The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Tumor Necrosis Factor Receptor, subunit A, domain 2
".
FunFam 36: Tumor necrosis factor receptor superfamily member ...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P20333 (/IPI) P25119 (/IPI) P25119 (/IPI) |
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
|
2 | P25119 (/IPI) P25119 (/IPI) |
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
|
2 | P25119 (/ISO) P25119 (/ISO) |
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
2 | P25119 (/ISO) P25119 (/ISO) |
Tumor necrosis factor binding GO:0043120
Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.
|
2 | P25119 (/ISO) P25119 (/ISO) |
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
|
1 | Q80WY6 (/IDA) |
Tumor necrosis factor-activated receptor activity GO:0005031
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
|
1 | P20333 (/TAS) |
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | P20333 (/IPI) |
Tumor necrosis factor binding GO:0043120
Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.
|
1 | P20333 (/IPI) |
Showing 1 to 9 of 9 entries
There are 56 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Regulation of T cell cytokine production GO:0002724
Any process that modulates the frequency, rate, or extent of T cell cytokine production.
|
2 | P25119 (/IMP) P25119 (/IMP) |
Regulation of cytokine secretion involved in immune response GO:0002739
Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response.
|
2 | P25119 (/IGI) P25119 (/IGI) |
Aortic valve development GO:0003176
The progression of the aortic valve over time, from its formation to the mature structure.
|
2 | P25119 (/IGI) P25119 (/IGI) |
Pulmonary valve development GO:0003177
The progression of the pulmonary valve over time, from its formation to the mature structure.
|
2 | P25119 (/IGI) P25119 (/IGI) |
Negative regulation of extracellular matrix constituent secretion GO:0003332
Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
|
2 | P25119 (/IGI) P25119 (/IGI) |
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
2 | P25119 (/IMP) P25119 (/IMP) |
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
2 | P25119 (/ISO) P25119 (/ISO) |
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
2 | P25119 (/IMP) P25119 (/IMP) |
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
2 | P25119 (/IMP) P25119 (/IMP) |
Negative regulation of cardiac muscle hypertrophy GO:0010614
Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
|
2 | P25119 (/IGI) P25119 (/IGI) |
Showing 1 to 10 of 56 entries
There are 18 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
3 | P25119 (/IDA) P25119 (/IDA) Q80WY6 (/IDA) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
3 | P20333 (/IDA) P25119 (/IDA) P25119 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P25119 (/ISO) P25119 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | P25119 (/ISO) P25119 (/ISO) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
2 | P25119 (/ISO) P25119 (/ISO) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | P25119 (/ISO) P25119 (/ISO) |
Varicosity GO:0043196
Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.
|
2 | P25119 (/ISO) P25119 (/ISO) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
2 | P25119 (/ISO) P25119 (/ISO) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
2 | P25119 (/ISO) P25119 (/ISO) |
Tumor necrosis factor receptor superfamily complex GO:0002947
A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily.
|
1 | P20333 (/TAS) |
Showing 1 to 10 of 18 entries