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Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
931
3D
3r05B01 - 49.7
3
796
3D
3mw2B00 - 84.3
2
756
3D
3fbyC02 - 92.3
4
727
3D
3r05B05 - 81.8
5
724
3D
3r05B02 - 80.6
6
650
3D
2v5yA01 - 90.8
7
547
3D
3r05B04 - 57.1
8
461 - - 92.8
9
442
3D
1ux6A02 - 70.3
21
435
3D
4lbqD00 - 98.4
10
423 - - 79.5
11
413 - - 92.6
12
376 - - 96.2
13
362 - - 81.3
14
356 - - 72.5
227
315
3D
5f5qB00 - 44.5
23
313
3D
3wv6B02 - 96.8
15
309 - - 92.4
17
304
3D
2e6vE01 - 86.8
16
300 - - 87.9
18
284
3D
5hcfF01 - 95.6
70
280
3D
4ayuE00 - 95.3
19
272 - - 77.9
20
255 - - 74.0
22
223 - - 72.9
24
215 - - 76.2
28
213
3D
4ygeE00 - 87.6
25
206
3D
2vh9B00 - 91.9
27
198
3D
1q56A01 - 95.9
26
186 - - 87.7
29
181 - - 77.2
31
180
3D
3pveB00 - 91.6
30
180 - - 82.6
32
165 - - 83.9
33
162 - - 56.2
34
161 - - 84.7
35
160 - - 73.3
54
159
3D
5vwgA00 - 84.4
37
156
3D
4gwnA02 - 96.4
36
156 - - 73.8
41
150
3D
2oujA00 - 85.0
38
148 - - 90.4
39
147 - - 96.6
40
145 - - 91.6
42
141 - - 77.4
43
139
3D
5l73B00 - 77.4
44
135 - - 69.7
46
134
3D
3b9cD00 - 89.2
78
133
3D
3wv6B01 - 86.9
45
129 - - 82.4
184
129
3D
5tpcA01 - 90.3
48
126 - - 98.2
47
126 - - 61.9
49
XI
125 - - 53.1
52
123
3D
2wjsA02 - 57.4
50
123 - - 83.6
51
123 - - 93.7
65
122
3D
5ik8B01 - 73.3
75
119
3D
5lk5J01 - 78.0
63
118
3D
5ik8B02 - 58.7
53
118 - - 77.7
55
117 - - 96.3
73
116
3D
4hanB02 - 73.6
57
115
3D
2wjsA01 - 66.5
56
115 - - 75.4
58
113 - - 65.7
61
113
3D
2wjsA03 - 70.8
59
113 - - 96.1
60
112 - - 53.0
237
111
3D
4m3cH00 - 87.7
62
110 - - 68.3
64
110 - - 77.3
66
109 - - 71.4
68
XXI
108 - - 89.8
67
108 - - 76.7
124
106
3D
5duxD00 - 94.3
69
105 - - 46.1
71
104 - - 87.6
72
103 - - 85.7
74
100 - - 46.6
76
99 - - 76.9
77
98 - - 94.6
79
96 - - 80.9
80
95 - - 30.5
82
93 - - 82.9
81
93 - - 96.9
83
92 - - 73.4
89
90
3D
5vxzB01 - 76.3
84
90 - - 83.2
85
XXVII
90 - - 95.8
114
4
90
3D
3wdyD00 - 89.6
86
88 - - 95.5
87
86 - - 75.7
88
84 - - 84.2
90
82 - - 71.0
91
82 - - 83.3
92
81 - - 78.0
93
80 - - 82.3
107
80
3D
1lhwA00 - 84.7
94
80 - - 91.7
95
79 - - 77.7
96
78 - - 93.9
98
78
3D
5mc9A01 - 72.4
97
77 - - 82.9
99
76 - - 82.6
101
75
3D
3sh5A00 - 72.4
100
74 - - 32.4
102
73 - - 70.9
105
73
