The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 21: Rho guanine nucleotide exchange factor 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 32 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P97433 (/IPI) Q12802 (/IPI) Q5FVC2 (/IPI) Q60875 (/IPI) Q865S3 (/IPI) Q92974 (/IPI)
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
5 B2DCZ9 (/ISS) F1M3G7 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
4 E9Q394 (/IDA) Q12802 (/IDA) Q60875 (/IDA) Q92974 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Rac guanyl-nucleotide exchange factor activity GO:0030676
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
3 B2DCZ9 (/IDA) F1RLP5 (/IDA) Q92974 (/IDA)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
3 B2DCZ9 (/IDA) F1RLP5 (/IDA) Q92974 (/IDA)
MAP-kinase scaffold activity GO:0005078
The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
2 E9Q394 (/ISS) F1M3G7 (/ISS)
Showing 1 to 10 of 32 entries

There are 112 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Negative regulation of microtubule depolymerization GO:0007026
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Cellular response to muramyl dipeptide GO:0071225
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Positive regulation of neuron migration GO:2001224
Any process that activates or increases the frequency, rate or extent of neuron migration.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q865S3 (/ISS) Q92974 (/ISS)
Showing 1 to 10 of 112 entries

There are 46 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 A0A087WTD7 (/IDA) A0A087WZG4 (/IDA) A8MYJ1 (/IDA) Q12802 (/IDA) Q6ZSZ5 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q12802 (/TAS) Q6ZSZ5 (/TAS) Q8N1W1 (/TAS) Q92974 (/TAS)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
4 B2DCZ9 (/ISS) Q5FVC2 (/ISS) Q60875 (/ISS) Q865S3 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 A0A286YAR8 (/IDA) F1QCK8 (/IDA) Q92974 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 E9Q394 (/ISO) Q6P9R4 (/ISO)
Showing 1 to 10 of 46 entries
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