The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: NAD-dependent deacetylase sirtuin-7

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
4 Q9NRC8 (/IDA) Q9NRC8 (/IDA) Q9NRC8 (/IDA) Q9NRC8 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q9NRC8 (/IPI) Q9NRC8 (/IPI) Q9NRC8 (/IPI) Q9NRC8 (/IPI)
NAD-dependent histone deacetylase activity (H3-K18 specific) GO:0097372
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein.
4 Q9NRC8 (/IDA) Q9NRC8 (/IDA) Q9NRC8 (/IDA) Q9NRC8 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
3 B2RZ55 (/ISS) Q0P595 (/ISS) Q8BKJ9 (/ISS)
NAD-dependent histone deacetylase activity (H3-K18 specific) GO:0097372
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein.
3 B2RZ55 (/ISS) Q0P595 (/ISS) Q8BKJ9 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q8BKJ9 (/ISO)
NAD-dependent histone deacetylase activity (H3-K18 specific) GO:0097372
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein.
1 Q8BKJ9 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
4 Q9NRC8 (/IDA) Q9NRC8 (/IDA) Q9NRC8 (/IDA) Q9NRC8 (/IDA)
Positive regulation of transcription involved in exit from mitosis GO:0007072
Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
4 Q9NRC8 (/IMP) Q9NRC8 (/IMP) Q9NRC8 (/IMP) Q9NRC8 (/IMP)
RRNA transcription GO:0009303
The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.
4 Q9NRC8 (/IMP) Q9NRC8 (/IMP) Q9NRC8 (/IMP) Q9NRC8 (/IMP)
Histone H3 deacetylation GO:0070932
The modification of histone H3 by the removal of one or more acetyl groups.
4 Q9NRC8 (/IDA) Q9NRC8 (/IDA) Q9NRC8 (/IDA) Q9NRC8 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 B2RZ55 (/ISS) Q0P595 (/ISS) Q8BKJ9 (/ISS)
Histone H3 deacetylation GO:0070932
The modification of histone H3 by the removal of one or more acetyl groups.
3 B2RZ55 (/ISS) Q0P595 (/ISS) Q8BKJ9 (/ISS)
Positive regulation of transcription involved in exit from mitosis GO:0007072
Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
2 Q0P595 (/ISS) Q8BKJ9 (/ISS)
RRNA transcription GO:0009303
The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.
2 Q0P595 (/ISS) Q8BKJ9 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q8BKJ9 (/ISO)
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
1 A0A2R8QUG9 (/IMP)
Positive regulation of transcription involved in exit from mitosis GO:0007072
Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
1 Q8BKJ9 (/ISO)
RRNA transcription GO:0009303
The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.
1 Q8BKJ9 (/ISO)
Histone H3 deacetylation GO:0070932
The modification of histone H3 by the removal of one or more acetyl groups.
1 Q8BKJ9 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
4 Q9NRC8 (/IDA) Q9NRC8 (/IDA) Q9NRC8 (/IDA) Q9NRC8 (/IDA)
Nucleolus organizer region GO:0005731
A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed.
4 Q9NRC8 (/IDA) Q9NRC8 (/IDA) Q9NRC8 (/IDA) Q9NRC8 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q0P595 (/ISS) Q8BKJ9 (/ISS)
Nucleolus organizer region GO:0005731
A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed.
2 Q0P595 (/ISS) Q8BKJ9 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9VAQ1 (/ISS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q8BKJ9 (/ISO)
Nucleolus organizer region GO:0005731
A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed.
1 Q8BKJ9 (/ISO)
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