The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: roundabout homolog 2 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
21 A0A2R8Q4U8 (/IPI) A0A2R8QRK0 (/IPI) A4JYD3 (/IPI) A4JYH1 (/IPI) A8DZ85 (/IPI) F1QFK4 (/IPI) O44924 (/IPI) O55005 (/IPI) O89026 (/IPI) Q1LY64 (/IPI)
(11 more)
Axon guidance receptor activity GO:0008046
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
4 A0A0G2JZA1 (/IDA) D3ZEC8 (/IDA) O55005 (/IDA) Q9QZI3 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 Q9HCK4 (/IDA) Q9HCK4 (/IDA) Q9HCK4 (/IDA) Q9Y6N7 (/IDA)
Axon guidance receptor activity GO:0008046
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
3 Q9HCK4 (/ISS) Q9HCK4 (/ISS) Q9HCK4 (/ISS)
Axon guidance receptor activity GO:0008046
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
3 Q9HCK4 (/NAS) Q9HCK4 (/NAS) Q9HCK4 (/NAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 Q7TPD3 (/ISS) Q90Z70 (/ISS) Q9QZI3 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 M9PC46 (/IDA) Q9GPP7 (/IDA) Q9VQ08 (/IDA)
Axon guidance receptor activity GO:0008046
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
2 O89026 (/ISO) Q7TPD3 (/ISO)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2 O44924 (/IDA) Q9W213 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q90Z41 (/ISA) Q90Z42 (/ISA)
Showing 1 to 10 of 15 entries

There are 170 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
25 A0A2R8Q4U8 (/IMP) A0A2R8QRK0 (/IMP) A4JYD2 (/IMP) A4JYD3 (/IMP) A4JYH1 (/IMP) A8DZ85 (/IMP) B3DJN8 (/IMP) F1QFK4 (/IMP) F1R2D2 (/IMP) M9PC46 (/IMP)
(15 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
12 A0A2R8QRK0 (/IGI) A4JYD2 (/IGI) A4JYD3 (/IGI) A8DZ85 (/IGI) B3DJN8 (/IGI) F1QFK4 (/IGI) F1R2D2 (/IGI) O89026 (/IGI) Q90Z69 (/IGI) Q98SW3 (/IGI)
(2 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
11 M9PC46 (/TAS) O44924 (/TAS) Q9GPP6 (/TAS) Q9GPP7 (/TAS) Q9HCK4 (/TAS) Q9HCK4 (/TAS) Q9HCK4 (/TAS) Q9VPZ7 (/TAS) Q9VQ08 (/TAS) Q9W213 (/TAS)
(1 more)
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
10 A0A2R8QRK0 (/IMP) A4JYD3 (/IMP) A8DZ85 (/IMP) D3Z4M6 (/IMP) F1QFK4 (/IMP) O44924 (/IMP) Q90Z69 (/IMP) Q98SW3 (/IMP) Q9W213 (/IMP) Q9Z2I4 (/IMP)
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
8 A0A2R8Q4U8 (/IGI) A4JYH1 (/IGI) O44924 (/IGI) O89026 (/IGI) Q1LY64 (/IGI) Q7TPD3 (/IGI) Q90Z70 (/IGI) Q9W213 (/IGI)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
7 M9PC46 (/IMP) O44924 (/IMP) Q9GPP6 (/IMP) Q9GPP7 (/IMP) Q9VPZ7 (/IMP) Q9VQ08 (/IMP) Q9W213 (/IMP)
Commissural neuron axon guidance GO:0071679
The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.
7 A0A2R8QRK0 (/IMP) A4JYD3 (/IMP) A8DZ85 (/IMP) D3Z4M6 (/IMP) F1QFK4 (/IMP) Q90Z69 (/IMP) Q98SW3 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
6 A0A0G2JZA1 (/IEP) D3ZEC8 (/IEP) Q9HCK4 (/IEP) Q9HCK4 (/IEP) Q9HCK4 (/IEP) Q9QZI3 (/IEP)
Determination of ventral identity GO:0048264
The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
6 A0A2R8QRK0 (/IMP) A4JYD3 (/IMP) A8DZ85 (/IMP) F1QFK4 (/IMP) Q90Z69 (/IMP) Q98SW3 (/IMP)
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
6 A0A2R8QRK0 (/IMP) A4JYD3 (/IMP) A8DZ85 (/IMP) F1QFK4 (/IMP) Q90Z69 (/IMP) Q98SW3 (/IMP)
Showing 1 to 10 of 170 entries

There are 30 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 A0A0G2JZA1 (/TAS) D3Z4M6 (/TAS) O44924 (/TAS) O55005 (/TAS) O89026 (/TAS) Q7TPD3 (/TAS) Q96MS0 (/TAS) Q9HCK4 (/TAS) Q9HCK4 (/TAS) Q9HCK4 (/TAS)
(2 more)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
9 M9PC46 (/IDA) O44924 (/IDA) O55005 (/IDA) Q9GPP6 (/IDA) Q9GPP7 (/IDA) Q9VPZ7 (/IDA) Q9VQ08 (/IDA) Q9W213 (/IDA) Q9Z2I4 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
6 A0A2R8QRK0 (/IDA) A4JYD3 (/IDA) A8DZ85 (/IDA) F1QFK4 (/IDA) Q90Z69 (/IDA) Q98SW3 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 A0A087WTM1 (/IDA) O44924 (/IDA) Q9VPZ7 (/IDA) Q9W213 (/IDA) Q9Y6N7 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 Q9HCK4 (/IDA) Q9HCK4 (/IDA) Q9HCK4 (/IDA) Q9Y6N7 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 A0A2R8QSG8 (/ISS) A4JYG5 (/ISS) F1RE66 (/ISS) Q71B05 (/ISS)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
4 A0A2R8QSG8 (/IDA) A4JYG5 (/IDA) F1RE66 (/IDA) Q71B05 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
3 A0A024B7I3 (/IDA) Q90Z41 (/IDA) Q90Z42 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 Q7TPD3 (/ISS) Q90Z70 (/ISS) Q9QZI3 (/ISS)
Axolemma GO:0030673
The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.
3 Q9HCK4 (/ISS) Q9HCK4 (/ISS) Q9HCK4 (/ISS)
Showing 1 to 10 of 30 entries
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