3D
2uurA00 - 85.7
103
73 - - 96.0
104
72 - - 72.5
106
71 - - 68.1
118
71
3D
5vxzB02 - 76.7
108
XXII
70 - - 69.7
109
69 - - 76.5
110
68 - - 78.4
111
68 - - 92.4
112
66 - - 91.1
116
65
3D
5mc9A02 - 72.8
119
65
3D
2jd4B01 - 71.0
115
65 - - 59.1
113
65 - - 88.4
117
64 - - 6.5
122
63 - - 83.3
121
63 - - 6.8
120
63 - - 18.3
145
62
3D
4hl0B01 - 85.6
123
62 - - 90.2
388
61
3D
3wg4B00 - 88.6
125
61 - - 82.0
127
60
3D
2jd4B02 - 79.3
131
58
3D
2d44A01 - 68.2
126
58 - - 91.7
128
56 - - 96.1
129
55 - - 88.6
130
55 - - 96.1
155
55
3D
4hl0B02 - 69.3
132
54 - - 94.3
134
53 - - 94.9
133
53 - - 51.4
135
53 - - 83.3
136
52 - - 88.4
137
50 - - 15.9
140
48 - - 90.8
141
48 - - 87.1
138
48 - - 20.4
139
48 - - 90.1
143
47 - - 84.7
144
47 - - 77.9
142
47 - - 42.9
146
45 - - 21.3
147
45 - - 74.4
148
44 - - 73.0
149
43 - - 82.6
150
42 - - 95.4
176
41
3D
6a66A00 - 56.9
151
41 - - 83.0
152
40 - - 90.9
153
40 - - 38.0
157
39 - - 82.5
156
39 - - 64.5
154
39 - - 38.6
159
38 - - 89.3
158
38 - - 44.2
160
37 - - 87.8
164
37 - - 86.4
163
37 - - 70.5
161
37 - - 82.9
162
37 - - 85.7
165
36 - - 71.2
166
36 - - 37.0
170
35 - - 45.0
171
35 - - 84.1
168
35 - - 22.0
169
35 - - 28.2
167
35 - - 69.7
172
34 - - 89.5
173
34 - - 81.8
175
33 - - 57.9
174
33 - - 34.3
179
31 - - 89.8
177
31 - - 49.4
195
31
3D
4itcA00 - 30.1
178
31 - - 87.0
181
31 - - 72.9
180
31 - - 89.1
182
30 - - 94.2
183
30 - - 85.9
185
29 - - 45.6
188
28 - - 82.4
187
28 - - 53.5
186
28 - - 18.6
189
27 - - 16.7
191
27 - - 40.9
193
27 - - 79.6
190
27 - - 79.0
192
27 - - 55.7
194
26 - - 80.6
198
26 - - 88.6
197
26 - - 13.7
196
26 - - 41.1
201
25 - - 77.6
203
25 - - 33.5
200
25 - - 77.7
199
25 - - 72.2
202
25 - - 93.8
204
24 - - 76.5
205
24 - - 34.3
207
24 - - 72.2
208
24 - - 15.7
206
24 - - 33.5
213
23 - - 94.9
211
23 - - 42.9
214
23 - - 81.6
210
23 - - 88.3
209
23 - - 86.1
212
23 - - 11.0
215
22 - - 93.0
217
22 - - 79.6
216
22 - - 15.3
220
21 - - 46.8
221
21 - - 9.6
219
21 - - 76.9
222
21 - - 87.6
218
21 - - 76.1
225
20 - - 29.4
224
20 - - 87.8
223
20 - - 51.4
226
20 - - 9.2
228
20 - - 36.9
232
19 - - 49.9
230
19 - - 39.0
234
19 - - 83.4
229
19 - - 29.1
231
19 - - 37.0
233
19 - - 4.0
236
18 - - 71.0
235
18 - - 90.7
238
