The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Alpha-ketoglutarate-dependent dioxygenase AlkB-like
".
FunFam 6: AlkB homolog 1, histone H2A dioxygenase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 22 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Oxidative DNA demethylase activity GO:0035516
Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
2 | P0CB42 (/IDA) Q13686 (/IDA) |
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
1 | Q13686 (/IDA) |
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
1 | P0CB42 (/ISO) |
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
1 | P0CB42 (/ISS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P0CB42 (/IPI) |
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
|
1 | Q13686 (/IDA) |
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
|
1 | P0CB42 (/ISO) |
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
|
1 | P0CB42 (/ISS) |
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
|
1 | Q13686 (/IDA) |
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
|
1 | P0CB42 (/ISO) |
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
|
1 | P0CB42 (/ISS) |
Oxidative DNA demethylase activity GO:0035516
Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
1 | P0CB42 (/ISO) |
Chemoattractant activity GO:0042056
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.
|
1 | P0CB42 (/IDA) |
Methylcytosine dioxygenase activity GO:0070579
Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2.
|
1 | Q13686 (/IDA) |
Methylcytosine dioxygenase activity GO:0070579
Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2.
|
1 | P0CB42 (/ISO) |
Methylcytosine dioxygenase activity GO:0070579
Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2.
|
1 | P0CB42 (/ISS) |
Class I DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0140078
Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
|
1 | Q13686 (/IDA) |
Class I DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0140078
Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
|
1 | P0CB42 (/ISO) |
Class I DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0140078
Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
|
1 | P0CB42 (/ISS) |
TRNA demethylase activity GO:1990984
Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule.
|
1 | Q13686 (/IDA) |
TRNA demethylase activity GO:1990984
Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule.
|
1 | P0CB42 (/ISO) |
TRNA demethylase activity GO:1990984
Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule.
|
1 | P0CB42 (/ISS) |
There are 38 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA demethylation GO:0080111
The removal of a methyl group from one or more nucleotides within an DNA molecule.
|
2 | P0CB42 (/IDA) Q13686 (/IDA) |
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
|
1 | P0CB42 (/IMP) |
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
1 | P0CB42 (/IDA) |
Placenta development GO:0001890
The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
|
1 | P0CB42 (/IMP) |
TRNA wobble cytosine modification GO:0002101
The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified.
|
1 | Q13686 (/IDA) |
TRNA wobble cytosine modification GO:0002101
The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified.
|
1 | P0CB42 (/ISO) |
TRNA wobble cytosine modification GO:0002101
The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified.
|
1 | P0CB42 (/ISS) |
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
1 | Q13686 (/IDA) |
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
1 | P0CB42 (/ISO) |
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
1 | P0CB42 (/ISS) |
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
|
1 | Q13686 (/IDA) |
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
|
1 | P0CB42 (/ISO) |
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
|
1 | P0CB42 (/ISS) |
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
|
1 | Q13686 (/TAS) |
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
1 | Q13686 (/IMP) |
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
1 | P0CB42 (/ISO) |
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
1 | P0CB42 (/ISS) |
Regulation of translational elongation GO:0006448
Any process that modulates the frequency, rate, extent or accuracy of translational elongation.
|
1 | Q13686 (/IMP) |
Regulation of translational elongation GO:0006448
Any process that modulates the frequency, rate, extent or accuracy of translational elongation.
|
1 | P0CB42 (/ISO) |
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P0CB42 (/IMP) |
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
|
1 | P0CB42 (/IMP) |
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | P0CB42 (/IDA) |
RNA repair GO:0042245
Any process that results in the repair of damaged RNA.
|
1 | Q13686 (/IDA) |
RNA repair GO:0042245
Any process that results in the repair of damaged RNA.
|
1 | P0CB42 (/ISO) |
RNA repair GO:0042245
Any process that results in the repair of damaged RNA.
|
1 | P0CB42 (/ISS) |
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
1 | P0CB42 (/IDA) |
Developmental growth GO:0048589
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
|
1 | P0CB42 (/IMP) |
Regulation of mitochondrial translation GO:0070129
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.
|
1 | Q13686 (/IMP) |
Regulation of mitochondrial translation GO:0070129
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.
|
1 | P0CB42 (/ISO) |
Regulation of mitochondrial translation GO:0070129
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.
|
1 | P0CB42 (/ISS) |
Oxidative demethylation GO:0070989
The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate.
|
1 | Q13686 (/IDA) |
Oxidative demethylation GO:0070989
The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate.
|
1 | P0CB42 (/ISO) |
Oxidative demethylation GO:0070989
The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate.
|
1 | P0CB42 (/ISS) |
DNA demethylation GO:0080111
The removal of a methyl group from one or more nucleotides within an DNA molecule.
|
1 | P0CB42 (/ISO) |
DNA demethylation GO:0080111
The removal of a methyl group from one or more nucleotides within an DNA molecule.
|
1 | P0CB42 (/ISS) |
TRNA demethylation GO:1990983
The removal of a methyl group from one or more residues within a tRNA molecule.
|
1 | Q13686 (/IDA) |
TRNA demethylation GO:1990983
The removal of a methyl group from one or more residues within a tRNA molecule.
|
1 | P0CB42 (/IMP) |
TRNA demethylation GO:1990983
The removal of a methyl group from one or more residues within a tRNA molecule.
|
1 | P0CB42 (/ISO) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
|
1 | P0CB42 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q13686 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P0CB42 (/ISO) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P0CB42 (/ISS) |