The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Galactose-binding domain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Netrin 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 A0A0B5JK74 (/IPI) A0A0B5JPZ7 (/IPI) A0A0B5JQ66 (/IPI) B0CM04 (/IPI) O09118 (/IPI) O95631 (/IPI) O95631 (/IPI) O95631 (/IPI) O95631 (/IPI) Q90922 (/IPI)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
1 O09118 (/RCA)

There are 57 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dendrite development GO:0016358
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
9 A0A0B5JK74 (/IGI) A0A0B5JPZ7 (/IGI) A0A0R4IN40 (/IGI) B0CM04 (/IGI) B3DJ84 (/IGI) F1QUK5 (/IGI) O42140 (/IGI) O42203 (/IGI) Q29RD2 (/IGI)
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
9 A0A0B5JK74 (/IGI) A0A0B5JPZ7 (/IGI) A0A0R4IN40 (/IGI) B0CM04 (/IGI) B3DJ84 (/IGI) F1QUK5 (/IGI) O42140 (/IGI) O42203 (/IGI) Q29RD2 (/IGI)
Anterior commissure morphogenesis GO:0021960
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum.
9 A0A0B5JK74 (/IGI) A0A0B5JPZ7 (/IGI) A0A0R4IN40 (/IGI) B0CM04 (/IGI) B3DJ84 (/IGI) F1QUK5 (/IGI) O42140 (/IGI) O42203 (/IGI) Q29RD2 (/IGI)
Anterior commissure morphogenesis GO:0021960
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum.
9 A0A0B5JK74 (/IMP) A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) B0CM04 (/IMP) B3DJ84 (/IMP) F1QUK5 (/IMP) O42140 (/IMP) O42203 (/IMP) Q29RD2 (/IMP)
Regulation of axon extension GO:0030516
Any process that modulates the rate, direction or extent of axon extension.
9 A0A0B5JK74 (/IGI) A0A0B5JPZ7 (/IGI) A0A0R4IN40 (/IGI) B0CM04 (/IGI) B3DJ84 (/IGI) F1QUK5 (/IGI) O42140 (/IGI) O42203 (/IGI) Q29RD2 (/IGI)
Olfactory bulb axon guidance GO:0071678
The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues.
9 A0A0B5JK74 (/IGI) A0A0B5JPZ7 (/IGI) A0A0R4IN40 (/IGI) B0CM04 (/IGI) B3DJ84 (/IGI) F1QUK5 (/IGI) O42140 (/IGI) O42203 (/IGI) Q29RD2 (/IGI)
Olfactory bulb axon guidance GO:0071678
The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues.
9 A0A0B5JK74 (/IMP) A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) B0CM04 (/IMP) B3DJ84 (/IMP) F1QUK5 (/IMP) O42140 (/IMP) O42203 (/IMP) Q29RD2 (/IMP)
Substrate-dependent cell migration, cell extension GO:0006930
The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
7 O09118 (/ISS) O95631 (/ISS) O95631 (/ISS) O95631 (/ISS) O95631 (/ISS) Q2HXW4 (/ISS) Q90922 (/ISS)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
7 O09118 (/ISS) O95631 (/ISS) O95631 (/ISS) O95631 (/ISS) O95631 (/ISS) Q2HXW4 (/ISS) Q90922 (/ISS)
Cdc42 protein signal transduction GO:0032488
A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state.
7 O09118 (/ISS) O95631 (/ISS) O95631 (/ISS) O95631 (/ISS) O95631 (/ISS) Q2HXW4 (/ISS) Q90922 (/ISS)
Positive regulation of cell motility GO:2000147
Any process that activates or increases the frequency, rate or extent of cell motility.
7 O09118 (/ISS) O95631 (/ISS) O95631 (/ISS) O95631 (/ISS) O95631 (/ISS) Q2HXW4 (/ISS) Q90922 (/ISS)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
6 O95631 (/ISS) O95631 (/ISS) O95631 (/ISS) O95631 (/ISS) Q2HXW4 (/ISS) Q90922 (/ISS)
Chemorepulsion of axon GO:0061643
The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.
