The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Trypsin-like serine proteases
".
FunFam 13: Coagulation factor X
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 24 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
|
12 |
P00741 (/ISS)
P16291 (/ISS)
P16292 (/ISS)
P16293 (/ISS)
P16294 (/ISS)
P16295 (/ISS)
P16296 (/ISS)
P19540 (/ISS)
Q6SA95 (/ISS)
Q804X6 (/ISS)
(2 more) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
12 |
P00741 (/ISS)
P16291 (/ISS)
P16292 (/ISS)
P16293 (/ISS)
P16294 (/ISS)
P16295 (/ISS)
P16296 (/ISS)
P19540 (/ISS)
Q6SA95 (/ISS)
Q804X6 (/ISS)
(2 more) |
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
11 |
A6MFK7 (/ISS)
A6MFK8 (/ISS)
B5G6G5 (/ISS)
P00745 (/ISS)
P31394 (/ISS)
P33587 (/ISS)
Q28278 (/ISS)
Q28661 (/ISS)
Q58L93 (/ISS)
Q58L95 (/ISS)
(1 more) |
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
10 | P00742 (/IDA) P00742 (/IDA) P00742 (/IDA) P00742 (/IDA) P81428 (/IDA) P82807 (/IDA) P83370 (/IDA) Q56VR3 (/IDA) Q58L94 (/IDA) Q58L96 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
10 | P00740 (/IPI) P00742 (/IPI) P00742 (/IPI) P00742 (/IPI) P00742 (/IPI) P04070 (/IPI) P08709 (/IPI) Q56VR3 (/IPI) Q58L95 (/IPI) Q58L96 (/IPI) |
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
6 | P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P04070 (/TAS) P08709 (/TAS) |
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
5 | P00742 (/IMP) P00742 (/IMP) P00742 (/IMP) P00742 (/IMP) P04070 (/IMP) |
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
4 | P00742 (/IDA) P00742 (/IDA) P00742 (/IDA) P00742 (/IDA) |
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
|
3 | P00740 (/IDA) P00741 (/IDA) Q8K3U6 (/IDA) |
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
|
3 | P16294 (/ISO) P70375 (/ISO) P70375 (/ISO) |
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
3 | O88947 (/ISO) O88947 (/ISO) P33587 (/ISO) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | P70375 (/ISO) P70375 (/ISO) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
2 | P00740 (/IDA) P00741 (/IDA) |
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
2 | O88947 (/ISO) O88947 (/ISO) |
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
2 | P16294 (/IDA) P33587 (/IDA) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | P00741 (/IDA) |
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
1 | P00740 (/NAS) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q8K3U6 (/IPI) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | P16294 (/ISO) |
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
1 | P08709 (/TAS) |
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
|
1 | P31394 (/IDA) |
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
|
1 | P33587 (/ISO) |
Oligopeptidase activity GO:0070012
Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds.
|
1 | P31394 (/IDA) |
Oligopeptidase activity GO:0070012
Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds.
|
1 | P33587 (/ISO) |
There are 83 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
11 |
P00741 (/ISS)
P16291 (/ISS)
P16292 (/ISS)
P16293 (/ISS)
P16295 (/ISS)
P16296 (/ISS)
P19540 (/ISS)
Q6SA95 (/ISS)
Q804X6 (/ISS)
Q95ND7 (/ISS)
(1 more) |
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
|
11 |
P00741 (/ISS)
P16291 (/ISS)
P16292 (/ISS)
P16293 (/ISS)
P16294 (/ISS)
P16295 (/ISS)
P19540 (/ISS)
Q6SA95 (/ISS)
Q804X6 (/ISS)
Q95ND7 (/ISS)
(1 more) |
Zymogen activation GO:0031638
The proteolytic processing of an inactive enzyme to an active form.
