
10 - - 14.6
275
10 - - 49.7
289
10 - - 89.0
290
DUF3451
10 - - 41.3
303
9 - - 18.0
296
9 - - 22.4
294
9 - - 78.9
297
9 - - 8.7
293
9 - - 74.7
298
9 - - 2.7
304
9 - - 22.9
302
9 - - 13.9
300
9 - - 69.0
301
9 - - 75.5
299
9 - - 12.8
292
9 - - 44.7
295
9 - - 71.4
307
8 - - 77.1
310
8 - - 11.3
312
8 - - 33.3
308
8 - - 36.4
315
8 - - 13.5
323
8 - - 70.8
319
8 - - 23.7
326
8 - - 83.9
306
8 - - 61.0
324
8 - - 11.8
311
8 - - 1.0
309
8 - - 85.9
318
8 - - 15.2
320
8 - - 15.5
305
8 - - 1.7
317
8 - - 8.1
322
8 - - 38.9
313
8 - - 46.4
325
8 - - 23.5
314
8 - - 70.8
321
8 - - 17.0
316
8 - - 15.6
339
7 - - 6.1
328
7 - - 90.3
327
7 - - 5.7
349
7 - - 95.1
342
7 - - 1.6
345
7 - - 5.7
330
7 - - 12.2
332
7 - - 14.9
335
7 - - 2.2
340
7 - - 10.9
341
7 - - 3.7
331
7 - - 10.3
347
7 - - 35.5
338
7 - - 1.1
329
7 - - 40.4
343
7 - - 4.5
337
7 - - 6.0
348
7 - - 88.5
333
PKN
7 - - 21.2
336
7 - - 3.4
346
7 - - 83.5
334
7 - - 4.1
344
7 - - 11.2
355
6 - - 14.2
352
6 - - 85.0
350
6 - - 33.9
361
6 - - 78.8
359
6 - - 52.8
362
6 - - 16.4
360
6 - - 0.7
351
6 - - 84.7
364
6 - - 16.1
353
6 - - 46.5
357
6 - - 16.8
366
6 - - 5.3
358
6 - - 53.6
354
6 - - 4.9
363
6 - - 43.1
367
6 - - 14.8
356
6 - - 15.0
368
6 - - 48.3
381
5 - - 7.9
391
5 - - 0.0
403
5 - - 42.4
371
5 - - 52.9
392
5 - - 74.1
375
5 - - 72.8
389
5 - - 7.2
395
5 - - 92.5
372
5 - - 20.2
370
5 - - 19.2
404
5 - - 86.4
390
5 - - 12.2
380
5 - - 11.7
385
5 - - 83.2
399
5 - - 68.4
369
5 - - 0.9
382
5 - - 13.4
379
5 - - 17.0
402
5 - - 69.4
386
5 - - 75.2
405
5 - - 68.6
374
5 - - 0.0
400
5 - - 67.3
394
5 - - 94.3
384
5 - - 73.7
376
5 - - 29.4
396
5 - - 12.2
388
5 - - 0.0
383
5 - - 41.5
387
5 - - 9.6
401
5 - - 76.5
397
5 - - 8.1
373
5 - - 17.5
377
5 - - 28.4
393
5 - - 48.1
398
5 - - 21.9
378
5 - - 40.4
419
4 - - 7.8
407
4 - - 7.5
410
4 - - 17.0
408
4 - - 48.9
412
4 - - 26.2
423
4 - - 73.9
415
4 - - 45.4
424
4 - - 64.3
411
4 - - 10.0
406
4 - - 3.0
418
4 - - 13.1
420
4 - - 17.5
417
4 - - 11.4
422
4 - - 10.0
425
4 - - 89.9
413
4 - - 41.9
409
4 - - 70.1
416
4 - - 38.8
414
4 - - 39.2
421
4 - - 12.5
442
3 - - 0.8
430
3 - - 34.4
445
3 - - 3.7
461
3 - - 4.2
432
3 - - 72.9
440
3 - - 71.1
435
3 - - 16.9
459
3 - - 0.8
428
3 - - 0.7
439
3 - - 15.8
455
3 - - 0.0
452
3 - - 12.6
449
3 - - 0.0
427
3 - - 23.5
450
3 - - 10.3
451
3 - - 0.0
469
3 - - 67.3
441
3 - - 41.9
465
3 - - 46.6
426
3 - - 7.9
462
3 - - 8.2
470
3 - - 63.3
431
3 - - 69.8
460
3 - - 4.5
453
3 - - 0.0
457
3 - - 1.0
466
3 - - 29.9
458
3 - - 0.0
429
3 - - 15.2
438
3 - - 37.1
447
3 - - 0.0
443
3 - - 6.1
448
CaLB domain
3 - - 4.2
437
3 - - 34.4
464
3 - - 40.7
433
3 - - 4.5
463
3 - - 46.0
467
3 - - 63.3
434
3 - - 6.9
456
