The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: PZP, alpha-2-macroglobulin like

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 31 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 P01023 (/IPI) Q7SIH1 (/IPI)
Endopeptidase inhibitor activity GO:0004866
Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
2 P06238 (/IDA) Q61838 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P01023 (/IPI) Q6GQT1 (/IPI)
Peptidase inhibitor activity GO:0030414
Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
2 Q03626 (/TAS) Q6GQT1 (/TAS)
Brain-derived neurotrophic factor binding GO:0048403
Interacting selectively and non-covalently with brain-derived neurotrophic factor.
2 P06238 (/IDA) Q63041 (/IDA)
Brain-derived neurotrophic factor binding GO:0048403
Interacting selectively and non-covalently with brain-derived neurotrophic factor.
2 Q61838 (/ISO) Q6GQT1 (/ISO)
Nerve growth factor binding GO:0048406
Interacting selectively and non-covalently with nerve growth factor (NGF).
2 P06238 (/IDA) Q63041 (/IDA)
Nerve growth factor binding GO:0048406
Interacting selectively and non-covalently with nerve growth factor (NGF).
2 Q61838 (/ISO) Q6GQT1 (/ISO)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 Q6GQT1 (/ISO)
Endopeptidase inhibitor activity GO:0004866
Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
1 Q6GQT1 (/ISO)
Endopeptidase inhibitor activity GO:0004866
Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
1 P20742 (/TAS)
Serine-type endopeptidase inhibitor activity GO:0004867
Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
1 P01023 (/IDA)
Serine-type endopeptidase inhibitor activity GO:0004867
Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
1 Q6GQT1 (/ISO)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P01023 (/IMP)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q6GQT1 (/ISO)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
1 P01023 (/IDA)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
1 Q6GQT1 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P01023 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q6GQT1 (/ISO)
Interleukin-8 binding GO:0019959
Interacting selectively and non-covalently with interleukin-8.
1 P01023 (/IPI)
Interleukin-8 binding GO:0019959
Interacting selectively and non-covalently with interleukin-8.
1 Q6GQT1 (/ISO)
Interleukin-1 binding GO:0019966
Interacting selectively and non-covalently with interleukin-1.
1 P01023 (/IDA)
Interleukin-1 binding GO:0019966
Interacting selectively and non-covalently with interleukin-1.
1 Q6GQT1 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P06238 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q6GQT1 (/ISO)
Tumor necrosis factor binding GO:0043120
Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.
1 P01023 (/IDA)
Tumor necrosis factor binding GO:0043120
Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.
1 Q6GQT1 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q63041 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q61838 (/ISO)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 P01023 (/IPI)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 Q6GQT1 (/ISO)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
2 P28665 (/IGI) Q61838 (/IGI)
Luteinization GO:0001553
The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.
1 P06238 (/IEP)
Negative regulation of complement activation, lectin pathway GO:0001869
Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway.
1 P01023 (/IDA)
Negative regulation of complement activation, lectin pathway GO:0001869
Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway.
1 Q6GQT1 (/ISO)
Acute inflammatory response to antigenic stimulus GO:0002438
An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
1 P06238 (/IEP)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
1 P01023 (/TAS)
Acute-phase response GO:0006953
An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
1 P06238 (/IEP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 Q03626 (/IEP)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
1 P20742 (/TAS)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 P06238 (/IEP)
Blood coagulation, intrinsic pathway GO:0007597
A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X.
1 P01023 (/TAS)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 P06238 (/TAS)
Response to carbon dioxide GO:0010037
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus.
1 P06238 (/IEP)
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
1 P06238 (/IDA)
Extracellular matrix disassembly GO:0022617
A process that results in the breakdown of the extracellular matrix.
1 P01023 (/TAS)
Response to prostaglandin E GO:0034695
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
1 P06238 (/IEP)
Stem cell differentiation GO:0048863
The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
1 Q6GQT1 (/IDA)
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
1 P01023 (/TAS)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 P06238 (/IDA)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P06238 (/IEP)
Embryonic liver development GO:1990402
The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure.
1 P06238 (/IEP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P01023 (/NAS) P20742 (/NAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P01023 (/TAS) Q61838 (/TAS)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
2 P01023 (/HDA) Q61838 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P01023 (/HDA) P20742 (/HDA)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
2 P01023 (/HDA) P20742 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P06238 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q6GQT1 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P01023 (/TAS)
Platelet alpha granule lumen GO:0031093
The volume enclosed by the membrane of the platelet alpha granule.
1 P01023 (/TAS)
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