The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 721: Immunoglobulin lambda variable 5-45

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P13372 (/IPI) P13372 (/IPI) P13372 (/IPI)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
3 P13372 (/IPI) P13372 (/IPI) P13372 (/IPI)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
4 P13372 (/IGI) P13372 (/IGI) P13372 (/IGI) P13373 (/IGI)
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
4 P13372 (/IGI) P13372 (/IGI) P13372 (/IGI) P13373 (/IGI)
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
4 P13372 (/IGI) P13372 (/IGI) P13372 (/IGI) P13373 (/IGI)
Homeostasis of number of cells GO:0048872
Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.
4 P13372 (/IGI) P13372 (/IGI) P13372 (/IGI) P13373 (/IGI)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
4 P12018 (/TAS) Q5NV68 (/TAS) Q5NV82 (/TAS) Q5NV87 (/TAS)
Immunoglobulin production GO:0002377
The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
3 P13372 (/IGI) P13372 (/IGI) P13372 (/IGI)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
3 Q5NV68 (/TAS) Q5NV82 (/TAS) Q5NV87 (/TAS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
3 P13372 (/IPI) P13372 (/IPI) P13372 (/IPI)
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
3 Q5NV68 (/TAS) Q5NV82 (/TAS) Q5NV87 (/TAS)
Complement activation, classical pathway GO:0006958
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
3 Q5NV68 (/TAS) Q5NV82 (/TAS) Q5NV87 (/TAS)
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
3 P13372 (/IDA) P13372 (/IDA) P13372 (/IDA)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
3 P13372 (/IMP) P13372 (/IMP) P13372 (/IMP)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
3 Q5NV68 (/TAS) Q5NV82 (/TAS) Q5NV87 (/TAS)
Fc-epsilon receptor signaling pathway GO:0038095
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
3 Q5NV68 (/TAS) Q5NV82 (/TAS) Q5NV87 (/TAS)
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
3 Q5NV68 (/TAS) Q5NV82 (/TAS) Q5NV87 (/TAS)
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
3 P13372 (/IMP) P13372 (/IMP) P13372 (/IMP)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
3 Q5NV68 (/TAS) Q5NV82 (/TAS) Q5NV87 (/TAS)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
4 P12018 (/TAS) Q5NV68 (/TAS) Q5NV82 (/TAS) Q5NV87 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P13372 (/IPI) P13372 (/IPI) P13372 (/IPI)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
3 P13372 (/IDA) P13372 (/IDA) P13372 (/IDA)
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