The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
SET domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Histone-lysine N-methyltransferase SETMARHistone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6Histone-lysine N-methyltransferase family member SUVH9Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4Histone-lysine N-methyltransferase, H3 lysine-9 specificSC:2PR domain zinc finger protein 2SC:3PR domain zinc finger protein 10PR domain-containing protein 11PR domain zinc finger protein 1SC:4Histone-lysine N-methyltransferase SETD7Histone-lysine N-methyltransferase, putativeChromosome 1, whole genome shotgun sequenceSC:5Putative histone-lysine N-methyltransferase EZH2SC:6Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferase ATXR5SC:7Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseEuchromatic histone-lysine N-methyltransferase 2Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseSET domain-containing protein 5Histone-lysine N-methyltransferasePR domain zinc finger protein 8Histone-lysine N-methyltransferase SMYD1 isoform 1Zinc finger proteinHistone-lysine N-methyltransferasePR domain zinc finger protein 12Histone-lysine N-methyltransferasePR domain zinc finger protein 4putative histone-lysine N-methyltransferase PRDM6MDS1 and EVI1 complex locus protein isoform X1PR domain zinc finger protein 13Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferase SETDB2Histone-lysine N-methyltransferase ATX4probable histone-lysine N-methyltransferase PRDM7PR domain containing 14Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseBlimp-1, isoform AHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferase SMYD3Histone-lysine N-methyltransferaseVariant-silencing SET proteinHistone-lysine N-methyltransferaseZinc finger protein 408Putative zinc finger protein ZFPM2SET-domain containing protein lysine methyltransferase family proteinHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferase, putativeSET and MYND domain-containing protein 4Histone-lysine N-methyltransferaseBlast:Chromosome-associated kinesin KIF4APR/SET domain 2Histone-lysine N-methyltransferase, H3 lysine-4 specificHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferasePotential protein lysine methyltransferase SET5SET domain containing proteinDown and out, isoform AHistone-lysine N-methyltransferase, H3 lysine-36 specificSET domain protein, putativeSET_domain_containing_protein_-_putativeHistone-lysine N-methyltransferase ATXR3Histone-lysine N-methyltransferaseUncharacterized protein, isoform DSET domain-containing proteinprotein mstaprotein mstaDown and out, isoform ASET (Trithorax/polycomb) domain containingAGAP013139-PAPR domain 14Histone-lysine N-methyltransferase 2DHistone-lysine N-methyltransferaseprotein mstaSMYD family member 5GM24661SET (Trithorax/polycomb) domain containingGD10068Histone-lysine N-methyltransferasePR/SET domain 2UpSET, isoform AHistone-lysine N-methyltransferaseZinc finger proteinPredicted proteinN-lysine methyltransferase SMYD2SET-8Uncharacterized proteinPleiomorphic adenoma gene-like 1Histone-lysine N-methyltransferaseGM20595Uncharacterized proteinHistone-lysine N-methyltransferase set-26Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferase Su(var)3-9PR domain-containing 2, with ZNF domain bPutative positive regulatory Domain/B-lymphocyte induced maturation protein 1, version BAGAP013275-PAHamlet, isoform BPR/SET domain 16Uncharacterized proteinHistone-lysine N-methyltransferaseN-lysine methyltransferase KMT5A-BHistone-lysine N-methyltransferase SETD5Histone-lysine N-methyltransferase SUVR5Histone-lysine N-methyltransferaseProbable histone-lysine N-methyltransferase lin-59ATP-grasp domain containing protein, putativeHistone-lysine N-methyltransferasePR domain zinc finger protein 10-like ProteinUncharacterized proteinPrdm2 proteinPR domain zinc finger protein 10Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferasePredicted proteinHistone-lysine N-methyltransferaseSET (Trithorax/polycomb) domain containingPR domain-containing 1b, with ZNF domainPR domain 4Histone-lysine N-methyltransferaseEuchromatic histone lysine N-methyltransferase 2aHistone-lysine N-methyltransferase Clr4 (AFU_orthologue AFUA_1G11090)SMYD family member 5Histone-lysine N-methyltransferaseUncharacterized proteinHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPutative transcription factor blimp-1/prdi-bf1Predicted proteinPR domain zinc finger protein 13Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseSET domain containing protein, putativeSET domain containing protein, putativeUncharacterized proteinHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseUncharacterized proteinPredicted proteinMyeloid/lymphoid or mixed-lineage leukemiaPR/SET domain 13SET (Trithorax/polycomb) domain containingProtein CBG24719PR domain-containing 11Histone-lysine N-methyltransferaseUncharacterized proteinUncharacterized proteinProtein CBG24432PR domain containing 15Histone methyltransferaseUncharacterized proteinUncharacterized proteinPredicted proteinSET domain containing 5Histone-lysine N-methyltransferaseUncharacterized proteinUncharacterized proteinNuclear receptor binding SET domain protein 1bUncharacterized proteinUncharacterized proteinUncharacterized proteinHistone-lysine N-methyltransferase set-1Si:dkeyp-41f9.4PR domain containing 11PR domain containing 1cUncharacterized proteinUncharacterized proteinMyeloid/lymphoid or mixed-lineage leukemiaPR/SET domain 8PR domain 4Si:dkeyp-41f9.4Uncharacterized proteinUncharacterized proteinUncharacterized proteinHistone-lysine N-methyltransferaseUncharacterized proteinHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseUncharacterized proteinHistone-lysine N-methyltransferasePredicted proteinUncharacterized proteinHistone-lysine N-methyltransferaseUncharacterized proteinHistone-binding proteinSET domain-containing protein 3Uncharacterized proteinHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseUncharacterized proteinUncharacterized proteinPredicted proteinWhsc1 proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseSET and MYND domain-containing protein DDB_G0288495Uncharacterized proteinSET domain-containing proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinAGAP003597-PAUncharacterized proteinPredicted proteinHistone-lysine N-methyltransferaseUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinHistone-lysine N-methyltransferaseSET domain-containing protein 5Histone-lysine N-methyltransferaseUncharacterized proteinUncharacterized proteinSET and MYND domain containing, arthropod-specific, member 4, isoform CBAH domaincontaining proteinUncharacterized proteinPR/SET domain 12Uncharacterized proteinPR domain containing 4Uncharacterized proteinUncharacterized proteinNuclear receptor-binding SET domain protein 1SET and MYND domain containing 1bSET and MYND domain-containing protein DDB_G0288495SET and MYND domain containing 1aHistone-lysine N-methyltransferaseEukaryotic translation initiation factor 2 subunit 3-like Protein
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FunFam 80: SET (Trithorax/polycomb) domain containing

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 0 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

There are 0 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 P91821 (/HDA) Q8I4F7 (/HDA)
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
2 P91821 (/HDA) Q8I4F7 (/HDA)
Striated muscle dense body GO:0055120
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
2 P91821 (/HDA) Q8I4F7 (/HDA)
Showing 1 to 3 of 3 entries
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