17 - - 84.5
244
17
3D
3vv1B00 - 85.7
301
17
3D
2a71D00 - 9.8
239
16 - - 78.3
242
16 - - 11.3
241
16 - - 38.5
240
16 - - 37.0
243
15 - - 17.9
303
15
3D
2dwrA01 - 52.8
245
15 - - 71.9
268
14
3D
4xogA01 - 3.7
249
14 - - 68.5
285
14
3D
4zxkB00 - 5.7
247
14 - - 9.2
248
14 - - 39.6
246
14 - - 93.4
250
13 - - 61.2
309
13
3D
6ekuA03 - 0.0
255
13 - - 9.2
262
13 - - 77.3
253
Cadherin plus 7TM domain
13 - - 24.6
251
13 - - 69.0
254
13 - - 35.0
256
13 - - 86.3
252
13 - - 75.3
261
13 - - 79.2
259
13 - - 78.2
257
13 - - 56.7
260
13 - - 83.7
362
13
3D
5jozB02 - 80.1
258
13 - - 13.6
271
12 - - 87.8
269
12 - - 8.7
267
12 - - 8.8
316
12
3D
4ateA00 - 76.4
266
12 - - 29.1
298
12
3D
2w68C00 - 5.3
270
12 - - 97.1
264
12 - - 49.6
263
12 - - 73.3
265
Cadherin plus 7TM domain
12 - - 19.7
273
11 - - 32.7
280
11 - - 73.9
274
11 - - 41.7
281
11 - - 11.9
275
11 - - 43.7
279
11 - - 22.0
277
11 - - 7.7
278
11 - - 27.6
272
11 - - 15.8
276
11 - - 72.4
284
10 - - 8.0
283
10 - - 7.6
286
10 - - 14.6
282
10 - - 29.3
290
10 - - 1.1
311
10
3D
4wzfB00 - 19.3
288
10 - - 92.2
289
10 - - 1.6
287
10 - - 75.7
292
9 - - 11.9
296
9 - - 20.6
302
9 - - 81.5
297
9 - - 38.0
299
9 - - 9.8
295
9 - - 8.2
294
9 - - 5.9
291
9 - - 12.7
300
9 - - 21.9
293
9 - - 14.7
308
8 - - 5.9
307
8 - - 73.4
312
8 - - 34.4
306
8 - - 20.0
314
8 - - 85.9
304
8 - - 96.7
313
8 - - 71.7
305
8 - - 14.9
310
8 - - 68.7
318
7 - - 37.2
330
7 - - 40.1
326
7 - - 10.2
317
7 - - 26.4
319
7 - - 8.8
322
7 - - 16.7
329
7 - - 83.8
327
7 - - 9.4
328
7 - - 36.3
320
IX
7 - - 1.1
490
7
3D
1fv3B01 - 1.8
325
7 - - 8.8
315
7 - - 45.8
321
7 - - 7.4
323
7 - - 23.1
324
7 - - 12.5
335
6 - - 5.1
331
6 - - 63.9
333
6 - - 6.9
334
6 - - 21.4
332
6 - - 19.9
336
6 - - 62.8
337
6 - - 8.9
339
6 - - 90.7
338
6 - - 73.6
363
5 - - 75.3
352
5 - - 18.1
356
5 - - 3.2
344
5 - - 13.8
361
5 - - 80.4
343
5 - - 16.3
341
5 - - 6.3
360
5 - - 26.0
345
5 - - 12.4
358
5 - - 32.6
340
5 - - 87.2
357
5 - - 44.4
359
5 - - 38.9
355
5 - - 40.2
348
5 - - 0.0
350
5 - - 18.7
347
5 - - 0.0
349
5 - - 2.6
342
5 - - 10.3
346
5 - - 8.8
354
5 - - 6.4
353
5 - - 0.5
351
5 - - 20.5
378
4 - - 8.4
390
4 - - 4.3
401
4 - - 43.5
364
4 - - 3.7
377
4 - - 11.1
379
4 - - 0.0
382
4 - - 11.2