3 - - 0.0
444
3 - - 0.0
468
3 - - 61.2
436
3 - - 4.6
454
3 - - 0.0
446
3 - - 15.0
510
2 - - 14.8
552
2 - - 38.8
491
2 - - 0.0
503
2 - - 1.0
555
2 - - 3.2
471
2 - - 4.8
507
2 - - 3.6
528
2 - - 17.9
539
2 - - 0.0
581
2 - - 36.4
515
2 - - 25.6
523
2 - - 0.0
527
2 - - 39.4
512
2 - - 14.0
550
2 - - 33.6
508
2 - - 7.4
549
2 - - 11.4
561
2 - - 0.0
571
2 - - 0.0
530
2 - - 1.3
545
2 - - 3.0
519
2 - - 25.3
542
2 - - 0.0
591
2 - - 43.3
559
2 - - 5.3
540
2 - - 12.2
535
2 - - 2.5
481
2 - - 12.5
532
2 - - 0.0
589
2 - - 44.9
562
2 - - 0.0
572
2 - - 0.0
526
2 - - 38.2
595
2 - - 46.1
480
2 - - 6.6
565
2 - - 3.7
575
2 - - 7.3
592
2 - - 41.2
541
2 - - 0.0
499
2 - - 0.9
506
2 - - 10.6
590
MKS
2 - - 41.9
485
2 - - 21.7
479
2 - - 15.1
560
2 - - 2.2
482
2 - - 0.0
531
2 - - 3.2
570
2 - - 2.8
475
2 - - 0.8
551
2 - - 39.0
492
2 - - 0.0
524
2 - - 39.8
472
2 - - 0.0
580
2 - - 31.6
495
2 - - 0.8
489
2 - - 44.7
582
2 - - 37.9
569
2 - - 0.8
579
2 - - 30.0
504
2 - - 0.0
585
2 - - 12.6
490
2 - - 5.0
511
2 - - 2.2
484
2 - - 29.7
543
2 - - 9.4
586
2 - - 41.5
547
2 - - 7.4
529
2 - - 0.0
538
2 - - 0.0
476
2 - - 10.6
533
2 - - 10.0
594
2 - - 44.0
537
2 - - 4.0
564
2 - - 0.9
496
2 - - 0.0
509
2 - - 6.3
574
2 - - 0.0
548
2 - - 0.0
505
2 - - 0.0
486
2 - - 14.5
557
2 - - 0.0
520
2 - - 24.5
553
2 - - 43.1
584
2 - - 42.0
518
2 - - 20.5
502
2 - - 11.4
474
2 - - 10.0
558
CaLB domain
2 - - 0.0
513
2 - - 22.5
525
2 - - 43.4
500
2 - - 0.9
494
2 - - 2.3
566
2 - - 5.7
576
2 - - 0.0
522
2 - - 26.8
517
2 - - 24.1
588
2 - - 39.5
473
2 - - 0.0
514
2 - - 21.2
497
2 - - 0.0
536
2 - - 0.0
493
2 - - 10.0
501
2 - - 0.0
477
2 - - 10.0
498
2 - - 0.0
546
2 - - 1.8
587
2 - - 42.6
583
2 - - 40.5
478
2 - - 33.8
554
2 - - 14.2
521
2 - - 25.9
516
2 - - 15.5
577
2 - - 0.0
567
2 - - 0.0
534
2 - - 3.8
593
2 - - 40.5
563
2 - - 0.0
488
2 - - 40.1
573
2 - - 15.4
568
2 - - 0.0
483
2 - - 0.0
578
2 - - 20.5
544
2 - - 0.0
556
2 - - 0.0
487
2 - - 34.4
682
1 - - 0.0
829
1 - - 0.0
669
1 - - 0.0
702
1 - - 0.0
718
1 - - 0.0
604
1 - - 0.0
679
1 - - 0.0
784
1 - - 0.0
753
1 - - 0.0
720
1 - - 0.0
757
1 - - 0.0
685
1 - - 0.0
611
1 - - 0.0
705
1 - - 0.0
699
1 - - 0.0
651
1 - - 0.0
809
1 - - 0.0
722
1 - - 0.0
717
1 - - 0.0
776
1 - - 0.0
624
1 - - 0.0
766
1 - - 0.0
700
1 - - 0.0
796
1 - - 0.0
725
1 - - 0.0
680
1 - - 0.0
713
1 - - 0.0
758
1 - - 0.0
738
1 - - 0.0
729
1 - - 0.0
802
1 - - 0.0
690
1 - - 0.0
606
1 - - 0.0
818
1 - - 0.0
747
1 - - 0.0
786
1 - - 0.0
743
1 - - 0.0
660
1 - - 0.0
820
1 - - 0.0
805
1 - - 0.0
631
1 - - 0.0
670
1 - - 0.0
748
1 - - 0.0
689
1 - - 0.0
774
1 - - 0.0
709
1 - - 0.0
662
1 - - 0.0
822
1 - - 0.0
817
1 - - 0.0
764
1 - - 0.0
626
1 - - 0.0
