CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 3: Radixin isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 55 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
49 |
E2QZZ2 (/IPI)
G5EBK3 (/IPI)
P15311 (/IPI)
P15311 (/IPI)
P15311 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
(39 more) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
18 |
A0A0G2K095 (/IDA)
E9PT65 (/IDA)
O35763 (/IDA)
P15311 (/IDA)
P15311 (/IDA)
P15311 (/IDA)
P35241 (/IDA)
P35241 (/IDA)
P35241 (/IDA)
P35241 (/IDA)
(8 more) |
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
|
18 |
P15311 (/IPI)
P15311 (/IPI)
P15311 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
(8 more) |
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
|
15 |
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
(5 more) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
15 |
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
(5 more) |
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
|
15 |
P26038 (/TAS)
P26038 (/TAS)
P26038 (/TAS)
P26038 (/TAS)
P26038 (/TAS)
P26038 (/TAS)
P26038 (/TAS)
P26038 (/TAS)
P26038 (/TAS)
P26038 (/TAS)
(5 more) |
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
15 |
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
(5 more) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
15 |
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
P26038 (/IPI)
(5 more) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
10 | P15311 (/HDA) P15311 (/HDA) P15311 (/HDA) P35241 (/HDA) P35241 (/HDA) P35241 (/HDA) P35241 (/HDA) P35241 (/HDA) P35241 (/HDA) P35241 (/HDA) |
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
10 | P15311 (/HDA) P15311 (/HDA) P15311 (/HDA) P35241 (/HDA) P35241 (/HDA) P35241 (/HDA) P35241 (/HDA) P35241 (/HDA) P35241 (/HDA) P35241 (/HDA) |
Showing 1 to 10 of 55 entries
There are 236 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
29 |
P15311 (/IMP)
P15311 (/IMP)
P15311 (/IMP)
P26038 (/IMP)
P26038 (/IMP)
P26038 (/IMP)
P26038 (/IMP)
P26038 (/IMP)
P26038 (/IMP)
P26038 (/IMP)
(19 more) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
25 |
P15311 (/IGI)
P15311 (/IGI)
P15311 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
(15 more) |
Establishment of endothelial barrier GO:0061028
The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.
|
25 |
P15311 (/IGI)
P15311 (/IGI)
P15311 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
(15 more) |
Regulation of organelle assembly GO:1902115
Any process that modulates the frequency, rate or extent of organelle assembly.
|
25 |
P15311 (/IGI)
P15311 (/IGI)
P15311 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
(15 more) |
Positive regulation of protein localization to early endosome GO:1902966
Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.
|
25 |
P15311 (/IGI)
P15311 (/IGI)
P15311 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
(15 more) |
Positive regulation of cellular protein catabolic process GO:1903364
Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process.
|
25 |
P15311 (/IGI)
P15311 (/IGI)
P15311 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
(15 more) |
Positive regulation of early endosome to late endosome transport GO:2000643
Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport.
|
25 |
P15311 (/IGI)
P15311 (/IGI)
P15311 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
P26038 (/IGI)
(15 more) |
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
|
18 |
P15311 (/IEP)
P15311 (/IEP)
P15311 (/IEP)
P26038 (/IEP)
P26038 (/IEP)
P26038 (/IEP)
P26038 (/IEP)
P26038 (/IEP)
P26038 (/IEP)
P26038 (/IEP)
(8 more) |
Membrane to membrane docking GO:0022614
The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere.
|
18 |
P15311 (/IEP)
P15311 (/IEP)
P15311 (/IEP)
P26038 (/IEP)
P26038 (/IEP)
P26038 (/IEP)
P26038 (/IEP)
P26038 (/IEP)
P26038 (/IEP)
P26038 (/IEP)
(8 more) |
Immunological synapse formation GO:0001771
The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
|
15 |
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
(5 more) |
Showing 1 to 10 of 236 entries
There are 137 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
105 |
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1F6 (/IDA)
A0A024R1F6 (/IDA)
(95 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
79 |
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1D9 (/IDA)
A0A024R1F6 (/IDA)
A0A024R1F6 (/IDA)
(69 more) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
37 |
G5EBK3 (/IDA)
P15311 (/IDA)
P15311 (/IDA)
P15311 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
(27 more) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
26 |
P15311 (/HDA)
P15311 (/HDA)
P15311 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
(16 more) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
25 |
P15311 (/HDA)
P15311 (/HDA)
P15311 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
(15 more) |
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
|
25 |
A0A0G2K095 (/IDA)
E9PT65 (/IDA)
P15311 (/IDA)
P15311 (/IDA)
P15311 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
(15 more) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
25 |
P15311 (/HDA)
P15311 (/HDA)
P15311 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
P26038 (/HDA)
(15 more) |
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
|
25 |
G5EBK3 (/IDA)
G5EES2 (/IDA)
P15311 (/IDA)
P15311 (/IDA)
P15311 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
(15 more) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
25 |
P15311 (/IDA)
P15311 (/IDA)
P15311 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
(15 more) |
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
|
25 |
P15311 (/IDA)
P15311 (/IDA)
P15311 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
P26038 (/IDA)
(15 more) |
Showing 1 to 10 of 137 entries