386
4 - - 36.3
395
4 - - 7.6
387
4 - - 33.5
389
4 - - 11.0
391
4 - - 8.5
376
4 - - 8.3
393
4 - - 25.0
372
4 - - 33.6
365
4 - - 31.2
394
4 - - 9.8
400
4 - - 10.4
374
N-acetyl-beta-glucosaminyl
4 - - 10.0
380
4 - - 2.0
367
4 - - 33.1
369
4 - - 24.9
371
4 - - 22.6
368
4 - - 24.3
396
4 - - 7.5
385
4 - - 8.9
373
4 - - 9.6
392
4 - - 3.2
381
4 - - 3.3
399
4 - - 71.6
397
4 - - 4.6
402
4 - - 17.0
383
4 - - 6.2
375
4 - - 0.7
366
4 - - 36.8
398
4 - - 35.1
370
4 - - 12.6
384
4 - - 2.0
414
3 - - 0.0
404
3 - - 38.6
420
3 - - 0.0
413
3 - - 0.0
425
3 - - 0.7
436
3 - - 14.2
411
3 - - 0.0
403
3 - - 29.0
432
3 - - 7.1
421
3 - - 11.0
415
3 - - 2.9
446
3 - - 79.3
442
3 - - 5.4
439
3 - - 0.0
437
3 - - 1.2
405
3 - - 37.8
423
3 - - 0.0
438
3 - - 0.0
410
3 - - 36.7
424
3 - - 10.0
444
3 - - 63.2
408
3 - - 13.0
430
3 - - 61.8
418
3 - - 15.9
443
3 - - 11.9
407
3 - - 12.4
409
3 - - 10.9
422
3 - - 0.0
419
3 - - 0.6
417
3 - - 0.0
426
3 - - 7.6
435
3 - - 3.3
441
3 - - 11.6
427
3 - - 0.0
429
3 - - 38.8
412
3 - - 1.5
431
3 - - 0.0
445
3 - - 75.6
416
3 - - 0.0
433
3 - - 7.2
406
Synaptic protein
3 - - 20.2
440
3 - - 17.3
428
3 - - 31.6
434
3 - - 6.9
530
2 - - 0.0
561
2 - - 31.7
455
2 - - 11.0
518
2 - - 0.0
544
2 - - 1.1
469
2 - - 0.0
467
2 - - 1.3
556
2 - - 37.0
480
2 - - 8.2
448
2 - - 39.4
474
2 - - 0.0
563
CELSR1
2 - - 30.0
552
2 - - 0.0
508
2 - - 0.7
522
2 - - 2.5
471
2 - - 0.0
450
2 - - 48.2
517
2 - - 0.0
519
2 - - 0.0
535
2 - - 2.2
526
2 - - 0.0
541
2 - - 1.8
543
2 - - 0.0
492
2 - - 0.0
509
2 - - 0.0
507
2 - - 2.3
564
2 - - 26.4
473
2 - - 8.6
449
2 - - 39.7
447
2 - - 39.2
485
2 - - 0.5
496
2 - - 1.9
468
2 - - 6.3
497
2 - - 12.4
499
2 - - 0.0
454
2 - - 20.8
572
2 - - 40.0
502
2 - - 1.3
558
2 - - 34.6
533
2 - - 8.9
506
2 - - 1.2
481
2 - - 1.6
529
2 - - 0.0
527
2 - - 0.0
475
2 - - 0.0
483
2 - - 0.0
512
2 - - 26.7
531
2 - - 5.2
516
2 - - 41.2
545
2 - - 1.5
560
2 - - 34.5
462
2 - - 0.0
453
2 - - 11.2
534
2 - - 11.2
557
2 - - 34.6
559
2 - - 37.7
498
2 - - 0.0
466
2 - - 2.2
484
2 - - 6.6
565
2 - - 15.3
540
2 - - 4.0
451
2 - - 40.1
528
2 - - 6.3
470
2 - - 0.0
567
2 - - 34.6
569
2 - - 38.4
456
Synaptic protein
2 - - 18.8
548
2 - - 0.0
452
2 - - 42.5
463
2 - - 8.2
504
2 - - 0.7
478
