Structural domains comprising this superfamily share the structure of the ribosomal protein L24, found in eukaryotes (L24) and archaea (L24e, different from L24) and located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor binding site. L24e/L24 appears to be involved in the kinetics of peptide synthesis, and it has been suggested to mediate interactions between the large and small subunits, directly or through other factors. The protein is composed of a single structural domain which forms an alpha/beta zinc-binding fold.

In mouse, a deletion mutation in L24 has been identified as the cause for the belly spot and tail (Bst) mutation that results in disrupted pigmentation, somitogenesis and retinal cell fate determination PMID:15289434. L24 may be an important protein in eukaryotic reproduction: in shrimp, L24 expression is elevated in the ovary, suggesting a role in oogenesis, and in Arabidopsis, L24 has been proposed to have a specific function in gynoecium development PMID:17462931,PMID:15270688.

PFAM:PF01246, INTERPRO:IPR000988