The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"DNA Topoisomerase I, domain 2
".
FunFam 1: DNA topoisomerase I
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 37 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
|
21 |
P79994 (/ISS)
Q07050 (/ISS)
Q54RC3 (/ISS)
Q7YR26 (/ISS)
Q7YR26 (/ISS)
Q8I3Z9 (/ISS)
Q8I3Z9 (/ISS)
Q8I3Z9 (/ISS)
Q8I3Z9 (/ISS)
Q8I3Z9 (/ISS)
(11 more) |
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
|
18 |
O17966 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P07799 (/IDA)
P11387 (/IDA)
P11387 (/IDA)
(8 more) |
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
|
13 |
A0A1D8PPI2 (/IMP)
P04786 (/IMP)
P04786 (/IMP)
P04786 (/IMP)
P04786 (/IMP)
P04786 (/IMP)
P04786 (/IMP)
P07799 (/IMP)
P11387 (/IMP)
P11387 (/IMP)
(3 more) |
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
6 | P41512 (/ISS) Q04750 (/ISS) Q07050 (/ISS) Q7YR26 (/ISS) Q7YR26 (/ISS) Q9WUL0 (/ISS) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
6 | P07799 (/IDA) P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) Q9WUL0 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | F4K3F4 (/IPI) P11387 (/IPI) P11387 (/IPI) P11387 (/IPI) P11387 (/IPI) |
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
4 | P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | P79994 (/ISS) Q07050 (/ISS) Q7YR26 (/ISS) Q7YR26 (/ISS) |
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
4 | P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) |
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
4 | P79994 (/ISS) Q07050 (/ISS) Q7YR26 (/ISS) Q7YR26 (/ISS) |
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
4 | P11387 (/HDA) P11387 (/HDA) P11387 (/HDA) P11387 (/HDA) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
4 | P11387 (/IPI) P11387 (/IPI) P11387 (/IPI) P11387 (/IPI) |
Supercoiled DNA binding GO:0097100
Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA.
|
4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
|
2 | A0A1D8PPI2 (/IGI) F4K3F4 (/IGI) |
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q04750 (/ISO) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q04750 (/ISO) |
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | Q04750 (/ISO) |
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
1 | P79994 (/IDA) |
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
1 | Q04750 (/ISO) |
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
1 | Q04750 (/ISO) |
DNA topoisomerase activity GO:0003916
Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
|
1 | P30189 (/IDA) |
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
|
1 | Q4Q2K0 (/EXP) |
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
|
1 | Q04750 (/ISO) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
1 | Q04750 (/ISO) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q04750 (/ISO) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | Q04750 (/ISO) |
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
1 | Q9WUL0 (/IDA) |
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
1 | Q04750 (/ISO) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q9WUL0 (/IDA) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q04750 (/ISO) |
DNA end binding GO:0045027
Interacting selectively and non-covalently with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs).
|
1 | P79994 (/IDA) |
Supercoiled DNA binding GO:0097100
Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA.
|
1 | Q04750 (/ISO) |
There are 64 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
21 |
F4K3F4 (/ISS)
P79994 (/ISS)
Q07050 (/ISS)
Q54RC3 (/ISS)
Q7YR26 (/ISS)
Q7YR26 (/ISS)
Q8I3Z9 (/ISS)
Q8I3Z9 (/ISS)
Q8I3Z9 (/ISS)
Q8I3Z9 (/ISS)
(11 more) |
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
16 |
P04786 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P11387 (/IDA)
P11387 (/IDA)
P11387 (/IDA)
P11387 (/IDA)
(6 more) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
15 |
Q8I3Z9 (/IDA)
Q8I3Z9 (/IDA)
Q8I3Z9 (/IDA)
Q8I3Z9 (/IDA)
Q8I3Z9 (/IDA)
Q8I3Z9 (/IDA)
Q8I3Z9 (/IDA)
Q8I3Z9 (/IDA)
Q8I3Z9 (/IDA)
Q8I3Z9 (/IDA)
(5 more) |
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
12 |
P04786 (/IMP)
P04786 (/IMP)
P04786 (/IMP)
P04786 (/IMP)
P04786 (/IMP)
P04786 (/IMP)
P07799 (/IMP)
P11387 (/IMP)
P11387 (/IMP)
P11387 (/IMP)
(2 more) |
Regulation of mitotic recombination GO:0000019
Any process that modulates the frequency, rate or extent of DNA recombination during mitosis.