2 - - 0.0
520
2 - - 0.0
461
2 - - 0.0
555
2 - - 35.3
514
2 - - 34.7
536
2 - - 3.0
479
2 - - 9.3
525
2 - - 6.8
477
2 - - 10.0
511
2 - - 6.0
464
2 - - 0.7
547
2 - - 8.5
549
2 - - 0.0
568
2 - - 31.1
532
2 - - 0.0
503
2 - - 0.0
495
2 - - 8.4
501
2 - - 0.0
571
2 - - 44.9
486
2 - - 1.1
550
2 - - 34.9
482
2 - - 10.7
513
2 - - 11.2
491
2 - - 0.0
505
2 - - 1.2
523
2 - - 1.1
489
2 - - 7.6
487
2 - - 2.1
460
2 - - 30.9
472
2 - - 0.0
554
2 - - 14.6
521
2 - - 0.0
458
2 - - 16.3
546
2 - - 7.0
515
2 - - 32.0
700
2
3D
1ikqA01 - 0.0
493
2 - - 8.3
542
2 - - 0.0
537
2 - - 3.9
476
2 - - 0.8
539
2 - - 4.2
465
2 - - 0.0
488
2 - - 0.6
500
2 - - 1.3
524
2 - - 4.6
551
2 - - 33.3
570
2 - - 54.5
538
2 - - 9.6
553
2 - - 15.2
562
2 - - 6.3
459
2 - - 10.9
457
2 - - 26.0
510
2 - - 0.7
494
2 - - 7.0
566
2 - - 36.2
641
1 - - 0.0
635
1 - - 0.0
626
1 - - 0.0
811
1 - - 0.0
764
1 - - 0.0
682
1 - - 0.0
617
1 - - 0.0
686
1 - - 0.0
707
1 - - 0.0
709
1 - - 0.0
619
1 - - 0.0
803
1 - - 0.0
622
1 - - 0.0
743
1 - - 0.0
590
1 - - 0.0
779
1 - - 0.0
777
1 - - 0.0
695
1 - - 0.0
741
1 - - 0.0
726
1 - - 0.0
735
1 - - 0.0
801
1 - - 0.0
782
1 - - 0.0
664
1 - - 0.0
609
1 - - 0.0
719
1 - - 0.0
813
Cnx
1 - - 0.0
717
1 - - 0.0
607
1 - - 0.0
786
1 - - 0.0
578
1 - - 0.0
643
1 - - 0.0
722
1 - - 0.0
795
1 - - 0.0
677
1 - - 0.0
679
1 - - 0.0
690
1 - - 0.0
595
1 - - 0.0
778
1 - - 0.0
752
1 - - 0.0
618
1 - - 0.0
708
1 - - 0.0
763
1 - - 0.0
586
1 - - 0.0
820
1 - - 0.0
661
1 - - 0.0
582
1 - - 0.0
804
1 - - 0.0
756
1 - - 0.0
630
1 - - 0.0
744
1 - - 0.0
577
1 - - 0.0
579
1 - - 0.0
790
1 - - 0.0
678
1 - - 0.0
663
1 - - 0.0
652
1 - - 0.0
718
1 - - 0.0
608
1 - - 0.0
761
1 - - 0.0
656
1 - - 0.0
814
1 - - 0.0
730
1 - - 0.0
644
1 - - 0.0
728
1 - - 0.0
694
1 - - 0.0
657
1 - - 0.0
659
1 - - 0.0
634
1 - - 0.0
788
1 - - 0.0
593
1 - - 0.0
740
1 - - 0.0
576
1 - - 0.0
765
1 - - 0.0
800
1 - - 0.0
628
1 - - 0.0
591
1 - - 0.0
794
1 - - 0.0
759
1 - - 0.0
757
1 - - 0.0
688
1 - - 0.0
734
1 - - 0.0
587
1 - - 0.0
640
1 - - 0.0
589
1 - - 0.0
665
1 - - 0.0
810
1 - - 0.0
805
1 - - 0.0
760
1 - - 0.0
676
1 - - 0.0
789
1 - - 0.0
787
1 - - 0.0
606
1 - - 0.0
716
1 - - 0.0
745
1 - - 0.0
731
1 - - 0.0
693
1 - - 0.0
602
1 - - 0.0
712
