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CATH Superfamily 2.140.10.30

Dipeptidylpeptidase IV, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Dipeptidylpeptidase IV, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Dipeptidylpeptidase IV, N-terminal domain

Structural domains comprising this superfamily share the structure of the N-terminal beta propeller domain of dipeptidylpeptidase IV, a multifunctional type II transmembrane serine peptidase. This enzyme contributes to the regulation of various physiological processes, including blood sugar homeostasis, by cleaving peptide hormones, chemokines and neuropeptides after a proline or alanine at amino acid position 2 from the N terminus PMID:14718659. Dipeptidylpetidase IV also serves as the costimulatory molecule in T cell activation and is an associated marker of autoimmune diseases, adenosine deaminase-deficiency and HIV pathogenesis PMID:1352530,PMID:20959412,PMID:21856036.

GO Diversity

Unique GO annotations
86 Unique GO terms

EC Diversity

Unique EC annotations
3 Unique EC terms

Species Diversity

Unique species annotations
4626 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 329
Domain clusters (>95% seq id): 9
Domain clusters (>35% seq id): 5
Unique PDBs: 134
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 17
Function
Unique EC: 3
Unique GO: 86
Taxonomy
Unique Species: 4626
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