The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 1504: Interleukin 18 receptor accessory protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Interleukin-18 receptor activity GO:0042008
Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
2 | Q9Z2B1 (/ISO) Q9Z2B1 (/ISO) |
|
Interleukin-18 receptor activity GO:0042008
Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
2 | Q9Z2B1 (/ISS) Q9Z2B1 (/ISS) |
|
Interleukin-18 binding GO:0042007
Interacting selectively and non-covalently with interleukin-18.
|
1 | A0A0G2K2K7 (/TAS) |
|
Interleukin-18 receptor activity GO:0042008
Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | O95256 (/IDA) |
There are 22 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
2 | Q9Z2B1 (/IMP) Q9Z2B1 (/IMP) |
|
Interferon-gamma production GO:0032609
The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.
|
2 | Q9Z2B1 (/IMP) Q9Z2B1 (/IMP) |
|
Interleukin-6 production GO:0032635
The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
2 | Q9Z2B1 (/IMP) Q9Z2B1 (/IMP) |
|
Interleukin-18-mediated signaling pathway GO:0035655
A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9Z2B1 (/IMP) Q9Z2B1 (/IMP) |
|
Interleukin-18-mediated signaling pathway GO:0035655
A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9Z2B1 (/ISO) Q9Z2B1 (/ISO) |
|
Interleukin-18-mediated signaling pathway GO:0035655
A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9Z2B1 (/ISS) Q9Z2B1 (/ISS) |
|
T-helper 1 cell cytokine production GO:0035744
Any process that contributes to cytokine production by a T-helper 1 cell.
|
2 | Q9Z2B1 (/IMP) Q9Z2B1 (/IMP) |
|
Neutrophil activation GO:0042119
The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
|
2 | Q9Z2B1 (/IMP) Q9Z2B1 (/IMP) |
|
Positive regulation of natural killer cell mediated cytotoxicity GO:0045954
Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
|
2 | Q9Z2B1 (/IMP) Q9Z2B1 (/IMP) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
2 | Q9Z2B1 (/ISO) Q9Z2B1 (/ISO) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
2 | Q9Z2B1 (/ISS) Q9Z2B1 (/ISS) |
|
Cellular response to interleukin-18 GO:0071351
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus.
|
2 | Q9Z2B1 (/IMP) Q9Z2B1 (/IMP) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | O95256 (/TAS) |
|
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
1 | P31398 (/IMP) |
|
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
1 | O95256 (/TAS) |
|
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
|
1 | P31398 (/IEP) |
|
Interleukin-18-mediated signaling pathway GO:0035655
A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | O95256 (/IDA) |
|
Interleukin-18-mediated signaling pathway GO:0035655
A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | O95256 (/TAS) |
|
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
1 | P31398 (/IMP) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
1 | O95256 (/IDA) |
|
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | A0A0G2K2K7 (/IEP) |
|
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | A0A0G2K2K7 (/IEP) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Interleukin-18 receptor complex GO:0045092
A protein complex that binds interleukin-18; comprises an alpha and a beta subunit.
|
2 | Q9Z2B1 (/ISO) Q9Z2B1 (/ISO) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P31398 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | O95256 (/TAS) |
|
Interleukin-18 receptor complex GO:0045092
A protein complex that binds interleukin-18; comprises an alpha and a beta subunit.
|
1 | O95256 (/IDA) |