1 - - 0.0
594
1 - - 0.0
658
1 - - 0.0
633
1 - - 0.0
791
1 - - 0.0
672
1 - - 0.0
727
1 - - 0.0
729
1 - - 0.0
815
1 - - 0.0
821
Putative secreted protein
1 - - 0.0
660
1 - - 0.0
776
1 - - 0.0
706
1 - - 0.0
687
1 - - 0.0
616
1 - - 0.0
645
1 - - 0.0
689
1 - - 0.0
793
1 - - 0.0
588
1 - - 0.0
631
1 - - 0.0
691
1 - - 0.0
702
1 - - 0.0
612
1 - - 0.0
758
1 - - 0.0
733
1 - - 0.0
772
1 - - 0.0
629
1 - - 0.0
627
1 - - 0.0
668
1 - - 0.0
817
1 - - 0.0
632
1 - - 0.0
819
1 - - 0.0
603
1 - - 0.0
713
1 - - 0.0
696
1 - - 0.0
685
1 - - 0.0
647
1 - - 0.0
649
1 - - 0.0
580
1 - - 0.0
673
1 - - 0.0
750
1 - - 0.0
771
1 - - 0.0
574
1 - - 0.0
692
1 - - 0.0
701
1 - - 0.0
611
1 - - 0.0
636
1 - - 0.0
625
1 - - 0.0
809
1 - - 0.0
732
1 - - 0.0
703
1 - - 0.0
613
1 - - 0.0
768
1 - - 0.0
807
1 - - 0.0
796
1 - - 0.0
749
1 - - 0.0
785
1 - - 0.0
747
1 - - 0.0
773
1 - - 0.0
650
CELSR1
1 - - 0.0
671
1 - - 0.0
601
1 - - 0.0
711
1 - - 0.0
792
1 - - 0.0
725
1 - - 0.0
736
1 - - 0.0
620
1 - - 0.0
714
1 - - 0.0
604
1 - - 0.0
592
1 - - 0.0
674
1 - - 0.0
755
1 - - 0.0
573
1 - - 0.0
648
1 - - 0.0
585
1 - - 0.0
680
1 - - 0.0
818
1 - - 0.0
667
1 - - 0.0
669
1 - - 0.0
596
1 - - 0.0
720
1 - - 0.0
614
1 - - 0.0
704
1 - - 0.0
774
1 - - 0.0
655
1 - - 0.0
748
1 - - 0.0
780
1 - - 0.0
769
1 - - 0.0
767
1 - - 0.0
808
1 - - 0.0
575
1 - - 0.0
766
1 - - 0.0
670
1 - - 0.0
583
1 - - 0.0
798
1 - - 0.0
651
1 - - 0.0
624
1 - - 0.0
710
1 - - 0.0
600
1 - - 0.0
762
1 - - 0.0
738
1 - - 0.0
684
1 - - 0.0
753
1 - - 0.0
666
1 - - 0.0
770
1 - - 0.0
599
1 - - 0.0
597
1 - - 0.0
751
1 - - 0.0
698
1 - - 0.0
724
1 - - 0.0
610
1 - - 0.0
638
1 - - 0.0
653
1 - - 0.0
784
1 - - 0.0
662
1 - - 0.0
581
1 - - 0.0
781
1 - - 0.0
584
1 - - 0.0
802
1 - - 0.0
739
1 - - 0.0
737
1 - - 0.0
742
1 - - 0.0
623
1 - - 0.0
746
1 - - 0.0
605
1 - - 0.0
715
1 - - 0.0
721
1 - - 0.0
754
1 - - 0.0
683
1 - - 0.0
806
1 - - 0.0
675
1 - - 0.0
797
1 - - 0.0
799
1 - - 0.0
681
1 - - 0.0
637
1 - - 0.0
812
1 - - 0.0
639
1 - - 0.0
723
1 - - 0.0
642
1 - - 0.0
646
1 - - 0.0
705
1 - - 0.0
615
1 - - 0.0
621
1 - - 0.0
816
1 - - 0.0
598
1 - - 0.0
654
1 - - 0.0
783
1 - - 0.0
699
1 - - 0.0
697
1 - - 0.0
775
1 - - 0.0
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