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CATH Superfamily 2.30.39.10

Alpha-1-antitrypsin, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Alpha-1-antitrypsin, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Serpin family B member 2
541
3D
 1uhgD01 - 94.1
2
Serpin family D member 1
416
3D
 6hgnA02 - 96.8
3
alpha-1-antitrypsin isoform X1
291
3D
 9apiA01 - 82.7
6
Plasminogen activator inhibitor 1
142
3D
 3lw2A02 - 93.3
4
Serpin peptidase inhibitor, clade H, member 1
138 - - 91.8
11
Antithrombin-III
115
3D
 4eb1L02 - 77.8
5
neuroserpin isoform X1
102
3D
 3fgqB01 - 61.7
8
Serpin B5 isoform B
91
3D
 1xu8B02 - 79.5
7
pigment epithelium-derived factor isoform X2
88
3D
 1imvA01 - 65.2
9
Glia-derived nexin isoform 2
87
3D
 4dy7F02 - 45.8
10
Serpin family F member 2
82
3D
 2r9yA02 - 84.6
18
Angiotensinogen
51
3D
 2wy0C01 - 91.2
14
Serpin family B member 9
49
3D
 4ga7B02 - 81.0
15
Serpin family G member 1
47
3D
 2oayA02 - 89.7
12
Serpin family E member 3
47 - - 85.4
13
Serpin family I member 2
46 - - 83.3
16
Probable non-inhibitory serpin-Z5
45
3D
 3le2A02 - 90.2
17
Serpin family A member 10
45
3D
 3h5cA02 - 76.7
19
Serpin 4
41
3D
 4p0oA02 - 95.8
72
Serpin peptidase inhibitor, clade H
Heat shock protein 47 Collagen binding protein 1
31
3D
 4au4G02 - 24.3
20
Serpin family B member 8
30 - - 34.3
61
Serpin 2
26
3D
 4rsqL01 - 53.1
21
Serpin family B member 9
26 - - 76.2
22
Os11g0230400 protein
22 - - 83.2
50
Heterochromatin-associated protein MENT
18
3D
 2h4rA02 - 75.3
23
SeRPin
17 - - 88.4
25
Serpin 77Bb
16 - - 94.4
24
Spn43Ac
16 - - 18.0
26
Serpin 38F, isoform A
15 - - 80.3
28
Uncharacterized protein
13 - - 90.3
27
Serpin peptidase inhibitor 29
13 - - 83.7
29
SeRPin
12 - - 76.7
30
Serpin 2
12 - - 96.5
34
Serine proteinase inhibitor 2
12
3D
 1f0cA02 - 18.4
33
LP08647p
11 - - 22.1
31
Probable non-inhibitory serpin-Z9
11 - - 82.8
32
Uteroferrin-associated basic protein 2
11 - - 79.7
35
Serine protease inhibitor
serpin
11 - - 89.7
36
Putative non-inhibitory serpin-10
11 - - 76.1
37
Os11g0224800 protein
10 - - 71.3
71
Serpin B3
10
3D
 4zk3A02 - 53.4
39
Uncharacterized protein
9 - - 2.6
44
Alaserpin
9
3D
 1k9oI02 - 92.2
40
Serpin peptidase inhibitor 7
9 - - 91.7
38
Os01g0267300 protein
9 - - 50.2
53
Serpin-2 precursor, putative
8
3D
 3ndaB02 - 84.3
42
leukocyte elastase inhibitor-like isoform X1
8 - - 95.9
41
Serpin-Z1
8 - - 29.0
43
Serpin 7 precursor, putative
8 - - 97.6
46
Serine protease inhibitor 28Dc
7 - - 85.5
45
Blast:Leukocyte elastase inhibitor
7 - - 46.9
47
Serpin-1 precursor, putative
7 - - 84.5
48
Serine protease inhibitor
serpin
7 - - 18.7
49
Serpin 100A
7 - - 10.3
65
Serpin family A member 5
7
3D
 3dy0A02 - 23.7
59
Serpin family B member 8
6 - - 74.3
58
Putative serpin A13
6 - - 21.6
57
Angiotensinogen
6 - - 83.8
60
Serpin peptidase inhibitor 31
6 - - 71.7
51
Serpin-Z2A
6 - - 22.7
54
Serpin peptidase inhibitor, clade C
antithrombin
6 - - 9.6
52
Serpin peptidase inhibitor, clade F
alpha-2 antiplasmin, pigment epithelium-derived factor
6 - - 50.9
55
GM21844
6 - - 12.2
62
Serpin peptidase inhibitor 4
6 - - 77.6
56
leukocyte elastase inhibitor
6 - - 15.7
63
Leukocyte elastase inhibitor, putative
5 - - 0.8
68
Uncharacterized protein
5 - - 53.0
69
Serine protease inhibitor
serpin
5 - - 18.3
67
GM17927
5 - - 8.9
64
GM19657
5 - - 13.1
66
Serpin 42Dc, isoform A
5 - - 13.5
70
Blast:Serpin B8
5 - - 10.3
83
Serpin-2 precursor, putative
4 - - 70.7
78
GM20478
4 - - 5.4
79
Serine protease inhibitor 27A
4 - - 13.9
73
