The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 899: Tissue factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
14 F6QFD4 (/ISS) F6UIK6 (/ISS) G1PUG2 (/ISS) G1RJV1 (/ISS) G3T9C2 (/ISS) G7MI38 (/ISS) G7NV10 (/ISS) P24055 (/ISS) P30931 (/ISS) P30931 (/ISS)
(4 more)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 P13726 (/IPI) P42533 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 P20352 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P13726 (/IPI)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 P13726 (/IDA)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 P20352 (/ISO)

There are 39 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
14 F6QFD4 (/ISS) F6UIK6 (/ISS) G1PUG2 (/ISS) G1RJV1 (/ISS) G3T9C2 (/ISS) G7MI38 (/ISS) G7NV10 (/ISS) P24055 (/ISS) P30931 (/ISS) P30931 (/ISS)
(4 more)
Activation of plasma proteins involved in acute inflammatory response GO:0002541
Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
14 F6QFD4 (/ISS) F6UIK6 (/ISS) G1PUG2 (/ISS) G1RJV1 (/ISS) G3T9C2 (/ISS) G7MI38 (/ISS) G7NV10 (/ISS) P24055 (/ISS) P30931 (/ISS) P30931 (/ISS)
(4 more)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
14 F6QFD4 (/ISS) F6UIK6 (/ISS) G1PUG2 (/ISS) G1RJV1 (/ISS) G3T9C2 (/ISS) G7MI38 (/ISS) G7NV10 (/ISS) P24055 (/ISS) P30931 (/ISS) P30931 (/ISS)
(4 more)
Positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641
Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
14 F6QFD4 (/ISS) F6UIK6 (/ISS) G1PUG2 (/ISS) G1RJV1 (/ISS) G3T9C2 (/ISS) G7MI38 (/ISS) G7NV10 (/ISS) P24055 (/ISS) P30931 (/ISS) P30931 (/ISS)
(4 more)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
14 F6QFD4 (/ISS) F6UIK6 (/ISS) G1PUG2 (/ISS) G1RJV1 (/ISS) G3T9C2 (/ISS) G7MI38 (/ISS) G7NV10 (/ISS) P24055 (/ISS) P30931 (/ISS) P30931 (/ISS)
(4 more)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
14 F6QFD4 (/ISS) F6UIK6 (/ISS) G1PUG2 (/ISS) G1RJV1 (/ISS) G3T9C2 (/ISS) G7MI38 (/ISS) G7NV10 (/ISS) P24055 (/ISS) P30931 (/ISS) P30931 (/ISS)
(4 more)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 P13726 (/IDA)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 P20352 (/ISO)
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
1 B0UY88 (/IMP)
Activation of plasma proteins involved in acute inflammatory response GO:0002541
Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
1 P13726 (/IDA)
Activation of plasma proteins involved in acute inflammatory response GO:0002541
Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
1 P20352 (/ISO)
Activation of blood coagulation via clotting cascade GO:0002543
Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot.
1 P13726 (/IC)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 P13726 (/IDA)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 P20352 (/ISO)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 P42533 (/IEP)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 P13726 (/IDA)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 P20352 (/ISO)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 P20352 (/TAS)
Blood coagulation, extrinsic pathway GO:0007598
A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X.
1 P13726 (/TAS)
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
1 P42533 (/IEP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 P42533 (/IEP)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P42533 (/IEP)
Positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641
Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
1 P13726 (/IDA)
Positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641
Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
1 P20352 (/ISO)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
1 P42533 (/IDA)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
1 P20352 (/ISO)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
1 P13726 (/IDA)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
1 P20352 (/ISO)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 P13726 (/TAS)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P42533 (/IEP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P42533 (/IEP)
Response to fluid shear stress GO:0034405
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
1 P42533 (/IEP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 P13726 (/IDA)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 P20352 (/ISO)
Positive regulation of positive chemotaxis GO:0050927
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
1 P13726 (/IC)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 P13726 (/IMP)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 P20352 (/ISO)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 P42533 (/IEP)
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
1 P42533 (/IEP)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
14 F6QFD4 (/ISS) F6UIK6 (/ISS) G1PUG2 (/ISS) G1RJV1 (/ISS) G3T9C2 (/ISS) G7MI38 (/ISS) G7NV10 (/ISS) P24055 (/ISS) P30931 (/ISS) P30931 (/ISS)
(4 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
14 F6QFD4 (/ISS) F6UIK6 (/ISS) G1PUG2 (/ISS) G1RJV1 (/ISS) G3T9C2 (/ISS) G7MI38 (/ISS) G7NV10 (/ISS) P24055 (/ISS) P30931 (/ISS) P30931 (/ISS)
(4 more)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
14 F6QFD4 (/ISS) F6UIK6 (/ISS) G1PUG2 (/ISS) G1RJV1 (/ISS) G3T9C2 (/ISS) G7MI38 (/ISS) G7NV10 (/ISS) P24055 (/ISS) P30931 (/ISS) P30931 (/ISS)
(4 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P13726 (/IDA) P42533 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P13726 (/IDA) P42533 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P20352 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P42533 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P20352 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P13726 (/NAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P13726 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P13726 (/HDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P20352 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P13726 (/TAS)
Intrinsic component of external side of plasma membrane GO:0031233
The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor.
1 P13726 (/IC)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
1 P13726 (/IDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
1 P20352 (/ISO)
Serine-type peptidase complex GO:1905286
A protein complex which is capable of serine-type peptidase activity.
1 P13726 (/IPI)
Serine-type peptidase complex GO:1905286
A protein complex which is capable of serine-type peptidase activity.
1 P20352 (/ISO)
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