|
11 |
P16291 (/ISS)
P16292 (/ISS)
P16293 (/ISS)
P16294 (/ISS)
P16295 (/ISS)
P16296 (/ISS)
P19540 (/ISS)
Q6SA95 (/ISS)
Q804X6 (/ISS)
Q95ND7 (/ISS)
(1 more) |
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
|
7 | P00740 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P04070 (/TAS) P08709 (/TAS) |
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
|
6 | P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P04070 (/TAS) P08709 (/TAS) |
Negative regulation of blood coagulation GO:0030195
Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.
|
6 | A4FUL1 (/IDA) F1QPL4 (/IDA) P31394 (/IDA) P33587 (/IDA) Q504J5 (/IDA) Q8JHC9 (/IDA) |
Positive regulation of blood coagulation in other organism GO:0035807
Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot.
|
6 | P81428 (/IDA) P82807 (/IDA) P83370 (/IDA) Q56VR3 (/IDA) Q58L94 (/IDA) Q58L96 (/IDA) |
Envenomation resulting in positive regulation of blood coagulation in other organism GO:0044469
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of blood coagulation in the bitten organism.
|
6 | P81428 (/IDA) P82807 (/IDA) P83370 (/IDA) Q56VR3 (/IDA) Q58L94 (/IDA) Q58L96 (/IDA) |
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
6 | P00745 (/ISS) P31394 (/ISS) P33587 (/ISS) Q28278 (/ISS) Q28661 (/ISS) Q9GLP2 (/ISS) |
Negative regulation of coagulation GO:0050819
Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation.
|
6 | P00745 (/ISS) P31394 (/ISS) P33587 (/ISS) Q28278 (/ISS) Q28661 (/ISS) Q9GLP2 (/ISS) |
Positive regulation of establishment of endothelial barrier GO:1903142
Any process that activates or increases the frequency, rate or extent of establishment of endothelial barrier.
|
6 | P00745 (/ISS) P31394 (/ISS) P33587 (/ISS) Q28278 (/ISS) Q28661 (/ISS) Q9GLP2 (/ISS) |
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
|
5 | P00740 (/IDA) P08709 (/IDA) P16296 (/IDA) Q63207 (/IDA) Q8K3U6 (/IDA) |
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
|
5 | O88947 (/ISO) O88947 (/ISO) P16294 (/ISO) P70375 (/ISO) P70375 (/ISO) |
Blood coagulation, extrinsic pathway GO:0007598
A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X.
|
5 | P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P08709 (/TAS) |
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
5 | P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P08709 (/TAS) |
Positive regulation of blood coagulation in other organism GO:0035807
Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot.
|
5 | A6MFK7 (/ISS) A6MFK8 (/ISS) B5G6G5 (/ISS) Q58L93 (/ISS) Q58L95 (/ISS) |
Envenomation resulting in positive regulation of blood coagulation in other organism GO:0044469
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of blood coagulation in the bitten organism.
|
5 | A6MFK7 (/ISS) A6MFK8 (/ISS) B5G6G5 (/ISS) Q58L93 (/ISS) Q58L95 (/ISS) |
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
5 | P00742 (/IDA) P00742 (/IDA) P00742 (/IDA) P00742 (/IDA) P08709 (/IDA) |
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
|
4 | P00742 (/IC) P00742 (/IC) P00742 (/IC) P00742 (/IC) |
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
|
4 | P00740 (/IMP) P16294 (/IMP) P70375 (/IMP) P70375 (/IMP) |
Hemostasis GO:0007599
The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.
|
4 | F1QLC3 (/IMP) Q4V971 (/IMP) Q6PGW7 (/IMP) Q8JHC8 (/IMP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
4 | P00745 (/ISS) P33587 (/ISS) Q28661 (/ISS) Q9GLP2 (/ISS) |
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
4 | O88947 (/ISO) O88947 (/ISO) P70375 (/ISO) P70375 (/ISO) |
Blood coagulation, fibrin clot formation GO:0072378
A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events.
|
4 | F1QFP3 (/IMP) Q504H3 (/IMP) Q8JHD0 (/IMP) Q90YK1 (/IMP) |
Positive regulation of leukocyte chemotaxis GO:0002690
Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.