672
1 - - 0.0
695
1 - - 0.0
737
1 - - 0.0
800
1 - - 0.0
794
1 - - 0.0
733
1 - - 0.0
825
1 - - 0.0
665
1 - - 0.0
813
1 - - 0.0
675
1 - - 0.0
692
1 - - 0.0
641
1 - - 0.0
659
1 - - 0.0
801
1 - - 0.0
773
1 - - 0.0
640
1 - - 0.0
763
1 - - 0.0
797
1 - - 0.0
635
1 - - 0.0
793
1 - - 0.0
734
1 - - 0.0
767
1 - - 0.0
777
1 - - 0.0
716
1 - - 0.0
814
1 - - 0.0
632
1 - - 0.0
798
1 - - 0.0
661
1 - - 0.0
821
1 - - 0.0
671
1 - - 0.0
630
1 - - 0.0
645
1 - - 0.0
756
1 - - 0.0
744
1 - - 0.0
619
1 - - 0.0
778
1 - - 0.0
768
1 - - 0.0
642
1 - - 0.0
691
1 - - 0.0
681
1 - - 0.0
701
1 - - 0.0
615
1 - - 0.0
623
1 - - 0.0
736
1 - - 0.0
650
1 - - 0.0
612
1 - - 0.0
627
1 - - 0.0
714
1 - - 0.0
816
1 - - 0.0
608
1 - - 0.0
788
1 - - 0.0
649
1 - - 0.0
652
1 - - 0.0
610
1 - - 0.0
721
1 - - 0.0
603
1 - - 0.0
754
1 - - 0.0
783
1 - - 0.0
787
1 - - 0.0
655
1 - - 0.0
746
1 - - 0.0
607
1 - - 0.0
628
1 - - 0.0
599
1 - - 0.0
639
1 - - 0.0
791
1 - - 0.0
742
1 - - 0.0
828
1 - - 0.0
668
1 - - 0.0
678
1 - - 0.0
719
1 - - 0.0
807
1 - - 0.0
644
1 - - 0.0
656
1 - - 0.0
745
1 - - 0.0
730
1 - - 0.0
771
1 - - 0.0
803
1 - - 0.0
761
1 - - 0.0
810
1 - - 0.0
698
1 - - 0.0
732
1 - - 0.0
677
1 - - 0.0
616
1 - - 0.0
808
1 - - 0.0
827
1 - - 0.0
812
1 - - 0.0
667
1 - - 0.0
634
1 - - 0.0
693
1 - - 0.0
735
1 - - 0.0
697
1 - - 0.0
823
1 - - 0.0
663
1 - - 0.0
740
1 - - 0.0
815
1 - - 0.0
673
1 - - 0.0
759
1 - - 0.0
739
1 - - 0.0
728
1 - - 0.0
819
1 - - 0.0
707
1 - - 0.0
646
1 - - 0.0
687
1 - - 0.0
755
1 - - 0.0
654
1 - - 0.0
683
1 - - 0.0
703
1 - - 0.0
621
1 - - 0.0
752
1 - - 0.0
710
1 - - 0.0
688
1 - - 0.0
749
1 - - 0.0
708
1 - - 0.0
614
1 - - 0.0
750
1 - - 0.0
727
1 - - 0.0
712
1 - - 0.0
596
1 - - 0.0
636
1 - - 0.0
723
1 - - 0.0
601
1 - - 0.0
715
1 - - 0.0
781
1 - - 0.0
658
1 - - 0.0
613
1 - - 0.0
625
1 - - 0.0
780
1 - - 0.0
600
1 - - 0.0
696
1 - - 0.0
826
1 - - 0.0
724
1 - - 0.0
666
1 - - 0.0
617
1 - - 0.0
622
1 - - 0.0
676
1 - - 0.0
751
1 - - 0.0
799
1 - - 0.0
711
1 - - 0.0
605
1 - - 0.0
620
1 - - 0.0
657
1 - - 0.0
785
1 - - 0.0
684
1 - - 0.0
653
1 - - 0.0
806
1 - - 0.0
704
1 - - 0.0
779
1 - - 0.0
618
1 - - 0.0
769
1 - - 0.0
602
1 - - 0.0
782
1 - - 0.0
741
1 - - 0.0
792
1 - - 0.0
775
1 - - 0.0
765
1 - - 0.0
633
1 - - 0.0
694
1 - - 0.0
637
1 - - 0.0
597
1 - - 0.0
795
1 - - 0.0
664
1 - - 0.0
824
1 - - 0.0
726
1 - - 0.0
772
1 - - 0.0
674
1 - - 0.0
609
1 - - 0.0
762
1 - - 0.0
648
1 - - 0.0
789
1 - - 0.0
770
1 - - 0.0
731
1 - - 0.0
811
1 - - 0.0
760
1 - - 0.0
643
1 - - 0.0
686
1 - - 0.0
647
1 - - 0.0
790
1 - - 0.0
706
1 - - 0.0
804
1 - - 0.0
629
1 - - 0.0
638
1 - - 0.0
598
1 - - 0.0
CATH-Gene3D is a Global Biodata Core Resource Learn more...