The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

Any process that modulates the frequency, rate or extent of chromatin organization.

The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.

The control of viability and duration in the adult phase of the life-cycle.

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.

The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone.

Any process that modulates the frequency, rate or extent of erythrocyte differentiation.

Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.

Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable.

The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.

The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.

Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing.

The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.

The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.

Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation.

Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation.

Any process that modulates the frequency, rate or extent of chromatin organization.

Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.

Any process that activates or increases the frequency, rate or extent of stem cell proliferation.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

That part of the nuclear content other than the chromosomes or the nucleolus.

That part of the nuclear content other than the chromosomes or the nucleolus.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.

A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

A dispersed and relatively uncompacted form of chromatin.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.

The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.

A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.

A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.

A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.

The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.

A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.