|
2 | P70375 (/ISO) P70375 (/ISO) |
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
2 | P00740 (/IDA) P31394 (/IDA) |
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
2 | P16294 (/ISO) P33587 (/ISO) |
Positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641
Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
|
2 | P70375 (/ISO) P70375 (/ISO) |
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
|
2 | P70375 (/ISO) P70375 (/ISO) |
Positive regulation of blood coagulation GO:0030194
Any process that activates or increases the frequency, rate or extent of blood coagulation.
|
2 | P70375 (/ISO) P70375 (/ISO) |
Zymogen activation GO:0031638
The proteolytic processing of an inactive enzyme to an active form.
|
2 | P00740 (/IDA) P00741 (/IDA) |
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
2 | P70375 (/ISO) P70375 (/ISO) |
Positive regulation of positive chemotaxis GO:0050927
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
|
2 | P70375 (/ISO) P70375 (/ISO) |
Response to anticoagulant GO:0061476
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticoagulant stimulus.
|
2 | P70375 (/ISO) P70375 (/ISO) |
Response to cholesterol GO:0070723
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
|
2 | P70375 (/ISO) P70375 (/ISO) |
Response to astaxanthin GO:1905217
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus.
|
2 | P70375 (/ISO) P70375 (/ISO) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | Q8K3U6 (/IEP) |
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
|
1 | P31394 (/IEP) |
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
|
1 | P33587 (/IMP) |
Positive regulation of leukocyte chemotaxis GO:0002690
Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.
|
1 | P08709 (/IDA) |
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
1 | P04070 (/NAS) |
Blood coagulation, intrinsic pathway GO:0007597
A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X.
|
1 | P00740 (/TAS) |
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | Q8K3U6 (/IEP) |
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | Q8K3U6 (/IEP) |
Response to carbon dioxide GO:0010037
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus.
|
1 | Q8K3U6 (/IEP) |
Positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641
Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
|
1 | P08709 (/IDA) |
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
1 | Q8K3U6 (/IEP) |
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
|
1 | P08709 (/IDA) |
Positive regulation of blood coagulation GO:0030194
Any process that activates or increases the frequency, rate or extent of blood coagulation.
|
1 | Q8K3U6 (/IDA) |
Negative regulation of blood coagulation GO:0030195
Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.
|
1 | P33587 (/IMP) |
Negative regulation of blood coagulation GO:0030195
Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.
|
1 | P33587 (/ISO) |
Negative regulation of blood coagulation GO:0030195
Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.
|
1 | P04070 (/TAS) |
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
|
1 | Q8K3U6 (/IEP) |
Zymogen activation GO:0031638
The proteolytic processing of an inactive enzyme to an active form.
|
1 | P16294 (/ISO) |
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
1 | Q8K3U6 (/IDA) |
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
1 | Q8K3U6 (/IEP) |
Response to vitamin K GO:0032571
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus.
|
1 | Q8K3U6 (/IEP) |
Response to genistein GO:0033595
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus.
|
1 | Q8K3U6 (/IEP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P04070 (/IMP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P33587 (/ISO) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P33587 (/NAS) |
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
|
1 | Q8K3U6 (/IEP) |
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
|
1 | P04070 (/TAS) |
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
1 | P04070 (/TAS) |
Regulation of circulating fibrinogen levels GO:0044537
Any process that modulates the quantity of fibrinogen circulating in the bloodstream.
|
1 | P33587 (/IMP) |
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
1 | P04070 (/IMP) |
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
1 | P33587 (/ISO) |
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
1 | P31394 (/TAS) |
Negative regulation of coagulation GO:0050819
Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation.
|
1 | P04070 (/IMP) |
Negative regulation of coagulation GO:0050819
Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation.
|
1 | P33587 (/ISO) |
Negative regulation of coagulation GO:0050819
Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation.
|
1 | P31394 (/TAS) |
Positive regulation of positive chemotaxis GO:0050927
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
|
1 | P08709 (/IDA) |
Response to growth hormone GO:0060416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth.
|
1 | Q8K3U6 (/IEP) |
Response to anticoagulant GO:0061476
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticoagulant stimulus.
