The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 64: Hepatocyte growth factor-like protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 F7FMS0 (/IPI) P70521 (/IPI)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
2 P26928 (/ISS) Q24K22 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P26927 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P26928 (/ISO)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
1 P26927 (/IDA)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
1 P26928 (/ISO)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 F7FMS0 (/IEP) P70521 (/IEP)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
2 F7FMS0 (/IEP) P70521 (/IEP)
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
2 P26928 (/ISS) Q24K22 (/ISS)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 F7FMS0 (/IEP) P70521 (/IEP)
Regulation of cAMP-dependent protein kinase activity GO:2000479
Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity.
2 P26928 (/ISS) Q24K22 (/ISS)
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
1 P26928 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P26928 (/IMP)
Regulation of macrophage chemotaxis GO:0010758
Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
1 P26928 (/IMP)
Mammary gland development GO:0030879
The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.
1 P26928 (/IMP)
Positive regulation of mammary gland epithelial cell proliferation GO:0033601
Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation.
1 P26928 (/IMP)
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
1 P26927 (/IDA)
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
1 P26928 (/ISO)
Regulation of receptor signaling pathway via JAK-STAT GO:0046425
Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT.
1 P26928 (/IMP)
Hepatocyte growth factor receptor signaling pathway GO:0048012
The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands.
1 P26927 (/TAS)
Mammary duct terminal end bud growth GO:0060763
The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty.
1 P26928 (/IMP)
Negative regulation of epithelial cell apoptotic process GO:1904036
Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process.
1 P26928 (/IMP)
Regulation of cAMP-dependent protein kinase activity GO:2000479
Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity.
1 P26927 (/IDA)
Regulation of cAMP-dependent protein kinase activity GO:2000479
Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity.
1 P26928 (/ISO)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P26928 (/ISS) Q24K22 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 F7FMS0 (/IDA) P70521 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P26927 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P26927 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P26928 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P26928 (/ISO)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
1 P26928 (/IDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
1 P26927 (/HDA)
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