RCG21015, isoform CRA_a
4 - - 23.2
81
Antithrombin-III
4 - - 16.5
80
Accessory gland protein Acp76A
4 - - 4.3
75
Uncharacterized protein
4 - - 68.0
76
Serine protease inhibitor
SERPIN
4 - - 69.1
77
Serpin 42De, isoform B
4 - - 8.3
82
Putative non-inhibitory serpin-Z11
4 - - 0.0
74
Predicted protein
4 - - 54.0
89
Serpin peptidase inhibitor 22
3 - - 0.0
88
AGAP009670-PA
3 - - 73.1
84
Serine protease inhibitor
serpin
3 - - 13.5
91
Phosphotransferase
3 - - 4.4
90
Serpin peptidase inhibitor, clade G
C1 inhibitor
3 - - 1.8
87
Serpin 1
3 - - 5.6
86
GM20003
3 - - 9.3
85
Serine protease inhibitor serpin
3 - - 3.1
104
Uncharacterized protein
2 - - 0.0
105
Serpin family B member 8
2 - - 4.2
93
Proteinase inhibitor I4 serpin
2 - - 39.2
100
Protein CBG10463
2 - - 41.5
98
Serine protease inhibitor
Serpin-2
2 - - 0.0
99
Serin peptidase inhibitor, clade A
Alpha-1 antiproteinase, antitrypsin
2 - - 5.5
97
AGAP006909-PA
2 - - 9.2
94
Uncharacterized protein
2 - - 0.0
103
Protein CBG15466
2 - - 7.2
102
Serpin-Z1
2 - - 32.3
92
Serpin 42Db, isoform D
2 - - 11.7
95
Serpin 7
2 - - 0.0
96
serine protease inhibitor isoform X1
2 - - 12.4
106
Serpin peptidase inhibitor 4
2 - - 3.0
101
Uncharacterized protein
2 - - 37.5
147
Uncharacterized protein
1 - - 0.0
107
Uncharacterized protein
1 - - 0.0
114
Male accessory gland protein
1 - - 0.0
160
Serpin, putative
1 - - 0.0
117
Serpin A3-8
1 - - 0.0
144
Uncharacterized protein
1 - - 0.0
149
Serine protease inhibitor, putative
1 - - 0.0
109
Uncharacterized protein
1 - - 0.0
119
Uncharacterized protein
1 - - 0.0
115
Serpin peptidase inhibitor 1
1 - - 0.0
133
Serpin peptidase inhibitor clade I neuroserpin member 1
1 - - 0.0
158
Uncharacterized protein
1 - - 0.0
128
Uncharacterized protein
1 - - 0.0
145
Serpin, putative
1 - - 0.0
150
Uncharacterized protein
1 - - 0.0
120
Uncharacterized protein
1 - - 0.0
140
Serpin peptidase inhibitor 7
1 - - 0.0
164
Uncharacterized protein
1 - - 0.0
110
Uncharacterized protein
1 - - 0.0
108
Serpin peptidase inhibitor 27
1 - - 0.0
125
Uncharacterized protein
1 - - 0.0
148
Serpin peptidase inhibitor 31
1 - - 0.0
132
Uncharacterized protein
1 - - 0.0
118
Uncharacterized protein
1 - - 0.0
155
Uncharacterized protein
1 - - 0.0
159
Uncharacterized protein
1 - - 0.0
136
Uncharacterized protein
1 - - 0.0
131
Angiotensinogen
1 - - 0.0
129
Serpin, putative
1 - - 0.0
157
Uncharacterized protein
1 - - 0.0
124
Protein CBG06349
1 - - 0.0
127
Uncharacterized protein
1 - - 0.0
154
Uncharacterized protein
1 - - 0.0
121
SERPINB5 protein
1 - - 0.0
126
Serpin-4 precursor, putative
1 - - 0.0
151
Protein CBG10463
1 - - 0.0
156
Uncharacterized protein
1 - - 0.0
162
Uncharacterized protein
1 - - 0.0
139
Uncharacterized protein
1 - - 0.0
134
Uncharacterized protein
1 - - 0.0
137
Serpin, putative
1 - - 0.0
135
Serpin, putative
1 - - 0.0
161
Serine protease inhibitor, putative
1 - - 0.0
113
Serpin peptidase inhibitor 8
1 - - 0.0
152
Serpin peptidase inhibitor, clade B
ovalbumin
1 - - 0.0
143
Serpin-Z1
1 - - 0.0
122
Serpin-2 precursor, putative
1 - - 0.0
123
Secreted salivary gland peptide, putative
1 - - 0.0
142
Uncharacterized protein
1 - - 0.0
138
Uncharacterized protein
1 - - 0.0
153
Uncharacterized protein
1 - - 0.0
112
AGAP006910-PA
1 - - 0.0
130
Uncharacterized protein
1 - - 0.0
111
Serpin, putative
1 - - 0.0
163
Uncharacterized protein
1 - - 0.0
116
Serpin family I member 2
1 - - 0.0
141
Uncharacterized protein
1 - - 0.0
146
Serpin peptidase inhibitor 6
1 - - 0.0
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