|
1 | Q8K3U6 (/IDA) |
Response to cholesterol GO:0070723
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
|
1 | Q8K3U6 (/IDA) |
Response to thyroid hormone GO:0097066
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
|
1 | Q8K3U6 (/IEP) |
Response to thyroxine GO:0097068
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus.
|
1 | Q8K3U6 (/IEP) |
Positive regulation of establishment of endothelial barrier GO:1903142
Any process that activates or increases the frequency, rate or extent of establishment of endothelial barrier.
|
1 | P04070 (/IMP) |
Positive regulation of establishment of endothelial barrier GO:1903142
Any process that activates or increases the frequency, rate or extent of establishment of endothelial barrier.
|
1 | P33587 (/ISO) |
Response to Thyroid stimulating hormone GO:1904400
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus.
|
1 | Q8K3U6 (/IEP) |
Response to 2,3,7,8-tetrachlorodibenzodioxine GO:1904612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus.
|
1 | Q8K3U6 (/IEP) |
Response to astaxanthin GO:1905217
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus.
|
1 | Q8K3U6 (/IDA) |
Response to thyrotropin-releasing hormone GO:1905225
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.
|
1 | Q8K3U6 (/IEP) |
There are 28 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
12 |
P00741 (/ISS)
P16291 (/ISS)
P16292 (/ISS)
P16293 (/ISS)
P16294 (/ISS)
P16295 (/ISS)
P16296 (/ISS)
P19540 (/ISS)
Q6SA95 (/ISS)
Q804X6 (/ISS)
(2 more) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
9 | P00740 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P04070 (/TAS) P08709 (/TAS) P70375 (/TAS) P70375 (/TAS) |
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
7 | P00740 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P04070 (/TAS) P08709 (/TAS) |
Golgi lumen GO:0005796
The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.
|
7 | P00740 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P04070 (/TAS) P08709 (/TAS) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
6 | P81428 (/IDA) P82807 (/IDA) P83370 (/IDA) Q56VR3 (/IDA) Q58L94 (/IDA) Q58L96 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
6 | P00740 (/NAS) P00742 (/NAS) P00742 (/NAS) P00742 (/NAS) P00742 (/NAS) P04070 (/NAS) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
6 | P00745 (/ISS) P31394 (/ISS) P33587 (/ISS) Q28278 (/ISS) Q28661 (/ISS) Q9GLP2 (/ISS) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
6 | P00745 (/ISS) P31394 (/ISS) P33587 (/ISS) Q28278 (/ISS) Q28661 (/ISS) Q9GLP2 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | P00740 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P00742 (/TAS) P08709 (/TAS) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
5 | A6MFK7 (/ISS) A6MFK8 (/ISS) B5G6G5 (/ISS) Q58L93 (/ISS) Q58L95 (/ISS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
4 | P16294 (/ISO) P33587 (/ISO) P70375 (/ISO) P70375 (/ISO) |
Intrinsic component of external side of plasma membrane GO:0031233
The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor.
|
4 | P00742 (/IC) P00742 (/IC) P00742 (/IC) P00742 (/IC) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
3 | P00740 (/IDA) P31394 (/IDA) Q8K3U6 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
3 | O88947 (/ISO) O88947 (/ISO) P33587 (/ISO) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
2 | P04070 (/IDA) Q63207 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | O88947 (/ISO) O88947 (/ISO) |
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
|
2 | P70375 (/ISO) P70375 (/ISO) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
2 | Q56VR3 (/IDA) Q58L96 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | O88947 (/ISO) O88947 (/ISO) |
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
|
2 | P00740 (/HDA) P08709 (/HDA) |
Serine-type peptidase complex GO:1905286
A protein complex which is capable of serine-type peptidase activity.
|
2 | P70375 (/ISO) P70375 (/ISO) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | P04070 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | P33587 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q63207 (/IDA) |
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
|
1 | Q8K3U6 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | Q63207 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P00740 (/HDA) |
Serine-type peptidase complex GO:1905286
A protein complex which is capable of serine-type peptidase activity.
|
1 | P08709 (/IPI) |