The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
SET domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Histone-lysine N-methyltransferase SETMARHistone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6Histone-lysine N-methyltransferase family member SUVH9Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4Histone-lysine N-methyltransferase, H3 lysine-9 specificSC:2PR domain zinc finger protein 2SC:3PR domain zinc finger protein 10PR domain-containing protein 11PR domain zinc finger protein 1SC:4Histone-lysine N-methyltransferase SETD7Histone-lysine N-methyltransferase, putativeChromosome 1, whole genome shotgun sequenceSC:5Putative histone-lysine N-methyltransferase EZH2SC:6Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferase ATXR5SC:7Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseEuchromatic histone-lysine N-methyltransferase 2Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseSET domain-containing protein 5Histone-lysine N-methyltransferasePR domain zinc finger protein 8Histone-lysine N-methyltransferase SMYD1 isoform 1Zinc finger proteinHistone-lysine N-methyltransferasePR domain zinc finger protein 12Histone-lysine N-methyltransferasePR domain zinc finger protein 4putative histone-lysine N-methyltransferase PRDM6MDS1 and EVI1 complex locus protein isoform X1PR domain zinc finger protein 13Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferase SETDB2Histone-lysine N-methyltransferase ATX4probable histone-lysine N-methyltransferase PRDM7PR domain containing 14Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseBlimp-1, isoform AHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferase SMYD3Histone-lysine N-methyltransferaseVariant-silencing SET proteinHistone-lysine N-methyltransferaseZinc finger protein 408Putative zinc finger protein ZFPM2SET-domain containing protein lysine methyltransferase family proteinHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferase, putativeSET and MYND domain-containing protein 4Histone-lysine N-methyltransferaseBlast:Chromosome-associated kinesin KIF4APR/SET domain 2Histone-lysine N-methyltransferase, H3 lysine-4 specificHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferasePotential protein lysine methyltransferase SET5SET domain containing proteinDown and out, isoform AHistone-lysine N-methyltransferase, H3 lysine-36 specificSET domain protein, putativeSET_domain_containing_protein_-_putativeHistone-lysine N-methyltransferase ATXR3Histone-lysine N-methyltransferaseUncharacterized protein, isoform DSET domain-containing proteinprotein mstaprotein mstaDown and out, isoform ASET (Trithorax/polycomb) domain containingAGAP013139-PAPR domain 14Histone-lysine N-methyltransferase 2DHistone-lysine N-methyltransferaseprotein mstaSMYD family member 5GM24661SET (Trithorax/polycomb) domain containingGD10068Histone-lysine N-methyltransferasePR/SET domain 2UpSET, isoform AHistone-lysine N-methyltransferaseZinc finger proteinPredicted proteinN-lysine methyltransferase SMYD2SET-8Uncharacterized proteinPleiomorphic adenoma gene-like 1Histone-lysine N-methyltransferaseGM20595Uncharacterized proteinHistone-lysine N-methyltransferase set-26Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferase Su(var)3-9PR domain-containing 2, with ZNF domain bPutative positive regulatory Domain/B-lymphocyte induced maturation protein 1, version BAGAP013275-PAHamlet, isoform BPR/SET domain 16Uncharacterized proteinHistone-lysine N-methyltransferaseN-lysine methyltransferase KMT5A-BHistone-lysine N-methyltransferase SETD5Histone-lysine N-methyltransferase SUVR5Histone-lysine N-methyltransferaseProbable histone-lysine N-methyltransferase lin-59ATP-grasp domain containing protein, putativeHistone-lysine N-methyltransferasePR domain zinc finger protein 10-like ProteinUncharacterized proteinPrdm2 proteinPR domain zinc finger protein 10Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferasePredicted proteinHistone-lysine N-methyltransferaseSET (Trithorax/polycomb) domain containingPR domain-containing 1b, with ZNF domainPR domain 4Histone-lysine N-methyltransferaseEuchromatic histone lysine N-methyltransferase 2aHistone-lysine N-methyltransferase Clr4 (AFU_orthologue AFUA_1G11090)SMYD family member 5Histone-lysine N-methyltransferaseUncharacterized proteinHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPutative transcription factor blimp-1/prdi-bf1Predicted proteinPR domain zinc finger protein 13Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseSET domain containing protein, putativeSET domain containing protein, putativeUncharacterized proteinHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseUncharacterized proteinPredicted proteinMyeloid/lymphoid or mixed-lineage leukemiaPR/SET domain 13SET (Trithorax/polycomb) domain containingProtein CBG24719PR domain-containing 11Histone-lysine N-methyltransferaseUncharacterized proteinUncharacterized proteinProtein CBG24432PR domain containing 15Histone methyltransferaseUncharacterized proteinUncharacterized proteinPredicted proteinSET domain containing 5Histone-lysine N-methyltransferaseUncharacterized