6 O95631 (/ISS) O95631 (/ISS) O95631 (/ISS) O95631 (/ISS) Q2HXW4 (/ISS) Q924Z9 (/ISS)
Anterior/posterior axon guidance GO:0033564
The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
5 A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) O09118 (/IMP) O42140 (/IMP) Q29RD2 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
4 A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) O42140 (/IMP) Q29RD2 (/IMP)
Branching involved in blood vessel morphogenesis GO:0001569
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
4 A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) O42140 (/IMP) Q29RD2 (/IMP)
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
4 A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) O42140 (/IMP) Q29RD2 (/IMP)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
4 A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) O42140 (/IMP) Q29RD2 (/IMP)
Heart jogging GO:0003146
The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis.
4 A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) O42140 (/IMP) Q29RD2 (/IMP)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
4 A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) O42140 (/IMP) Q29RD2 (/IMP)
Thyroid gland development GO:0030878
The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.
4 A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) O42140 (/IMP) Q29RD2 (/IMP)
Ventral aorta development GO:0035908
The progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once.
4 A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) O42140 (/IMP) Q29RD2 (/IMP)
Neuron fate specification GO:0048665
The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
4 A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) O42140 (/IMP) Q29RD2 (/IMP)
Axon extension involved in axon guidance GO:0048846
The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues.
4 A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) O42140 (/IMP) Q29RD2 (/IMP)
Pharyngeal arch artery morphogenesis GO:0061626
The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery.
4 A0A0B5JPZ7 (/IMP) A0A0R4IN40 (/IMP) O42140 (/IMP) Q29RD2 (/IMP)
Negative regulation of netrin-activated signaling pathway GO:1902842
Any process that stops, prevents or reduces the frequency, rate or extent of netrin-activated signaling pathway.
4 O95631 (/TAS) O95631 (/TAS) O95631 (/TAS) O95631 (/TAS)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
2 O09118 (/IDA) Q924Z9 (/IDA)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 O09118 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q90923 (/IDA)
Substrate-dependent cell migration, cell extension GO:0006930
The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
1 Q924Z9 (/IDA)
Substrate-dependent cell migration, cell extension GO:0006930
The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
1 O09118 (/ISO)
Nuclear migration GO:0007097
The directed movement of the nucleus to a specific location within a cell.
1 O09118 (/IDA)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
1 Q924Z9 (/IDA)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
1 O09118 (/ISO)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
1 O09118 (/IDA)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 O09118 (/IDA)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 O09118 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q924Z9 (/NAS)
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 Q90923 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 O09118 (/IMP)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 O09118 (/IDA)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 O09118 (/IMP)
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
1 O09118 (/IDA)
Mammary gland development GO:0030879
The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.
1 O09118 (/IGI)
Cdc42 protein signal transduction GO:0032488
A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state.
1 Q924Z9 (/IDA)
Cdc42 protein signal transduction GO:0032488
A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state.
1 O09118 (/ISO)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
1 O09118 (/IMP)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
1 O09118 (/ISO)
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 O09118 (/EXP)
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 O09118 (/IDA)
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 O09118 (/IMP)
Mammary gland duct morphogenesis GO:0060603
The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk.
1 O09118 (/IGI)
Chemorepulsion of axon GO:0061643
The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.
1 O09118 (/IDA)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 O09118 (/IGI)
Positive regulation of cell motility GO:2000147
Any process that activates or increases the frequency, rate or extent of cell motility.
1 Q924Z9 (/IDA)
Positive regulation of cell motility GO:2000147
Any process that activates or increases the frequency, rate or extent of cell motility.
1 O09118 (/ISO)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
1 O42203 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
6 O09118 (/TAS) O95631 (/TAS) O95631 (/TAS) O95631 (/TAS) O95631 (/TAS) Q924Z9 (/TAS)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 O09118 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O09118 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 Q924Z9 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 O09118 (/ISO)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
1 O09118 (/HDA)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
1 Q90922 (/IDA)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
1 O09118 (/ISO)
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