The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1050: MER proto-oncogene, tyrosine kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
1 P57097 (/NAS)
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
1 Q12866 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q12866 (/IPI)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
2 P57097 (/IMP) Q12866 (/IMP)
Natural killer cell differentiation GO:0001779
The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
1 Q60805 (/IGI)
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
1 Q60805 (/IGI)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P57097 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q60805 (/ISO)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q12866 (/TAS)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 P57097 (/IDA)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 Q60805 (/ISO)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q12866 (/TAS)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
1 Q12866 (/TAS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q60805 (/IGI)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
1 Q60805 (/IMP)
Secretion by cell GO:0032940
The controlled release of a substance by a cell.
1 Q60805 (/IMP)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
1 Q60805 (/IMP)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
1 Q60805 (/IGI)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
1 Q60805 (/IMP)
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
1 Q60805 (/IGI)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
1 Q12866 (/IDA)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
1 Q60805 (/ISO)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
1 Q12866 (/TAS)
Negative regulation of lymphocyte activation GO:0051250
Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation.
1 Q60805 (/IGI)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
1 Q60805 (/IMP)
Vagina development GO:0060068
The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure.
1 Q60805 (/IGI)
Neutrophil clearance GO:0097350
The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms.
1 Q60805 (/IGI)
Negative regulation of leukocyte apoptotic process GO:2000107
Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process.
1 Q12866 (/IMP)
Negative regulation of leukocyte apoptotic process GO:2000107
Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process.
1 Q60805 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
1 P57097 (/IDA)
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
1 Q60805 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q12866 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q60805 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q12866 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q60805 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q12866 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q12866 (/TAS)
Rhabdomere GO:0016028
The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
1 Q12866 (/IDA)
Rhabdomere GO:0016028
The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
1 Q60805 (/ISO)
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