proteinUncharacterized proteinNuclear receptor binding SET domain protein 1bUncharacterized proteinUncharacterized proteinUncharacterized proteinHistone-lysine N-methyltransferase set-1Si:dkeyp-41f9.4PR domain containing 11PR domain containing 1cUncharacterized proteinUncharacterized proteinMyeloid/lymphoid or mixed-lineage leukemiaPR/SET domain 8PR domain 4Si:dkeyp-41f9.4Uncharacterized proteinUncharacterized proteinUncharacterized proteinHistone-lysine N-methyltransferaseUncharacterized proteinHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseUncharacterized proteinHistone-lysine N-methyltransferasePredicted proteinUncharacterized proteinHistone-lysine N-methyltransferaseUncharacterized proteinHistone-binding proteinSET domain-containing protein 3Uncharacterized proteinHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseUncharacterized proteinUncharacterized proteinPredicted proteinWhsc1 proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinHistone-lysine N-methyltransferaseHistone-lysine N-methyltransferaseSET and MYND domain-containing protein DDB_G0288495Uncharacterized proteinSET domain-containing proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinAGAP003597-PAUncharacterized proteinPredicted proteinHistone-lysine N-methyltransferaseUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinHistone-lysine N-methyltransferaseSET domain-containing protein 5Histone-lysine N-methyltransferaseUncharacterized proteinUncharacterized proteinSET and MYND domain containing, arthropod-specific, member 4, isoform CBAH domaincontaining proteinUncharacterized proteinPR/SET domain 12Uncharacterized proteinPR domain containing 4Uncharacterized proteinUncharacterized proteinNuclear receptor-binding SET domain protein 1SET and MYND domain containing 1bSET and MYND domain-containing protein DDB_G0288495SET and MYND domain containing 1aHistone-lysine N-methyltransferaseEukaryotic translation initiation factor 2 subunit 3-like Protein
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FunFam 17: Histone-lysine N-methyltransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
4 O88974 (/ISS) Q08BR4 (/ISS) Q1L8U8 (/ISS) Q6INA9 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 O88974 (/IPI) Q15047 (/IPI) Q96T68 (/IPI)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
3 O88974 (/IDA) Q15047 (/IDA) Q96T68 (/IDA)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
3 A4IGY9 (/ISS) Q6YI93 (/ISS) Q8C267 (/ISS)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
2 O88974 (/IDA) Q15047 (/IDA)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
2 O88974 (/ISO) Q8C267 (/ISO)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
2 O88974 (/IDA) Q15047 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 O88974 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q15047 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 O88974 (/ISO)
Showing 1 to 10 of 12 entries

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Positive regulation of methylation-dependent chromatin silencing GO:0090309
Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin.
5 O88974 (/ISS) Q08BR4 (/ISS) Q15047 (/ISS) Q1L8U8 (/ISS) Q6INA9 (/ISS)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
4 A4IGY9 (/ISS) Q6YI93 (/ISS) Q8C267 (/ISS) Q96T68 (/ISS)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
4 O88974 (/ISS) Q08BR4 (/ISS) Q1L8U8 (/ISS) Q6INA9 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
4 A4IGY9 (/ISS) Q6YI93 (/ISS) Q8C267 (/ISS) Q96T68 (/ISS)
Left/right axis specification GO:0070986
The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes).
4 A4IGY9 (/ISS) Q6YI93 (/ISS) Q8C267 (/ISS) Q96T68 (/ISS)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
3 A4IGY9 (/ISS) Q6YI93 (/ISS) Q8C267 (/ISS)
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
3 A4IGY9 (/ISS) Q6YI93 (/ISS) Q8C267 (/ISS)
Histone H3-K9 methylation GO:0051567
The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone.
3 A4IGY9 (/ISS) Q6YI93 (/ISS) Q8C267 (/ISS)
Response to vitamin GO:0033273
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.
2 A0A0G2K5A7 (/IEP) D4A081 (/IEP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
2 A0A0G2K5A7 (/IEP) D4A081 (/IEP)
Showing 1 to 10 of 26 entries

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O88974 (/IDA) Q15047 (/IDA) Q96T68 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 A4IGY9 (/ISS) Q6YI93 (/ISS) Q8C267 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 A0A087WYZ9 (/IDA) Q15047 (/IDA) Q96T68 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 A0A087WYZ9 (/IDA) Q15047 (/IDA) Q96T68 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O88974 (/ISO) Q8C267 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 O88974 (/ISO) Q8C267 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q15047 (/TAS) Q96T68 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O88974 (/ISO) Q8C267 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q15047 (/IMP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q15047 (/IMP)
Showing 1 to 10 of 16 entries
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