|
6 | P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) |
Chromatin silencing at rDNA GO:0000183
Repression of transcription of ribosomal DNA by altering the structure of chromatin.
|
6 | P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) |
DNA strand elongation involved in DNA replication GO:0006271
The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication.
|
6 | P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) |
Chromatin assembly or disassembly GO:0006333
The formation or destruction of chromatin structures.
|
6 | P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) |
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
6 | P41512 (/ISS) Q04750 (/ISS) Q07050 (/ISS) Q7YR26 (/ISS) Q7YR26 (/ISS) Q9WUL0 (/ISS) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
6 | P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) |
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
|
6 | P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) |
Mitotic chromosome condensation GO:0007076
The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
|
6 | P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) |
Nuclear migration GO:0007097
The directed movement of the nucleus to a specific location within a cell.
|
6 | P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) P04786 (/IMP) |
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
6 | P41512 (/ISS) Q04750 (/ISS) Q07050 (/ISS) Q7YR26 (/ISS) Q7YR26 (/ISS) Q9WUL0 (/ISS) |
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
4 | P11387 (/IEP) P11387 (/IEP) P11387 (/IEP) P11387 (/IEP) |
Programmed cell death GO:0012501
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
|
4 | P11387 (/NAS) P11387 (/NAS) P11387 (/NAS) P11387 (/NAS) |
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
4 | P11387 (/NAS) P11387 (/NAS) P11387 (/NAS) P11387 (/NAS) |
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
4 | P11387 (/IEP) P11387 (/IEP) P11387 (/IEP) P11387 (/IEP) |
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
2 | P79994 (/ISS) Q54RC3 (/ISS) |
Instar larval development GO:0002168
The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster.
|
1 | P30189 (/IMP) |
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
1 | Q04750 (/IMP) |
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
1 | Q4Q2K0 (/EXP) |
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
1 | Q9FJ79 (/IC) |
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
1 | Q04750 (/ISO) |
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
1 | P79994 (/TAS) |
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
|
1 | P07799 (/IGI) |
Chromatin assembly or disassembly GO:0006333
The formation or destruction of chromatin structures.
|
1 | P07799 (/ISO) |
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | F4K3F4 (/IGI) |
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | Q04750 (/ISO) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q4Q2K0 (/EXP) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q581U8 (/IMP) |
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
1 | P79994 (/IMP) |
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
1 | P30189 (/IMP) |
Mitotic chromosome condensation GO:0007076
The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
|
1 | P07799 (/ISO) |
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
1 | P30189 (/IMP) |
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
1 | P30189 (/IMP) |
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
|
1 | Q9WUL0 (/IEP) |
RRNA transcription GO:0009303
The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.
|
1 | Q9WUL0 (/IMP) |
RRNA transcription GO:0009303
The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.
|
1 | Q04750 (/ISO) |
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
1 | A0A1D8PPI2 (/IMP) |
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
|
1 | F4K3F4 (/IMP) |
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
|
1 | F4K3F4 (/IMP) |
Meristem structural organization GO:0009933
Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue.
|
1 | F4K3F4 (/IMP) |
Leaf morphogenesis GO:0009965
The process in which the anatomical structures of the leaf are generated and organized.
|
1 | F4K3F4 (/IMP) |
Shoot system morphogenesis GO:0010016
The process in which the anatomical structures of the shoot are generated and organized. The shoot is the part of a seed plant body that is usually above ground.
|
1 | F4K3F4 (/IMP) |
Regulation of meristem growth GO:0010075
Any process involved in maintaining the size and shape of a meristem.
|
1 | F4K3F4 (/IMP) |
Response to gamma radiation GO:0010332
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
|
1 | Q9WUL0 (/IEP) |
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
1 | Q04750 (/ISO) |
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
|
1 | F4K3F4 (/IGI) |
Chromosome condensation GO:0030261
The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
|
1 | P30189 (/IMP) |
Hyphal growth GO:0030448
Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.
|
1 | A0A1D8PPI2 (/IMP) |
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
|
1 | Q9WUL0 (/IEP) |
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
1 | Q04750 (/ISO) |
Embryonic cleavage GO:0040016
The first few specialized divisions of an activated animal egg.
|
1 | Q04750 (/IMP) |
Embryonic cleavage GO:0040016
The first few specialized divisions of an activated animal egg.
|
1 | P79994 (/ISS) |
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
|
1 | P30189 (/IMP) |
Flower morphogenesis GO:0048439
The process in which the anatomical structures of the flower are generated and organized.
|
1 | F4K3F4 (/IMP) |
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
|
1 | P30189 (/IMP) |
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
|
1 | Q9WUL0 (/IEP) |
Cellular response to luteinizing hormone stimulus GO:0071373
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus.
|
1 | Q9WUL0 (/IEP) |
Plant organ formation GO:1905393
The process that gives rise to the plant organ. This process pertains to the initial formation of a structure from unspecified parts.
|
1 | F4K3F4 (/IMP) |
There are 48 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
22 |
E5KMK7 (/IDA)
E5KMK7 (/IDA)
O17966 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P04786 (/IDA)
P07799 (/IDA)
(12 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
15 |
Q8I3Z9 (/RCA)
Q8I3Z9 (/RCA)
Q8I3Z9 (/RCA)
Q8I3Z9 (/RCA)
Q8I3Z9 (/RCA)
Q8I3Z9 (/RCA)
Q8I3Z9 (/RCA)
Q8I3Z9 (/RCA)
Q8I3Z9 (/RCA)
Q8I3Z9 (/RCA)
(5 more) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
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7 | O17966 (/IDA) P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) P30189 (/IDA) Q581U8 (/IDA) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
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6 | P04786 (/IPI) P04786 (/IPI) P04786 (/IPI) P04786 (/IPI) P04786 (/IPI) P04786 (/IPI) |
Replication fork protection complex GO:0031298
A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.
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6 | P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) P04786 (/IDA) |
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
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5 | P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) Q9WUL0 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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5 | P07799 (/HDA) P11387 (/HDA) P11387 (/HDA) P11387 (/HDA) P11387 (/HDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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5 | P79994 (/ISS) Q07050 (/ISS) Q54RC3 (/ISS) Q7YR26 (/ISS) Q7YR26 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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5 | P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) Q581U8 (/IDA) |
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
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4 | P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) P11387 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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4 | P79994 (/ISS) Q07050 (/ISS) Q7YR26 (/ISS) Q7YR26 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | P11387 (/TAS) P11387 (/TAS) P11387 (/TAS) P11387 (/TAS) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
4 | P79994 (/ISS) Q07050 (/ISS) Q7YR26 (/ISS) Q7YR26 (/ISS) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
4 | E5KMK7 (/IDA) E5KMK7 (/IDA) Q969P6 (/IDA) Q969P6 (/IDA) |
DNA topoisomerase complex (ATP-hydrolyzing) GO:0009330
Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity.
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4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
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4 | P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) P11387 (/IMP) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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2 | Q04750 (/ISO) Q8R4U6 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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2 | Q04750 (/ISO) Q4Q2K0 (/ISO) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
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2 | Q04750 (/ISO) Q4Q2K0 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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2 | P30189 (/IDA) Q04750 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
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2 | Q581U8 (/IDA) Q9FJ79 (/IDA) |
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
|
2 | Q969P6 (/IDA) Q969P6 (/IDA) |
Nucleosome GO:0000786
A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
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1 | P79994 (/IDA) |
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
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1 | P07799 (/NAS) |
Condensed chromosome GO:0000793
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
|
1 | P79994 (/IDA) |
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
1 | Q04750 (/ISO) |
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
|
1 | Q04750 (/ISO) |
Dense fibrillar component GO:0001651
A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.
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1 | Q9WUL0 (/IDA) |
Dense fibrillar component GO:0001651
A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.
|
1 | Q04750 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q4Q2K0 (/EXP) |
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
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1 | P30189 (/IDA) |
Polytene chromosome puff GO:0005703
A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription.
|
1 | P30189 (/IDA) |
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
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1 | P30189 (/IDA) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | P07799 (/HDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P79994 (/ISS) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q8R4U6 (/HDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q8R4U6 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P30189 (/HDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P07799 (/IDA) |
DNA topoisomerase complex (ATP-hydrolyzing) GO:0009330
Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity.
|
1 | Q04750 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q4Q2K0 (/ISO) |
Spindle pole centrosome GO:0031616
A centrosome from which one pole of a mitotic or meiotic spindle is organized.
|
1 | O17966 (/IDA) |
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
1 | Q04750 (/ISO) |
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
|
1 | Q8R4U6 (/ISO) |
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
|
1 | Q04750 (/IDA) |
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
|
1 | P79994 (/ISS) |